Albrecht Josipa Moritz

US Patent:

7888480, Feb 15, 2011

Filed:

Feb 29, 2008

Appl. No.:

12/074224

Inventors:

Roberto Polakiewicz - Lexington MA, US
Valerie Goss - Seabrook NH, US
Albrecht Moritz - Salem MA, US
Kimberly Lee - Seattle WA, US

Assignee:

Cell Signaling Technology, Inc. - Danvers MA

International Classification:

C07K 16/00

US Classification:

5303879

Abstract:

The invention discloses nearly 288 novel phosphorylation sites identified in signal transduction proteins and pathways underlying human Leukemia, and provides phosphorylation-site specific antibodies and heavy-isotope labeled peptides (AQUA peptides) for the selective detection and quantification of these phosphorylated sites/proteins, as well as methods of using the reagents for such purpose. Among the phosphorylation sites identified are sites occurring in the following protein types: Adaptor/Scaffold proteins, Cytoskeletal proteins, Cellular Metabolism enzymes, G Protein/GTPase Activating/Guanine Nucleotide Exchange Factor proteins, Immunoglobulin Superfamily proteins, Inhibitor proteins, Lipid Kinases, Nuclear DNA Repair/RNA Binding/Transcription proteins, Serine/Threonine Protein Kinases, Tyrosine Kinases, Protein Phosphatases, and Translation/Transporter proteins.

US Patent:

7935790, May 3, 2011

Filed:

Aug 11, 2006

Appl. No.:

11/503336

Inventors:

Albrecht Moritz - Salem MA, US
Roberto Polakiewicz - Lexington MA, US
John Edward Rush - Beverly MA, US
Kimberly Lee - Seattle WA, US

Assignee:

Cell Singaling Technology, Inc. - Danvers MA

International Classification:

C07K 16/00
C07K 16/18

US Classification:

5303871, 5303879

Abstract:

The invention discloses 95 novel phosphorylation sites identified in signal transduction proteins and pathways downstream of the T-cell receptor, and provides phosphorylation-site specific antibodies and heavy-isotope labeled peptides (AQUA peptides) for the selective detection and quantification of these phosphorylated sites/proteins, as well as methods of using the reagents for such purpose. Among the phosphorylation sites identified are sites occurring in the following protein types: Actin Binding proteins, Adaptor/Scaffold proteins, Adhesion proteins, Calcium-binding proteins, Cell Cycle Regulation or Channel proteins, Chaperones, Cofactor proteins, Cytoskeletal proteins, DNA Binding proteins, G protein or GTPase Activating proteins, Ligases, Lipid Kinases and Binding proteins, Oxidoreductases, Protein Kinases, Protein Phosphatases, Receptor proteins, RNA Binding proteins, Transcription Factor/Initiation Complex proteins, Transcription Coactivator/Corepressor proteins, Translation Initiation Complex proteins, Ubitquitin Conjugating System proteins, and Vesicle proteins.

US Patent:

7939636, May 10, 2011

Filed:

Aug 11, 2006

Appl. No.:

11/503335

Inventors:

Albrecht Moritz - Salem MA, US
Kimberly Lee - Seattle WA, US
John Rush - Beverly MA, US
Roberto Polakiewicz - Lexington MA, US

Assignee:

Cell Signaling Technology, Inc. - Danver MA

International Classification:

G07K 16/00
G07K 16/18

US Classification:

5303871, 5303879

Abstract:

The invention discloses 102 novel phosphorylation sites identified in signal transduction proteins and pathways downstream of c-Src kinase, and provides phosphorylation-site specific antibodies and heavy-isotope labeled peptides (AQUA peptides) for the selective detection and quantification of these phosphorylated sites/proteins, as well as methods of using the reagents for such purpose. Among the phosphorylation sites identified are sites occurring in the following protein types: Adaptor/Scaffold proteins, Actin Binding proteins, Cytoskeletal proteins, G protein/GTPase Activating protein/Guanine Nucleotide Exchange Factor proteins, Helicases, RNA Binding proteins, Transcription/Translation Factor or Initiation Complex proteins, Cellular Metabolism Enzymes, and Vesicle proteins.

US Patent:

7973134, Jul 5, 2011

Filed:

Aug 11, 2006

Appl. No.:

11/503096

Inventors:

Albrecht Moritz - Salem MA, US
Kimberly Lee - Seattle WA, US
John Rush - Beverly MA, US
Roberto Polakiewicz - Lexington MA, US

Assignee:

Cell Signaling Technology, Inc. - Danvers MA

International Classification:

C07K 16/00
C07K 16/18

US Classification:

5303871, 5303879

Abstract:

The invention discloses 211 novel phosphorylation sites identified in signal transduction proteins and pathways underlying Anaplastic Large Cell Lymphoma (ALCL) involving the ALK-NPM translocation/fusion, and provides phosphorylation-site specific antibodies and heavy-isotope labeled peptides (AQUA peptides) for the selective detection and quantification of these phosphorylated sites/proteins, as well as methods of using the reagents for such purpose. Among the phosphorylation sites identified are sites occurring in the following protein types: Protein Kinases (including Receptor Tyrosine Kinases), Adaptor/Scaffold Proteins, Cellular Metabolism or Miscellaneous Enzymes, Oxidoreductases, Transcription Factors, Cytoskeletal Proteins, Translation Initiation Complexes, RNA Binding Proteins, Proteases, Acetyltransferases, G protein regulators/GTPases, Helicases, Apoptosis/Cell Cycle Regulation proteins, and Hydrolases.

