Atul K Verma

Author:

Atul Kumar Verma

ISBN #:

8185205442

US Patent:

7405235, Jul 29, 2008

Filed:

Nov 3, 2003

Appl. No.:

10/700661

Inventors:

Stuart B. Levy - Boston MA, US
Michael N. Alekshun - Wakefield MA, US
Brent L. Podlogar - Flemington NJ, US
Kwasi Ohemeng - Norwood MA, US
Atul K. Verma - Mansfield MA, US
Tadeusz Warchol - Northborough MA, US
Beena Bhatia - Mansfield MA, US
Todd Bowser - Charlton MA, US
Mark Grier - Cambridge MA, US

Assignee:

Paratek Pharmaceuticals, Inc. - Boston MA

International Classification:

A61K 31/415
C07D 235/00

US Classification:

514394, 5483044

Abstract:

Substituted benzoimidazole compounds useful as anti-infectives that decrease resistance, virulence, or growth of microbes are provided. Methods of making and using substituted benzoimidazole compounds, as well as pharmaceutical preparations thereof, in, e. g. , reducing antibiotic resistance and inhibiting biofilms.

US Patent:

7595309, Sep 29, 2009

Filed:

May 24, 2004

Appl. No.:

10/853635

Inventors:

Mark L. Nelson - Norfolk MA, US
Roger Frechette - Reading MA, US
Peter Viski - Brookline MA, US
Beena Bhatia - Mansfield MA, US
David Messersmith - Somerville MA, US
Mohamed Y. Ismail - Bedford MA, US
Todd Bowser - Charlton MA, US
Laura McIntyre - Arlington MA, US
Darrell J. Koza - Westerly RI, US
Glen Rennie - Somerville MA, US
Paul Sheahan - San Diego CA, US
Paul Hawkins - Cambridge MA, US
Atul K. Verma - Mansfield MA, US
Tadeusz Warchol - Northborough MA, US
Upul Bandarage - Lexington MA, US

Assignee:

Trustees of Tufts College - Medford MA
Paratek Pharmaceuticals, Inc. - Boston MA

International Classification:

A61K 31/65
C07C 43/00
C07D 221/18

US Classification:

514152, 546 61, 546339, 549 25, 552203

Abstract:

The present invention pertains, at least in part, to novel 7-substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.

US Patent:

8048867, Nov 1, 2011

Filed:

May 4, 2004

Appl. No.:

10/839023

Inventors:

Mark L. Nelson - Norfolk MA, US
Roger Frechette - Reading MA, US
Peter Viski - Brookline MA, US
Mohamed Y. Ismail - Bedford MA, US
Todd Bowser - Charlton MA, US
Jimmy Dumornay - Walpole MA, US
Glen Rennie - Somerville MA, US
Gui Liu - Medford MA, US
Darrell J. Koza - Westerly RI, US
Paul Sheahan - San Diego CA, US
Karen Stapleton - Weymouth MA, US
Paul Hawkins - Cambridge MA, US
Beena Bhatia - Mansfield MA, US
Atul K. Verma - Mansfield MA, US
Laura McIntyre - Arlington MA, US
Tadeusz Warchol - Northborough MA, US
David Messersmith - Somerville MA, US

Assignee:

Trustees of Tufts College - Medford MA
Paratek Pharmaceuticals, Inc. - Boston MA

International Classification:

A61K 31/59
C07C 401/00

US Classification:

514152, 552203

Abstract:

The present invention pertains, at least in part, to novel 9-substituted minocycline compounds. These minocycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.

US Patent:

8492365, Jul 23, 2013

Filed:

Jun 9, 2009

Appl. No.:

12/481368

Inventors:

Mark L. Nelson - Wellesley MA, US
Roger Frechette - Reading MA, US
Peter Viski - Brookline MA, US
Mohamed Ismail - Bedford MA, US
Todd Bowser - Charlton MA, US
Beena Bhatia - Arlington MA, US
David Messersmith - Somerville MA, US
Laura McIntyre - Arlington MA, US
Darrell Koza - Westerly RI, US
Glen Rennie - South Weymouth MA, US
Paul Sheahan - Hopkinton MA, US
Paul Hawkins - Cambridge MA, US
Atul Verma - Arlington MA, US
Tadeusz Warchol - Acton MA, US
Upul Bandarage - Newton MA, US

Assignee:

Trustees of Tufts College - Boston MA
Paratek Pharmaceuticals, Inc. - Boston MA

International Classification:

A61K 31/65
A61K 31/42
A61K 31/426
A61K 31/4402
A61K 31/505
A61K 31/5375
C07C 237/26
C07D 239/26
C07D 295/104
C07D 261/08
C07D 277/42

US Classification:

514152, 514256, 514357, 5142375, 514379, 514370, 544294, 544154, 548248, 548193, 552202, 552203, 546285

Abstract:

The present invention pertains, at least in part, to novel 7-substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.

