Chemocentryx 2002 - 2016
Executive Director, Preclinical Drug Development; Director, Medicinal Chemistry; Act Director Dmpk
Arcus Biosciences 2002 - 2016
Vice President, Preclinical and Small Molecule Pharmaceutical Development
Genesoft Inc. 2000 - 2002
Director of Medicinal Chemistry
Glaxosmithkline Pharma Gmbh 1993 - 2000
Group Leader, Medicinal Chemistry Department Management Team; Vessel Wall Disease Chemistry Leader
Columbia University In the City of New York 1991 - 1993
Postdoctoral Scientist
Education:
Dyson School of Design Engineering 1987 - 1990
Doctorates, Doctor of Philosophy, Organic Chemistry
Dyson School of Design Engineering 1984 - 1987
Bachelors, Bachelor of Science, Chemistry
Skills:
Medicinal Chemistry Chemistry Drug Development Drug Discovery Organic Synthesis Drug Design Pharmaceutical Industry Preclinical Development Pharmaceutical Development
Solomon Ungashe - Fremont CA, US Zheng Wei - Redwood City CA, US John Jessen Wright - Redwood City CA, US Andrew Pennell - San Francisco CA, US
Assignee:
Chemocentryx - Mountain View CA
International Classification:
C07D213/20 A51K031/4425
US Classification:
514358, 546347
Abstract:
Compounds are provided that act as potent antagonists of the CCR9 receptor, and which have been further confirmed in animal testing for inflammation, one of the hallmark disease states for CCR9. The compounds are generally aryl sulfonamide derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR9-mediated diseases, and as controls in assays for the identification of CCR9 antagonists.
Solomon Ungashe - Fremont CA, US Zheng Wei - Redwood City CA, US J. J. Wright - Redwood City CA, US Andrew Pennell - San Francisco CA, US Brett Permack - San Francisco CA, US Thomas Schall - Palo Alto CA, US
Compounds are provided that act as potent antagonists of chemokine receptors. The compounds are generally aryl sulfonamide derivatives and are useful in pharmaceutical compositions, methods for the treatment of chemokine receptor-mediated diseases, and as controls in assays for the identification of chemokine antagonists.
Solomon Ungashe - Fremont CA, US Zheng Wei - Redwood City CA, US John J. Wright - Redwood City CA, US Andrew Pennell - San Francisco CA, US Brett Permack - San Francisco CA, US Thomas Schall - Palo Alto CA, US
Compounds are provided that act as potent antagonists of chemokine receptors. The compounds are generally aryl sulfonamide derivatives and are useful in pharmaceutical compositions, methods for the treatment of chemokine receptor-mediated diseases, and as controls in assays for the identification of chemokine antagonists.
Solomon Ungashe - Fremont CA, US J. J. Wright - Redwood City CA, US Andrew Pennell - San Francisco CA, US Zheng Wei - Union City CA, US Anita Melikan - San Francisco CA, US
Assignee:
Chemocentryx, Inc. - Mountain View CA
International Classification:
C07D 413/10
US Classification:
544124, 5462714, 5142352, 514340
Abstract:
Compounds are provided that act as potent antagonists of the CCR9 receptor, and which have been further confirmed in animal testing for inflammation, one of the hallmark disease states for CCR9. The compounds are generally aryl sulfonamide derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR9-mediated diseases, and as controls in assays for the identification of CCR9 antagonists.
Andrew M.K. Pennell - San Francisco CA, US James B. Aggen - Burlingame CA, US J.J. Kim Wright - Redwood City CA, US Brian E. McMaster - Mountain View CA, US Daniel Joseph Dairaghi - Palo Alto CA, US
Assignee:
ChemoCentryx, Inc. - Mountain View CA
International Classification:
C07D 401/12 C07D 403/12
US Classification:
544238, 544295, 544357, 544364
Abstract:
Compounds are provided that act as potent antagonists of the CCR1 receptor, and which have been further confirmed in animal testing for inflammation, one of the hallmark disease states for CCR1. The compounds are generally aryl piperazine derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR1-mediated diseases, and as controls in assays for the identification of competitive CCR1 antagonists.
Zheng Wei - Redwood City CA, US John J. Wright - Redwood City CA, US Andrew Pennell - San Francisco CA, US
Assignee:
ChemoCentryx, Inc. - San Carlos CA
International Classification:
A61K 31/4425 C07D 213/20
US Classification:
514354, 546314
Abstract:
Compounds are provided that act as potent antagonists of the CCR9 receptor, and which have been further confirmed in animal testing for inflammation, one of the hallmark disease states for CCR9. The compounds are generally aryl sulfonamide derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR9-mediated diseases, and as controls in assays for the identification of CCR9 antagonists.
Solomon Ungashe - Fremont CA, US Zheng Wei - Redwood City CA, US John J. Wright - Redwood City CA, US Andrew Pennell - San Francisco CA, US Brett Permack - San Francisco CA, US Thomas Schall - Palo Alto CA, US
Compounds are provided that act as potent antagonists of chemokine receptors. The compounds are generally aryl sulfonamide derivatives and are useful in pharmaceutical compositions, methods for the treatment of chemokine receptor-mediated diseases, and as controls in assays for the identification of chemokine antagonists.
The present invention relates to compounds that modulate various chemokine receptors. These compounds are useful for treating inflammatory and immune diseases.
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Andrew Pennell
Andrew Pennell
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Marietta, GeorgiaSr.Director, Medical Science at King Pharmaceutica... Past: Field Medical Director at Boston Scientific Corporation, Medical Science at Bristol-Myers...