Allen B Reitz

US Patent:

6358946, Mar 19, 2002

Filed:

Jul 20, 2000

Appl. No.:

09/619804

Inventors:

Allen B. Reitz - Lansdale PA
Samuel O. Nortey - Elkins PA
Pauline Sanfilippo - Flemington NJ
Malcolm K. Scott - Lansdale PA

Assignee:

Ortho-McNeil Pharmaceutical, Inc. - Raritan NJ

International Classification:

C07D47104

US Classification:

5142282, 546 19, 546 86, 514278, 514292, 5142332, 51425305, 544126, 544361, 544 586

Abstract:

A C-6 ring-substituted pyrido[1,2-a]benzimidazole derivative of the formula: methods of preparation and pharmaceutical compositions containing a substituted pyrido[1,2-a]benzimidzole derivative as the active ingredient are disclosed. The substituted pyrido[1,2-a]benzimidazole derivatives are useful in the treatment of central nervous system disorders.

US Patent:

6407136, Jun 18, 2002

Filed:

May 2, 2000

Appl. No.:

09/563147

Inventors:

Malcolm K. Scott - Lansdale PA
Daniel H. S. Lee - Northampton PA
Allen B. Reitz - Lansdale PA
Tina Morgan Ross - Audubon PA

Assignee:

Ortho-McNeil Pharmaceutical, Inc. - Raritan NJ

International Classification:

A61K 31385

US Classification:

514436, 514431, 549 11, 549 21

Abstract:

The invention is directed to 1,4-dithiin- and 1,4-dithiepin-1,1,4,4-tetroxide derivatives useful as galanin receptor antagonists for treating disorders of the central nervous system. Pharmaceutical compositions comprising the compounds of the present invention and methods of treating conditions such as an eating disorder, obesity, bulimia nervosa, anorexia nervosa, binge eating, diabetes, dyslipidemia, hypertension, memory loss, sleep disturbances, pain, depression, anxiety, Alzheimers disease, senile dementia, cerebral hemorrhage, or diarrhea are also described.

US Patent:

6436959, Aug 20, 2002

Filed:

Dec 23, 1998

Appl. No.:

09/220189

Inventors:

John R. Carson - Norristown PA
Richard J. Carmosin - late of Quakertown PA
Louis J. Fitzpatrick - Souderton PA
Allen B. Reitz - Lansdale PA
Michele C. Jetter - Norristown PA

Assignee:

Ortho-McNeil Pharmaceutical, Inc. - Raritan NJ

International Classification:

A61K 314468

US Classification:

514326, 514329, 546224, 546208

Abstract:

4-[aryl(piperidin-4-yl)]aminobenzamides are delta-opioid receptor agonists/antagonists. As delta-opioid receptor agonists, such compounds are useful as analgesics. Depending on their agonist/antagonist effect, such compounds may also be useful immunosuppressants, antiinflammatory agents, agents for the treatment of mental illness, medicaments for drug and alcohol abuse, agents for treating gastritis and diarrhea, cardiovascular agents, and agents for the treatment of respiratory diseases.

US Patent:

6441049, Aug 27, 2002

Filed:

May 27, 1999

Appl. No.:

09/320885

Inventors:

Allen B. Reitz - Lansdale PA
David A. Demeter - Fishers IN
Daniel H. S. Lee - Northhampton PA
Hoau-Yan Wang - Philadelphia PA
Robert H. Chen - Belle Mead NJ
Tina Morgan Ross - Audubon PA
Malcolm K. Scott - Lansdale PA
Carlos R. Plata-Salaman - Ambler PA

Assignee:

Ortho-McNeil Pharmaceutical, Inc. - Raritan NJ

International Classification:

A61K 31135

US Classification:

514657, 564428, 564429

Abstract:

The invention is directed to a method of treating a neurodegenerative disorder in a subject in need thereof which comprises administering to the subject an amount of a compound effective to inhibit the interaction of amyloid-beta with alpha-7 nicotinic acetylcholine receptors.