US Patent:

7977462, Jul 12, 2011

Filed:

Apr 18, 2008

Appl. No.:

12/148547

Inventors:

Peter Hornbeck - Magnolia MA, US
Ailan Guo - Burlington MA, US
Klarisa Rikova - Reading MA, US
Albrecht Moritz - Salem MA, US
Charles Farnsworth - Concord MA, US
Matthew Stokes - Beverly MA, US
Jian Yu - Hamilton MA, US
Erik Spek - Cambridge MA, US
Yu Li - Andover MA, US
Anthony Possemato - Framingham MA, US
Jessica Cherry - Durham NH, US
Valerie Goss - Seabrook NH, US
Jeffrey Mitchell - Nashua NH, US
John Rush - Beverly MA, US
Corinne Michaud - Salem MA, US

Assignee:

Cell Signaling Technology, Inc. - Danvers MA

International Classification:

C07K 16/00
C12P 21/08

US Classification:

5303871, 5303877, 5303879, 5303881, 5303888, 53038885, 5303891, 5303897

Abstract:

The invention discloses 482 novel phosphorylation sites identified in carcinoma and/or leukemia, peptides (including AQUA peptides) comprising a phosphorylation site of the invention, antibodies specifically bind to a novel phosphorylation site of the invention, and diagnostic and therapeutic uses of the above.

US Patent:

7999080, Aug 16, 2011

Filed:

Jul 13, 2007

Appl. No.:

12/309310

Inventors:

Peter Hornbeck - Magnolia MA, US
Valerie Goss - Seabrook NH, US
Kimberly Lee - Seattle WA, US
Albrecht Moritz - Salem MA, US

Assignee:

Cell Signaling Technology, Inc. - Danvers MA

International Classification:

C07K 16/18

US Classification:

5303879

Abstract:

The invention discloses novel phosphorylation sites identified in signal transduction proteins and pathways, and provides phosphorylation-site specific antibodies and heavy-isotope labeled peptides (AQUA peptides) for the selective detection and quantification of these phosphorylated sites/proteins, as well as methods of using the reagents for such purpose. Among the phosphorylation sites identified are sites occurring in the following protein types: adaptor/scaffold proteins, adhesion/extracellular matrix protein, apoptosis proteins, calcium binding proteins, cell cycle regulation proteins, chaperone proteins, chromatin, DNA binding/repair/replication proteins, cytoskeletal proteins, endoplasmic reticulum or golgi proteins, enzyme proteins, G/regulator proteins, inhibitor proteins, motor/contractile proteins, phosphatase, protease, Ser/Thr protein kinases, Protein kinase (Tyr)s, receptor/channel/cell surface proteins, RNA binding proteins, transcriptional regulators, tumor suppressor proteins, ubiquitan conjugating system proteins and proteins of unknown function.

US Patent:

8618260, Dec 31, 2013

Filed:

Sep 8, 2007

Appl. No.:

12/310852

Inventors:

Peter Hornbeck - Magnolia MA, US
Albrecht Moritz - Salem MA, US
John Rush - Beverly MA, US
Steven Gygi - Boston MA, US

Assignee:

Cell Signaling Technology, Inc. - Danvers MA

International Classification:

C07K 16/00

US Classification:

5303871

Abstract:

The invention discloses 155 novel phosphorylation sites identified in carcinoma and leukemia, peptides (including AQUA peptides) comprising a phosphorylation site of the invention, antibodies specifically bind to a novel phosphorylation site of the invention, and diagnostic and therapeutic uses of the above.

US Patent:

20030186254, Oct 2, 2003

Filed:

Apr 29, 2002

Appl. No.:

10/134102

Inventors:

Michael Melnick - Belmont MA, US
Albrecht Moritz - Salem MA, US
Michael Comb - Manchester MA, US

Assignee:

CELL SIGNALING TECHNOLOGY, INC.

International Classification:

C12Q001/70
C12Q001/68
C12P019/34
C12N007/00
C12N007/01
C12N005/06
C12N005/16

US Classification:

435/006000, 435/091100, 435/235100, 435/345000

Abstract:

The present invention discloses complexes of cellular signaling proteins that interact in vivo with the HIV-encoded auxiliary proteins Nef and Tat to modulate their activity. This complex includes the novel serine/threonine kinase PAK4 and the novel guanine nucleotide exchange factor Cdc42-GEF, which synergize to stimulate Tat transcriptional activity, and the acetyl-transferase Tip60 which modifies Nef. These cellular partners of the HIV auxiliary proteins represent novel targets for HIV therapeutics. The invention provides isolated DNA and vectors encoding PAK4 and Cdc42-GEF, and methods of producing recombinant forms of these proteins. The invention also provides methods for identifying compounds that modulate the activity of HIV-Tat, HIV-Nef or Tip60, and methods for modulating the activity of these enzymes.

Author:

Albrecht Moritz

ISBN #:

3261014091