- Princeton NJ, US Yan Chen - Yardley PA, US Bireshwar Dasgupta - Doylestown PA, US Andrew P. Degnan - Jamison PA, US Matthew D. Hill - Windham NH, US Godwin Kwame Kumi - Morrisville PA, US Harold A. Mastalerz - Guilford CT, US Mark D. Wittman - Hopkinton MA, US Bradley C. Pearce - East Hampton CT, US Guifen Zhang - Hopkinton MA, US
Disclosed are compounds of Formula (I) or a salt thereof, wherein: X is CH or N; Y is CR5 or N; and R1, R2, R3, R4, and R5 are defined herein. Also disclosed are methods of using such compounds to modulate or inhibit the enzymatic activity of hematopoietic progenitor kinase 1 (HPK1), and pharmaceutical compositions comprising such compounds. These compounds are useful in the treatment of viral infections and proliferative disorders, such as cancer.
5H-Pyrido[3,2-B]Indole Compounds As Anticancer Agents
- Princeton NJ, US Andrew P. Degnan - Jamison PA, US Jeffrey D. Deskus - Marlborough CT, US Ashvinikumar V. Gavai - Princeton Junction NJ, US Patrice Gill - Levittown PA, US William D. Schmitz - Cheshire CT, US
International Classification:
C07D 471/04
Abstract:
The present invention is directed to tricyclic compounds of formula (I), pharmaceutically acceptable compositions comprising compounds of the invention and said compositions for use in methods for the treatment of various disorders in particular cancer.
- Princeton NJ, US Wayne Vaccaro - Yardley PA, US Mikkel V. DeBenedetto - Middletown CT, US Andrew P. Degnan - Rocky Hill CT, US George V. Delucca - Pennington NJ, US Jeffrey A. Deskus - Marlborough CT, US Wen-Ching Han - Newtown PA, US Godwin Kwame Kumi - Rocky Hill CT, US William D. Schmitz - Cheshire CT, US Matthew D. Hill - Wallingford CT, US Hong Huang - Durham CT, US
The present invention is directed to tricyclic compounds of the formulawherein all substituents are defined herein, as well as pharmaceutically acceptable compositions comprising compounds of the invention and methods of using said compositions in the treatment of various disorders.
Radiology Group of Abington P.c
Radiologist
The Children's Hospital of Philadelphia
Staff Radiologist, Research Fellow
The Children's Hospital of Philadelphia Jul 2017 - Jun 2018
Pediatric Radiology Fellow
Temple University School of Medicine Jul 2017 - Jun 2018
Radiologist, Part-Time Emergency Imaging
Upmc Jul 2013 - Jul 2017
Chief Radiology Resident
Education:
The George Washington University School of Medicine and Health Sciences 2007 - 2012
Doctor of Medicine, Doctorates, Medicine
University of Cambridge 2010 - 2011
The George Washington University 2004 - 2007
Bachelors, Bachelor of Science, Biology
La Salle College High School 2000 - 2004
Skills:
Clinical Research Medicine Medical Education Radiology Internal Medicine Medical Imaging Research Public Health Healthcare Mri Hospitals Neurology Neuroscience Epidemiology Healthcare Information Technology Health Policy Pediatric Radiology
Certifications:
American Board of Magnetic Resonance Safety Magnetic Resonance Medical Director (Mrmd)/Magnetic Resonance Physician, Magnetic Resonance Safety Certified (Mrsc™) Diplomate of the American Board of Radiology (Dabr)
Bristol-Myers Squibb
Principal Investigator In Oncology Chemistry
Education:
University of Pennsylvania Jan 1, 2000 - 2002
Colorado State University Jan 1, 1995 - 1999
Doctorates, Doctor of Philosophy, Philosophy, Organic Chemistry
University of Maryland Baltimore County Jan 1, 1991 - 1995
Bachelors, Bachelor of Science, Chemistry
Broadneck Senior High