Aby Mathew

US Patent:

8642255, Feb 4, 2014

Filed:

Mar 27, 2009

Appl. No.:

12/934644

Inventors:

Ian B. Nicoud - Seattle WA, US
Dominic M. Clarke - Bothell WA, US
Aby J. Mathew - Vestal NY, US
Michael Rice - Woodinville WA, US

Assignee:

Biolife Solutions, Inc. - Bothell WA

International Classification:

A01N 1/02

US Classification:

435 2

Abstract:

The present invention relates to materials and methods for hypothermic collection of whole blood, and components thereof, which can extend the holding time of blood beyond the current useable limit. Additionally, blood can be drawn directly into a hypothermic preservation solution without the addition of standard anticoagulants. This is enabled by providing sustained cellular viability under hypothermic conditions using a nutrient matrix devoid of animal proteins and containing energy substrates, free-radical scavengers, and impermeants that is ionically balanced for storage of biologic materials at low temperatures to prevent cellular stress-induced apoptosis.

US Patent:

20030232396, Dec 18, 2003

Filed:

Feb 21, 2003

Appl. No.:

10/372579

Inventors:

Aby Mathew - Binghamton NY, US
John Baust - Candor NY, US
Robert VanBuskirk - Apalachian NY, US

Assignee:

BioLife Solutions, Inc.

International Classification:

G01N033/53
G01N033/567
C12M001/34

US Classification:

435/007200, 435/287200

Abstract:

The present invention is directed to systems and methods for assessing the success of the transplant of a cell, tissue, or organ before and after transplant. Protein array technology is used to obtain a biomarker pattern for the cell, tissue, or organ that is being considered for transplant or that has been transplanted. Samples for the identification of biomarkers and biomarker patterns are obtained from the cell, tissue or organ itself, or from a body fluid of the donor or recipient. Sample biomarker data are compared to reference biomarker data obtained from donors, recipients or cells, tissues or organs that have been transplanted. Correlation of a sample biomarker pattern with the reference biomarker pattern, where transplant outcome for the samples used for the reference biomarkers is known, permits a suggested treatment determination. A computerized system to identify the condition of transplant before or after implantation is also provided.

US Patent:

20040096813, May 20, 2004

Filed:

Nov 18, 2002

Appl. No.:

10/298497

Inventors:

John Baust - Candor NY, US
Robert VanBuskirk - Apalachian NY, US
Aby Mathew - Binghamton NY, US

Assignee:

BioLife Solutions, Inc.

International Classification:

A01N001/02

US Classification:

435/002000

Abstract:

The invention provides methods for the hypothermic preservation of cells, tissues and organs. In particular, the invention provides methods for the hypothermic preservation or storage of cells, tissues or organs in the vitreous state.

US Patent:

20070048726, Mar 1, 2007

Filed:

Oct 26, 2006

Appl. No.:

11/553245

Inventors:

John Baust - Owego NY, US
Robert Van Buskirk - Apalachin NY, US
John Baust - Candor NY, US
Kristi Snyder - Vestal NY, US
Aby Mathew - Vestal NY, US

Assignee:

BIOLIFE SOLUTIONS, INC. - Owego NY

International Classification:

A01N 1/02

US Classification:

435001100, 435002000

Abstract:

Gel-based medium compositions and a method of use thereof in normothermic, hypothermic or cryopreservative storage and transport of cell samples are described. These gel-based compositions preferably include an agent that inhibits apoptosis, together with a gelling agent. Such gel-based medium compositions protect various cell samples, such as animal or plant organs, tissues and cells, from the mechanical, physiological and biochemical stresses inherently associated with liquid preservation techniques.

