Dennis C Tagliaferro

US Patent:

54648505, Nov 7, 1995

Filed:

May 17, 1994

Appl. No.:

8/245303

Inventors:

Liann Voo - West Roxbury MA
Dennis C. Tagliaferro - Tewksbury MA
Joan B. Wilson - Walpole MA

Assignee:

Ciba Corning Diagnostics Corp. - Medfield MA

International Classification:

A61K 31425

US Classification:

514372

Abstract:

A family of solutions that can be used to calibrate one or more electrochemical sensors has been developed. These systems can be used to determine analytes in biological fluids, such as whole blood, serum, plasma and urine. Since these reagents require preservatives in order to make their shelf life and use life commercially feasible, a system of preservatives which exhibits unexpected synergy in antimicrobial capabilities has been identified. The preferred preservative system includes a mixture of 5-chloro-2-methyl-4-isothiazolin-3-one; 2-methyl-4-isothiazolin-3-one; and 1,3-bis-(hydroxymethyl)-5,5-dimethyl-2,4-imidazolidinedione.