US Patent:

6465486, Oct 15, 2002

Filed:

Mar 10, 2000

Appl. No.:

09/524451

Inventors:

Ellen W. Baxter - Glenside PA
Robert E. Boyd - Horsham PA
John R. Carson - Norristown PA
Michele C. Jetter - Norristown PA
Allen B. Reitz - Lansdale PA

Assignee:

Ortho-McNeil Pharmaceutical, Inc. - Raritan NJ

International Classification:

A61K 3147

US Classification:

514311, 514314, 546167, 546165, 546178, 5462727, 5462751, 546341

Abstract:

Certain imidazo pyridines/quinolines of the formula: where n is 0, 1, 2; X is independently selected from the group consisting of C alkyl, bromine, chlorine, iodide, trifluoromethyl, C alkoxy, âSO NH , nitro, and two adjacent X may be fused to form the moiety: âwhereby a saturated, partially unsaturated or aromatic six-membered fused ring is formed; Y is independently selected from the group consisting of hydrogen, hydroxy, C alkyl, C alkoxy, trifluoromethyl and phenyl; and Z is independently selected from the group consisting of hydroxy, C alkyl, bromine, chlorine, iodide, trifluoromethyl, C alkoxy, âSO NH and nitro; are -adrenoceptor modulators which are useful in the treatment of hypertension, glaucoma, sexual dysfunction, depression, attention deficit hyperactivity disorder, Parkinsonism, the need for anesthesia, cardiac arrythmia or the need for analgesia.

US Patent:

6511998, Jan 28, 2003

Filed:

Jul 3, 2001

Appl. No.:

09/898420

Inventors:

Cheryl P. Kordik - Lansdale PA 19446
Timothy W. Lovenberg - San Diego CA 92130
Allen B. Reitz - Lansdale PA 19446

International Classification:

C07D40102

US Classification:

514341, 514406, 5462754, 5483741

Abstract:

Pyrazole carboxamide derivatives of the formula: which are ligands for the neuropeptide Y, subtype 5 receptor, and pharmaceutical compositions containing a pyrazole carboxamide derivative as the active ingredient are described. The pyrazole carboxamides are useful in the treatment of disorders and diseases associated with the NPY receptor subtype Y5.

US Patent:

6531478, Mar 11, 2003

Filed:

Feb 22, 2001

Appl. No.:

09/791203

Inventors:

Cheryl P. Kordik - Lansdale PA 19446
Scott L. Dax - Landenberg PA 19350
Chi Luo - Lansdale PA 19004
Allen B. Reitz - Lansdale PA 19446
James J. McNally - Souderton PA 18964
Timothy W. Lovenberg - San Diego CA 92101

International Classification:

A61K 31415

US Classification:

514275, 514307, 514310, 514311, 514314, 514341, 514404, 514407, 544331, 546141, 546143, 546146, 546147, 546153, 546162, 546165, 546168, 5462754, 5483714, 5483717, 5483725

Abstract:

Amino pyrazole derivatives of the formula: which are ligands for the neuropeptide Y, subtype 5 receptor and pharmaceutical compositions containing an amino pyrazole derivative as the active ingredient are described. The amino pyrazole derivatives are useful in the treatment of disorders and diseases associated with the NPY receptor subtype Y5.

US Patent:

6593474, Jul 15, 2003

Filed:

Jun 12, 2000

Appl. No.:

09/591814

Inventors:

Linda Jolliffe - Belle Mead NJ
William Murray - Belle Mead NJ
Virginia Pulito - Flemington NJ
Linda Mulcahy - Flemington NJ
Xiaobing Li - San Diego CA
Allen Reitz - Lansdale PA
Cynthia Maryanoff - Forest Grove PA
Frank Villani - Perkasie PA

Assignee:

Ortho-McNeil Pharmaceutical, Inc. - Raritan NJ

International Classification:

C07D29514

US Classification:

544393, 544230, 544360, 544372, 544373, 544392

Abstract:

This invention relates to a series of arylsubstituted piperazines, of Formula I pharmaceutical compositions containing them and intermediates used in their manufacture. The compounds of the invention selectively inhibit binding to the -1 adrenergic receptor, a receptor which has been implicated in benign prostatic hyperplasia. As such the compounds are potentially useful in the treatment of this and other disease.

Author:

Allen Bernard Reitz

ISBN #:

0841220867

Author:

Allen B. Reitz

ISBN #:

0444510540

Author:

Allen B. Reitz

ISBN #:

0762300647