Robert P Ragusa

US Patent:

6825047, Nov 30, 2004

Filed:

Jul 28, 2000

Appl. No.:

09/627580

Inventors:

Timothy W. Woudenberg - Moss Beach CA
Michael Albin - Antioch CA
Reid B. Kowallis - Burlingame CA
Yefim Raysberg - Fremont CA
Robert P. Ragusa - Los Altos CA
Emily S. Winn-Deen - Potomac MD

Assignee:

Applera Corporation - Foster City CA

International Classification:

G01N 33543

US Classification:

436518, 536 231, 436164, 436536, 436546, 435 6, 422 50, 422 55, 422 57, 422100

Abstract:

The invention is directed to a method and device for simultaneously testing a sample for the presence, absence, and/or amounts of one or more a plurality of selected analytes. The invention includes, in one aspect, a device for detecting or quantitating a plurality of different analytes in a liquid sample. The device includes a substrate which defines a sample-distribution network having (i) a sample inlet, (ii) one or more detection chambers, and (iii) channel means providing a dead-end fluid connection between each of the chambers and the inlet. Each chamber may include an analyte-specific reagent effective to react with a selected analyte that may be present in the sample, and detection means for detecting the signal. Also disclosed are methods utilizing the device.

US Patent:

7211443, May 1, 2007

Filed:

Feb 24, 2003

Appl. No.:

10/373450

Inventors:

Timothy M. Woudenberg - Moss Beach CA, US
Michael Albin - Antioch CA, US
Reid B. Kowalis - Burlingame CA, US
Yefim Raysberg - Fremont CA, US
Robert P. Ragusa - Redwood City CA, US
Emily S. Winn-Deen - Livermore CA, US

Assignee:

Applera Corporation - Foster City CA

International Classification:

G01N 33/543
G01N 15/06
G01N 33/53
G01N 33/533
G01N 33/542
G01N 33/566
G01N 21/00
C12Q 1/68
B32B 5/02
B32B 27/12
B01L 3/00
C12M 1/34

US Classification:

436518, 436164, 436501, 436536, 436546, 436807, 422 50, 422 55, 422 57, 422 58, 422 681, 422100, 422102, 422 8205, 422 8208, 422 61, 435 4, 435 6, 435 71, 4352871, 4352872, 4352876, 4352879, 4352884, 4352885, 4352887

Abstract:

The invention is directed to a method and device for simultaneously testing a sample for the presence, absence, and/or amounts of one or more a plurality of selected analytes. The invention includes, in one aspect, a device for detecting or quantitating a plurality of different analytes in a liquid sample. The device includes a substrate which defines a sample-distribution network having (i) a sample inlet, (ii) one or more detection chambers, and (iii) channel means providing a dead-end fluid connection between each of the chambers and the inlet. Each chamber may include an analyte-specific reagent effective to react with a selected analyte that may be present in the sample, and detection means for detecting the signal. Also disclosed are methods utilizing the device.

US Patent:

7235406, Jun 26, 2007

Filed:

Jul 28, 2000

Appl. No.:

09/628076

Inventors:

Timothy W. Woudenberg - Moss Beach CA, US
Michael Albin - Antioch CA, US
Reid B. Kowallis - Burlingame CA, US
Yefim Raysberg - Fremont CA, US
Robert P. Ragusa - Los Altos CA, US
Emily S. Winn-Deen - Potomac MD, US

Assignee:

Applera Corporation - Foster City CA

International Classification:

G01N 33/543
G01N 21/00
G01N 15/06
G01N 33/53
G01N 33/533
G01N 33/542
G01N 33/566
C12Q 1/68
C12M 1/34
B01L 3/00
B32B 5/02
B32B 27/12

US Classification:

436518, 436164, 436501, 436536, 436546, 436807, 422 50, 422 55, 422 57, 422 58, 422 681, 422100, 422102, 422 8205, 422 8208, 435 6, 435 71, 4352872, 4352884, 4352885, 4352887

Abstract:

The invention is directed to a method and device for simultaneously testing a sample for the presence, absence, and/or amounts of one or more a plurality of selected analytes. The invention includes, in one aspect, a device for detecting or quantitating a plurality of different analytes in a liquid sample. The device includes a substrate which defines a sample-distribution network having (i) a sample inlet, (ii) one or more detection chambers, and (iii) channel means providing a dead-end fluid connection between each of the chambers and the inlet. Each chamber may include an analyte-specific reagent effective to react with a selected analyte that may be present in the sample, and detection means for detecting the signal. Also disclosed are methods utilizing the device.

US Patent:

7244622, Jul 17, 2007

Filed:

Jan 5, 2005

Appl. No.:

11/029968

Inventors:

Timothy M. Woudenberg - Moss Beach CA, US
Michael Albin - Antioch CA, US
Reid B. Kowallis - Burlingame CA, US
Yefim Raysberg - Fremont CA, US
Robert P. Ragusa - Los Altos CA, US
Emily S. Winn-Deen - Foster City CA, US

Assignee:

Applera Corporation - Foster City CA

International Classification:

G01N 33/543
G01N 15/06
G01N 33/53
G01N 33/566
G01N 21/00
C12Q 1/68
B32B 5/02
B32B 27/12
B01L 3/00
C12M 1/34

US Classification:

436518, 422 50, 422 55, 422 57, 422 58, 422 681, 422102, 422 8205, 422 8208, 435 6, 435 71, 4352872, 4352884, 4352885, 4352887, 436164, 436501, 436807

Abstract:

The invention is directed to a method and device for simultaneously testing a sample for the presence, absence, and/or amounts of one or more of a plurality of selected analytes. The invention includes, in one aspect, a device for detecting or quantitating a plurality of different analytes in a liquid sample. Each chamber may include an analyte-specific reagent effective to react with a selected analyte that may be present in the sample, and detection means for detecting the signal. Also disclosed are methods utilizing the device.

