John P Pieracci

US Patent:

7220356, May 22, 2007

Filed:

Sep 12, 2003

Appl. No.:

10/661086

Inventors:

Jörg Thommes - San Diego CA, US
John P. Pieracci - San Diego CA, US
Marc Bisschops - Breda, NL
Alan M. Sonnenfeld - San Diego CA, US
Lynn Conley - Escondido CA, US
Marten Pennings - The Hague, NL

Assignee:

Biogen Idec Inc. - Cambridge MA

International Classification:

B01D 15/08

US Classification:

210635, 210659, 2101982, 530413

Abstract:

Provided are methods of separating an immunoreactive compound from at least one immaterial component, using a simulated moving bed (“SMB”) system and a SMB apparatus for use in these methods. Also provided are purified immunoreactive compounds prepared using the SMB methods and apparatus and methods of treatment with the purified immunoreactive compounds.

US Patent:

8608960, Dec 17, 2013

Filed:

May 21, 2007

Appl. No.:

11/751147

Inventors:

Jorg Thommes - San Diego CA, US
Alan M. Sonnenfeld - San Diego CA, US
John P. Pieracci - San Diego CA, US
Lynn Conley - Carlsbad CA, US
Marc Bisschops - Leiden, NL
Maarten Pennings - Lieden, NL

Assignee:

Biogen Idec Inc. - Weston MA

International Classification:

B01D 15/08

US Classification:

2101982, 210635, 210656, 210659

Abstract:

Provided are methods of separating an immunoreactive compound from at least one immaterial component, using a simulated moving bed (“SMB”) system and a SMB apparatus for use in these methods. Also provided are purified immunoreactive compounds prepared using the SMB methods and apparatus and methods of treatment with the purified immunoreactive compounds.

US Patent:

20130331554, Dec 12, 2013

Filed:

Nov 15, 2011

Appl. No.:

13/885446

Inventors:

Asif Ladiwala - San Diego CA, US
John Pieracci - Encinitas CA, US

Assignee:

BIOGEN IDEC INC. - Weston MA

International Classification:

C07K 1/22

US Classification:

5303873

Abstract:

Disclosed is a method for enhancing or increasing the concentration of biological product in a final mixture, wherein said biological product has one or more selected characteristics, wherein said method comprises: (a) allowing an initial mixture of biological products with and without said selected characteristics to contact a chromatography medium wherein the quantity of biological products in said initial mixture exceeds the binding capacity or the dynamic binding capacity of said chromatography medium; (b) allowing biological product not having said one or more selected characteristics to be separated by said chromatography medium; and (c) recovering a final mixture of biological products from said chromatography medium wherein said final mixture comprises an enhanced or increased concentration of biological product with one or more selected characteristics, compared to the concentration of biological product in said initial mixture.