Ronald M. Evans - La Jolla CA, US Michael B. McKeown - San Diego CA, US Anthony E. Oro - San Diego CA, US William A. Segraves - Ambler PA, US Tso-Pang Yao - La Jolla CA, US
Assignee:
The Salk Institute for Biological Studies - La Jolla CA
International Classification:
C07H 21/04 A61K 48/00
US Classification:
514 44, 435 6, 435440, 435375
Abstract:
In accordance with the present invention, it has been discovered that various members of the steroid/thyroid superfamily of receptors can interact with the insect-derived ultraspiracle receptor, to form multimeric species. Accordingly, the interaction of at least one member of the steroid/thyroid superfamily of receptors with at least the dimerization domain of the ultraspiracle receptor modulates the ability of said member of the steroid/thyroid superfamily of receptors to transactivate transcription of genes maintained under hormone expression control in the presence of the cognate ligand for said member of the superfamily.
Drosophila Derived Receptors Of The Steroid Receptor Superfamily
RONALD M. EVANS - LA JOLLA CA, US ESTELITA S. ONG - SAN DIEGO CA, US ANTHONY E. ORO - SAN DIEGO CA, US
International Classification:
G01N033/53 G01N033/567
US Classification:
435/007210, 435/007200
Abstract:
Disclosed is an identified model Drosophila melanogaster receptor, characterized and described for potential use for identifying other related polypeptides and for use in assays to screen and develop potential anthelmintics, for example.
Bone Morphogenetic Protein Antagonist And Uses Thereof
The present invention relates to the use of proteins that are differentially expressed in tumor associated stromal cells, as compared to normal stromal, as biomolecular targets for tumor treatment therapies. The present invention also provides compounds and pharmaceutically acceptable compositions for administration in the methods of the invention.
Inhibitors Of Atypical Protein Kinase C And Their Use In Treating Hedgehog Pathway-Dependent Cancers
Methods and compositions are provided for modulating Hedgehog (Hh) pathway signaling in a cell. Aspects of the methods include methods for inhibiting Hh pathway-promoted cancer proliferation and/or metastasis that is promoted by Hh pathway signaling, methods for treating cancers promoted by Hh pathway signaling, and methods for screening candidate agents for the ability to treat a cancer promoted by Hh pathway signaling. In addition, reagents and kits thereof that find use in practicing the subject methods are provided.
Insect Retinoid-Like Receptor Compositions And Methods
Anthony E. Oro - San Diego CA Ronald M. Evans - La Jolla CA
Assignee:
The Salk Institute for Biological Studies - La Jolla CA
International Classification:
C12P 2106 C12N 500 C07K 100
US Classification:
435 691
Abstract:
The present invention relates to the discovery of novel insect receptor polypeptides, which, when complexed with certain ligands, or otherwise activated by certain compounds, modulate transcription of certain genes by binding to cognate response elements associated with the promoters of the genes. The novel receptors of the invention are substantially similar to previously discovered mammalian receptors which are activated to modulate transcription of certain genes in cells, when the cells are exposed to retinoic acid. The invention provides DNAs encoding the novel receptors, including expression vectors for expression of the receptors in cells; cells transformed with such expression vectors; cells co-transformed with such expression vectors and with reporter vectors to monitor activation of the receptors to modulate transcription, when the cells are exposed to ligand for the invention receptor; and methods of using such co-transformed cells in screening for compounds which are capable of leading to activation of the receptors and for compounds which are capable of interfering with such activation and, as such, are potentially potent insecticides. The invention also provides DNA and RNA probes for identifying DNA's encoding related receptors, of insects and other animals, of the class, to which the novel receptors of the invention belong.
Ronald M. Evans - La Jolla CA David J. Mangelsdorf - San Diego CA Estelita S. Ong - San Diego CA Anthony E. Oro - San Diego CA Uwe K. Borgmeyer - Hamburg, DE Vincent Giguere - Etobicoke, CA Tso-Pang Yao - San Diego CA
Assignee:
The Salk Institute for Biological Studies - La Jolla CA
International Classification:
C12P 2106 C12N 500 C12N 1500 C07H 1700
US Classification:
435 691
Abstract:
Novel members of the steroid/thyroid superfamily of receptors are described. DNA sequences encoding same, expression vectors containing such DNA and host cells transformed with such expression vectors are also disclosed, as are methods for the expression of the novel receptors of the invention, and various uses thereof.
Methods Of Using Novel Steroid Hormone Orphan Receptors
Ronald M. Evans - La Jolla CA David J. Mangelsdorf - San Diego CA Estelita S. Ong - San Diego CA Anthony E. Oro - San Diego CA Uwe K. Borgmeyer - Hamburg, DE Vincent Giguere - Etobicoke, CA Tso-Pang Yao - San Diego CA
Assignee:
The Salk Institute for Biological Studies - La Jolla CA
International Classification:
C12Q 168 C12P 2106 C07K 1400
US Classification:
435 6
Abstract:
Novel members of the steroid/thyroid superfamily of receptors are described. DNA sequences encoding same, expression vectors containing such DNA and host cells transformed with such expression vectors are also disclosed, as are methods for the expression of the novel receptors of the invention, and various uses thereof.
Multimeric Forms Of Members Of The Steroid/Thyroid Superfamily Of Receptors With The Ultraspiracle Receptor
Ronald M. Evans - La Jolla CA Michael B. Mc Keown - San Diego CA Anthony E. Oro - San Diego CA William A. Segraves - Ambler PA Tso-Pang Yao - La Jolla CA
Assignee:
The Salk Institute Biological Studies - San Diego CA
International Classification:
C07K 500
US Classification:
530324
Abstract:
In accordance with the present invention, it has been discovered that various members of the steroid/thyroid superfamily of receptors can interact with the insect-derived ultraspiracle receptor, to form multimeric species. Accordingly, the interaction of at least one member of the steroid/thyroid superfamily of receptors with at least the dimerization domain of the ultraspiracle receptor modulates the ability of said member of the steroid/thyroid superfamily of receptors to transactivate transcription of genes maintained under hormone expression control in the presence of the cognate ligand for said member of the superfamily.
Medicine Doctors
Dr. Anthony E Oro, Redwood City CA - MD (Doctor of Medicine)
Dr. Oro graduated from the University of California, San Diego School of Medicine in 1993. He works in Redwood City, CA and specializes in Dermatology. Dr. Oro is affiliated with Stanford Hospital.