US Patent:

7381570, Jun 3, 2008

Filed:

Feb 8, 2006

Appl. No.:

11/350320

Inventors:

Timothy M. Woudenberg - Moss Beach CA, US
Michael Albin - Antioch CA, US
Reid B. Kowallis - Burlingame CA, US
Yefim Raysberg - Fremont CA, US
Robert P. Ragusa - Los Altos CA, US
Emily S. Winn-Deen - Potomac MD, US

Assignee:

Applera Corporation - Foster City CA

International Classification:

G01N 33/543
G01N 15/06
G01N 33/53
G01N 33/566
G01N 21/00
C12M 1/34
C12Q 1/68
B32B 5/02
B32B 27/12
B01L 3/00

US Classification:

436518, 422 50, 422 55, 422 57, 422 58, 422 681, 422102, 422 8205, 422 8208, 435 6, 435 71, 4352872, 4352884, 4352885, 4352887, 436164, 436501, 436807

Abstract:

The invention is directed to a method and device for simultaneously testing a sample for the presence, absence, and/or amounts of one or more of a plurality of selected analytes. The invention includes, in one aspect, a device for detecting or quantitating a plurality of different analytes in a liquid sample. Each chamber may include an analyte-specific reagent effective to react with a selected analyte that may be present in the sample, and detection means for detecting the signal. Also disclosed are methods utilizing the device.

US Patent:

7381571, Jun 3, 2008

Filed:

Feb 24, 2006

Appl. No.:

11/362475

Inventors:

Timothy M. Woudenberg - Moss Beach CA, US
Michael Albin - Antioch CA, US
Reid B. Kowallis - Burlingame CA, US
Yefim Raysberg - Fremont CA, US
Robert P. Ragusa - Los Altos CA, US
Emily S. Winn-Deen - Potomac MD, US

Assignee:

Applera Corporation - Foster City CA

International Classification:

G01N 33/543
G01N 15/06
G01N 33/53
G01N 33/566
G01N 21/00
C12Q 1/68
B32B 5/02
B32B 27/12
B01L 3/00
C12M 1/34

US Classification:

436518, 422 50, 422 55, 422 57, 422 58, 422 681, 422102, 422 8205, 422 8208, 435 6, 435 71, 4352872, 4352884, 4352885, 4352887, 436164, 436501, 436807

Abstract:

The invention is directed to a method and device for simultaneously testing a sample for the presence, absence, and/or amounts of one or more of a plurality of selected analytes. The invention includes, in one aspect, a device for detecting or quantitating a plurality of different analytes in a liquid sample. Each chamber may include an analyte-specific reagent effective to react with a selected analyte that may be present in the sample, and detection means for detecting the signal. Also disclosed are methods utilizing the device.

US Patent:

7687280, Mar 30, 2010

Filed:

May 29, 2007

Appl. No.:

11/807536

Inventors:

Timothy Woudenberg - Moss Beach CA, US
Michael Albin - Antioch CA, US
Reid B. Kowallis - Burlingame CA, US
Yefim Raysberg - Fremont CA, US
Robert P. Ragusa - Los Altos CA, US
Emily S. Winn-Deen - Foster City CA, US

Assignee:

Applied Biosystems, LLC - Carlsbad CA

International Classification:

G01N 33/543
G01N 15/06
G01N 33/53
G01N 33/566
G01N 21/00
C12Q 1/68
B32B 5/02
B32B 27/12
B01L 3/00
C12M 1/34

US Classification:

436501, 422 50, 422 55, 422 57, 422 58, 422 681, 422102, 422 8205, 422 8208, 435 6, 435 71, 4352872, 4352884, 4352885, 4352887, 436518, 436164, 436807

Abstract:

The invention is directed to a method and device for simultaneously testing a sample for the presence, absence, and/or amounts of one or more of a plurality of selected analytes. The invention includes, in one aspect, a device for detecting or quantitating a plurality of different analytes in a liquid sample. Each chamber may include an analyte-specific reagent effective to react with a selected analyte that may be present in the sample, and detection means for detecting the signal. Also disclosed are methods utilizing the device.

US Patent:

7833711, Nov 16, 2010

Filed:

Apr 7, 2006

Appl. No.:

11/400611

Inventors:

Timothy M. Woudenberg - Moss Beach CA, US
Michael Albin - Antioch CA, US
Reid B. Kowallis - Burlingame CA, US
Yefim Raysberg - Fremont CA, US
Robert P. Ragusa - Los Altos CA, US
Emily S. Winn-Deen - Potomac MD, US

Assignee:

Applied Biosystems, LLC - Carlsbad CA

International Classification:

C12Q 1/68

US Classification:

435 6, 422 50, 422 58, 422 61, 422 681, 436164, 436172, 436518, 436805, 436807

Abstract:

The invention is directed to a method and device for simultaneously testing a sample for the presence, absence, and/or amounts of one or more of a plurality of selected analytes. The invention includes, in one aspect, a device for detecting or quantitating a plurality of different analytes in a liquid sample. Each chamber may include an analyte-specific reagent effective to react with a selected analyte that may be present in the sample, and detection means for detecting the signal. Also disclosed are methods utilizing the device.