US Patent:

20090149335, Jun 11, 2009

Filed:

Jun 27, 2008

Appl. No.:

12/147884

Inventors:

Aby J. Mathew - Vestal NY, US
Robert Van Buskirk - Apalachin NY, US
John G. Baust - Candor NY, US
John M. Baust - Owego NY, US
Dominic Clarke - Bothell WA, US
Ian Nicoud - Seattle WA, US

Assignee:

BIOLIFE SOLUTIONS INC. - Bothell WA

International Classification:

C40B 50/00
C40B 30/00

US Classification:

506 7, 506 23

Abstract:

The present invention is directed to systems and proteogenomic methods for predicting the success of the transplant of a cell, tissue, or organ by providing a means to determine the quality of the cell, tissue, or organ to be transplanted. In one embodiment, the present invention uses samples from the preservation solution to obtain phenomic fingerprints correlated with transplant pre-operative and post-operative data as a pre-operative tissue diagnostic and procedural success predictive indicator.

US Patent:

20100305000, Dec 2, 2010

Filed:

Aug 13, 2010

Appl. No.:

12/855805

Inventors:

Aby J. Mathew - Vestal NY, US
Robert Van Buskirk - Apalachin NY, US
John G. Baust - Candor NY, US
John M. Baust - Owego NY, US
Dominic M. Clarke - Bothell WA, US
Ian B. Nicoud - Seattle WA, US

Assignee:

Biolife Solutions Inc. - Bothell WA

International Classification:

C40B 30/04
C12Q 1/02
C12Q 1/68

US Classification:

506 9, 435 29, 435 6

Abstract:

The present invention is directed to systems and proteogenomic methods for predicting the success of the transplant of a cell, tissue, or organ by providing a means to determine the quality of the cell, tissue, or organ to be transplanted. In one embodiment, the present invention uses samples from the preservation solution to obtain phenomic fingerprints correlated with transplant pre-operative and post-operative data as a pre-operative tissue diagnostic and procedural success predictive indicator.

US Patent:

20120040450, Feb 16, 2012

Filed:

Apr 29, 2010

Appl. No.:

13/265959

Inventors:

Dominic M. Clarke - Bothell WA, US
Ian B. Nicoud - Seattle WA, US
Aby J. Mathew - Bothell WA, US
Michael Rice - Woodinville WA, US

Assignee:

BIOLIFE SOLUTIONS, INC. - Bothell WA

International Classification:

C12M 1/00

US Classification:

4353071

Abstract:

Provided are apparatuses for cryopreserving cells which include a vessel comprising a biocompatible substrate, wherein the vessel further comprises an interior and an exterior, and a mechanical ice nucleating device disposed in or on the vessel interior for initiating ice crystal formation. Also provided are kits comprising one or more apparatuses for cryopreserving cells and a biopreservation medium. Further provided are compositions comprising a vessel for holding cells, a mechanical ice nucleating device, a biopreservation medium, and cells disposed in the vessel. The apparatuses, kits, and compositions of the invention can optionally include an insulating material which is disposed on all or a portion of the vessel.

US Patent:

20160338907, Nov 24, 2016

Filed:

May 19, 2016

Appl. No.:

15/158717

Inventors:

- Bothell WA, US
Bruce McCormick - Santa Fe NM, US
Aby J. Mathew - Bothell WA, US
Kevin O'Donnell - Arlington Heights IL, US

International Classification:

A61J 1/00
H04Q 9/00

Abstract:

In some embodiments, alerts are sent to appropriate parties if an insulated container is not properly packed out to insure the approximate safe temperature of the materials. In other embodiments, a countdown timer is used to keep track of the time that the biologic has been in transit, and ensure that the amount of time does not exceed the known shelf life of the biologic. In still other embodiments, the payload container is equipped with its own sensors, such as temperature sensors, and communications devices, such as a close range communication device, capable of transmitting information regarding a range of parameters, including, but not limited to, temperature, humidity, location and time, from the payload container to an end user. In other embodiments, shielding and/or radiation sensors are included in insulated shipping or storage containers, or payload containers, to shield and monitor the radiation exposure of the payload.