Michael P. Czech - Westborough MA, US Aimee Powelka - Framingham MA, US Adilson L. Guilherme - Shrewsbury MA, US Andrew D. Cherniack - Shrewsbury MA, US
Assignee:
University of Massachusetts - Boston MA
International Classification:
A61K 48/00
US Classification:
514 44, 536 245, 536 241, 536 2431
Abstract:
Inhibition of RIP140 increases glucose transport. Compounds that inhibit RIP140 expression or activity are useful for treating disorders associated with aberrant glucose transport (e. g. , diabetes), treating obesity, increasing metabolism (e. g. , fatty acid metabolism), and increasing brown fat.
Michael P. Czech - Westborough MA, US Aimee Powelka - Framingham MA, US Adilson L. Guilherme - Shrewsbury MA, US Andrew D. Cherniack - Worcester MA, US
Assignee:
University of Massachusetts - Boston MA
International Classification:
C07H 21/04
US Classification:
536 245, 536 241, 536 2431, 514 44
Abstract:
Inhibition of RIP140 increases glucose transport. Compounds that inhibit RIP140 expression or activity are useful for treating disorders associated with aberrant glucose transport (e. g. , diabetes), treating obesity, increasing metabolism (e. g. , fatty acid metabolism), and increasing brown fat.
Michael Czech - Westborough MA, US Andrew Cherniack - Worcester MA, US Adilson Guilherme - Shrewsbury MA, US
International Classification:
C12Q001/68 C12M001/34
US Classification:
435/006000, 435/287200
Abstract:
Nucleotide sequences and amino acid sequences from nucleic acids and proteins involved in glucose transport are disclosed. The sequences are useful for producing DNA arrays that can be used for the diagnosis of, predictive testing for, and development of treatments for disorders involving glucose transport such as type II diabetes.
Michael Czech - Westborough MA, US Andrew Cherniack - Worcester MA, US Adilson Guilherme - Shrewsbury MA, US
International Classification:
C12Q001/68 C12M001/34
US Classification:
435006000, 435287200
Abstract:
Nucleotide sequences and amino acid sequences from nucleic acids and proteins involved in glucose transport are disclosed. The sequences are useful for producing DNA arrays that can be used for the diagnosis of, predictive testing for, and development of treatments for disorders involving glucose transport such as type II diabetes.
Michael Czech - Westborough MA, US Aimee Powelka - Framingham MA, US Adilson Guilherme - Shrewsbury MA, US Andrew Cherniack - Shrewsbury MA, US
International Classification:
A61K048/00 A61K038/17 A61K039/395
US Classification:
514044000, 514012000, 424143100
Abstract:
Inhibition of RIP140 increases glucose transport. Compounds that inhibit RIP140 expression or activity are useful for treating disorders associated with aberrant glucose transport (e.g., diabetes), treating obesity, increasing metabolism (e.g., fatty acid metabolism), and increasing brown fat.
Dana-Farber Cancer Institute
Group Leader
Broad Institute
Group Leader
Broad Institute 2010 - 2014
Research Scientist Ii
Abbvie 2001 - 2010
Senior Scientist Ii and Senior Scientist Iii
Umass Medical School 1992 - 2001
Post Doc and Research Assistant Professor
Education:
The Ohio State University
Doctorates, Doctor of Philosophy, Genetics
University of Pennsylvania
Bachelors, Bachelor of Arts, Biology
Skills:
Molecular Biology Genomics Genetics Cancer Assay Development Biomarkers Cell Biology Computational Biology Bioinformatics Biotechnology Biochemistry Drug Discovery Clinical Development Cancer Genomics Gene Expression Profiling Life Sciences R Sequence Analysis Microarray Analysis Management
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