Ashley E Fenwick

US Patent:

20120309776, Dec 6, 2012

Filed:

Jan 24, 2011

Appl. No.:

13/576685

Inventors:

Ashley Fenwick - Richland MI, US
Timothy Allen Johnson - Richland MI, US
Graham M. Kyne - Portage MI, US

International Classification:

A61K 31/519
A61P 37/08
A61P 17/00
A61P 19/02
A61P 25/00
A61P 29/00
A61P 11/00
A61P 27/02
C07D 487/04
A61P 17/04

US Classification:

5142651, 544280

Abstract:

The present invention provides pyrrolo{2,3-d}pyrimidine compounds, their use as Janus Kinase (JAK) inhibitors, pharmaceutical compositions containing this compounds, and methods for the preparation of these compounds.

US Patent:

57338825, Mar 31, 1998

Filed:

Feb 28, 1995

Appl. No.:

8/396356

Inventors:

Thomas Joseph Carr - Phoenixville PA
Peter Lawrence DeMarsh - Downingtown PA
Geoffrey Bainbridge Dreyer - Malvern PA
Ashley Edward Fenwick - Radnor PA

Assignee:

SmithKline Beecham Corporation - Philadelphia PA

International Classification:

C07D23364
A61K 31415

US Classification:

514 19

Abstract:

The present invention provides compounds, more particularly dipeptide analogs, which bind to retroviral proteases. These compounds are inhibitors of retroviral proteases and are useful for treating diseases related to infection by retroviruses.

US Patent:

20230071039, Mar 9, 2023

Filed:

Jul 22, 2022

Appl. No.:

17/870885

Inventors:

- Parsippany NJ, US
Ashley E. Fenwick - Naperville IL, US
Govindan Subramanian - Belle Mead NJ, US

International Classification:

C07D 451/04
C07D 519/00

Abstract:

The invention describes novel serotonin c5-HT2B receptor antagonists of Formula (1), and pharmaceutically acceptable salts thereof; wherein Ring A, L, X, X′,R, R, m and n are as defined herein. Also described are compositions comprising a Formula (1) compound, or a pharmaceutically acceptable salt thereof; and methods of using the compounds, or a pharmaceutically acceptable salt thereof, for the treatment of myxomatous mitral valve disease (MMVD), congestive heart failure (CHF) and/or asymptomatic heart failure in animals, preferably is a canine.

US Patent:

20150246048, Sep 3, 2015

Filed:

May 18, 2015

Appl. No.:

14/715046

Inventors:

- New York NY, US
Ashley Edward Fenwick - Richland MI, US
Mark Edward Flanagan - Gales Ferry CT, US
Andrea Gonzales - Kalamazoo MI, US
Timothy Allan Johnson - Vicksburg MI, US
Neelu Kaila - Lexington MA, US
Mark J. Mitton-Fry - Granville OH, US
Joseph Walter Strohbach - Wentzville MO, US
Ruth E. TenBrink - Labadie MO, US
John David Trzupek - Medford MA, US
Rayomand Jal Unwalla - Bedford MA, US
Michael L. Vazquez - Billerica MA, US
Mihir D. Parikh - Groton CT, US

International Classification:

A61K 31/519
A61K 31/5386

Abstract:

Described herein are pyrrolo{2,3-d}pyrimidine derivatives, their use as Janus Kinase (JAK) inhibitors, and pharmaceutical compositions containing them.

US Patent:

20150225408, Aug 13, 2015

Filed:

Apr 21, 2015

Appl. No.:

14/691606

Inventors:

- New York NY, US
Ashley Edward Fenwick - Richland MI, US
Mark Edward Flanagan - Gales Ferry CT, US
Andrea Gonzales - Kalamazoo MI, US
Timothy Allan Johnson - Vicksburg MI, US
Neelu Kaila - Lexington MA, US
Mark J. Mitton-Fry - Granville OH, US
Joseph Walter Strohbach - Wentzville MO, US
Ruth E. TenBrink - Labadie MO, US
John David Trzupek - Medford MA, US
Rayomand Jal Unwalla - Bedford MA, US
Michael L. Vazquez - Billerica MA, US
Mihir D. Parikh - Groton CT, US

International Classification:

C07D 487/04
C07D 519/00

Abstract:

Described herein are pyrrolo{2,3-d}pyrimidine derivatives, their use as Janus Kinase (JAK) inhibitors, and pharmaceutical compositions containing them.

US Patent:

20140243312, Aug 28, 2014

Filed:

Feb 19, 2014

Appl. No.:

14/183946

Inventors:

- New York NY, US
Ashley Edward Fenwick - Richland MI, US
Mark Edward Flanagan - Gales Ferry CT, US
Andrea Gonzales - Kalamazoo MI, US
Timothy Allan Johnson - Vicksburg MI, US
Neelu Kaila - Lexington MA, US
Mark J. Mitton-Fry - Granville OH, US
Joseph Walter Strohbach - Wentzville MO, US
Ruth E. TenBrink - Labadie MO, US
John David Trzupek - Medford MA, US
Rayomand Jal Unwalla - Bedford MA, US
Michael L. Vazquez - Billerica MA, US

Assignee:

Pfizer Inc. - New York NY

International Classification:

C07D 487/04

US Classification:

51421021, 544280, 5142651

Abstract:

Described herein are pyrrolo{2,3-d}pyrimidine derivatives, their use as Janus Kinase (JAK) inhibitors, and pharmaceutical compositions containing them.