US Patent:

20030055025, Mar 20, 2003

Filed:

Jun 29, 2001

Appl. No.:

09/895812

Inventors:

Mark Nelson - Wellesley MA, US
Roger Frechette - Reading MA, US
Peter Viski - Brookline MA, US
Mohamed Ismail - Bedrford MA, US
Todd Bowser - Charlton MA, US
Beena Bhatia - Arlington MA, US
David Messersmith - Somerville MA, US
Laura McIntyre - Arlington MA, US
Darrell Koza - Westerly RI, US
Glen Rennie - Weymouth MA, US
Paul Sheahan - Hopkinton MA, US
Paul Hawkins - Cambridge MA, US
Atul Verma - Arlington MA, US
Tadeusz Warchol - Acton MA, US
Upul Bandarage - Newton MA, US

International Classification:

A61K031/65
C07D335/04
C07D311/02
C07D221/22

US Classification:

514/152000, 514/284000, 514/431000, 514/453000, 546/061000, 549/024000, 549/384000, 552/203000

Abstract:

The present invention pertains, at least in part, to novel 7-substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.

US Patent:

20030125348, Jul 3, 2003

Filed:

Jun 29, 2001

Appl. No.:

09/895857

Inventors:

Mark Nelson - Wellesley MA, US
Roger Frechette - Reading MA, US
Peter Viski - Brookline MA, US
Mohamed Ismail - Bedford MA, US
Todd Bowser - Charlton MA, US
Jimmy Dumornay - Walpole MA, US
Glen Rennie - South Weymouth MA, US
Gui Liu - Medford MA, US
Darrell Koza - Westerly RI, US
Paul Sheahan - San Diego CA, US
Karen Stapleton - Weymouth MA, US
Paul Hawkins - Cambridge MA, US
Beena Bhatia - Arlington MA, US
Atul Verma - Arlington MA, US
Laura McIntyre - Arlington MA, US
Tadeusz Warchol - Acton MA, US
David Messersmith - Somerville MA, US

International Classification:

A61K031/44
C07C050/22
C07C050/36

US Classification:

514/284000, 552/200000

Abstract:

The present invention pertains, at least in part, to novel 9-substituted minocycline compounds. These minocycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.

US Patent:

20030229065, Dec 11, 2003

Filed:

Aug 14, 2002

Appl. No.:

10/139591

Inventors:

Stuart Levy - Boston MA, US
Michael Alekshun - Wakefield MA, US
Brent Podlogar - Hamden CT, US
Kwasi Ohemeng - Norwood MA, US
Atul Verma - Arlington MA, US
Tadeusz Warchol - Norborough MA, US
Beena Bhatia - Arlington MA, US

International Classification:

A61K031/555
A61K031/505
A61K031/4745
A61K031/47
A61K031/415
A61K031/40
A61K031/407

US Classification:

514/185000, 514/256000, 514/311000, 514/303000, 514/383000, 514/381000, 514/394000, 514/410000, 514/408000

Abstract:

Methods for identifying compound useful as anti-infectives that decrease resistance, virulence, or growth of microbes are provided. In one embodiment, the method comprises contacting a microbial cell comprising: 1) a selectable marker under the control of a transcription factor responsive element and 2) a transcription factor, with a compound under conditions which allow interaction of the compound with the microbial cell; and measuring the ability of the compound to affect the growth or survival of the microbial cell as an indication of whether the test compound modulates the activity of a transcription factor.

US Patent:

20050026875, Feb 3, 2005

Filed:

Dec 15, 2003

Appl. No.:

10/737361

Inventors:

Mark Nelson - Norfolk MA, US
Kwasi Ohemeng - Norwood MA, US
Roger Frechette - Reading MA, US
Paul Abato - Providence RI, US
Victor Amoo - Daphne AL, US
Haregewein Assefa - Braintree MA, US
Joel Berniac - Stoneham MA, US
Beena Bhatia - Mansfield MA, US
Todd Bowser - Charlton MA, US
Jackson Chen - Brookline MA, US
Laura Honeyman - Roslindale MA, US
Mohamed Ismail - Bedford MA, US
Oak Kim - Cambridge MA, US
Rachid Mechiche - South Boston MA, US
N. Reddy - Solon OH, US
Atul Verma - Mansfield MA, US
Peter Viski - Asharoken NY, US
Tadeusz Warchol - Northborough MA, US
Ivan Yanachkov - Newton MA, US

Assignee:

Paratek Pharmaceuticals, Inc. - Boston MA

International Classification:

A61K031/65
C07D265/30
C07D211/06

US Classification:

514152000, 544154000, 544406000, 546195000, 546285000

Abstract:

Aminomethyl substituted tetracycline compounds, pharmaceutical compositions, and methods of use thereof are discussed.