Anthony E Oro

US Patent:

7119077, Oct 10, 2006

Filed:

Mar 15, 2000

Appl. No.:

09/526298

Inventors:

Ronald M. Evans - La Jolla CA, US
Michael B. McKeown - San Diego CA, US
Anthony E. Oro - San Diego CA, US
William A. Segraves - Ambler PA, US
Tso-Pang Yao - La Jolla CA, US

Assignee:

The Salk Institute for Biological Studies - La Jolla CA

International Classification:

C07H 21/04
A61K 48/00

US Classification:

514 44, 435 6, 435440, 435375

Abstract:

In accordance with the present invention, it has been discovered that various members of the steroid/thyroid superfamily of receptors can interact with the insect-derived ultraspiracle receptor, to form multimeric species. Accordingly, the interaction of at least one member of the steroid/thyroid superfamily of receptors with at least the dimerization domain of the ultraspiracle receptor modulates the ability of said member of the steroid/thyroid superfamily of receptors to transactivate transcription of genes maintained under hormone expression control in the presence of the cognate ligand for said member of the superfamily.

US Patent:

20020102618, Aug 1, 2002

Filed:

Apr 19, 1995

Appl. No.:

08/425716

Inventors:

RONALD M. EVANS - LA JOLLA CA, US
ESTELITA S. ONG - SAN DIEGO CA, US
ANTHONY E. ORO - SAN DIEGO CA, US

International Classification:

G01N033/53
G01N033/567

US Classification:

435/007210, 435/007200

Abstract:

Disclosed is an identified model Drosophila melanogaster receptor, characterized and described for potential use for identifying other related polypeptides and for use in assays to screen and develop potential anthelmintics, for example.

US Patent:

20090041757, Feb 12, 2009

Filed:

Mar 13, 2008

Appl. No.:

12/075944

Inventors:

Hanson Zhen - Stanford CA, US
Julie Sneddon - Palo Alto CA, US
Patrick O. Brown - Stanford CA, US
Anthony Oro - Stanford CA, US

International Classification:

A61K 39/395
C12Q 1/68
A61P 35/00
A61K 31/711
A61K 31/7105
G01N 33/53

US Classification:

4241301, 435 6, 435 71, 514 44

Abstract:

The present invention relates to the use of proteins that are differentially expressed in tumor associated stromal cells, as compared to normal stromal, as biomolecular targets for tumor treatment therapies. The present invention also provides compounds and pharmaceutically acceptable compositions for administration in the methods of the invention.

US Patent:

20120283194, Nov 8, 2012

Filed:

Mar 16, 2012

Appl. No.:

13/422936

Inventors:

Scott X. Atwood - Stanford CA, US
Anthony Oro - Stanford CA, US

International Classification:

A61K 38/10
A61P 35/00
C12N 15/113
C07K 7/08
C12N 5/09
C07D 403/12
A61K 31/4355
C07D 491/107
A61K 31/45
C07D 211/40
A61K 31/713
A61K 31/496

US Classification:

514 195, 514 193, 514 44 A, 536 245, 530327, 51425405, 544371, 514278, 546 15, 514328, 546219, 435375

Abstract:

Methods and compositions are provided for modulating Hedgehog (Hh) pathway signaling in a cell. Aspects of the methods include methods for inhibiting Hh pathway-promoted cancer proliferation and/or metastasis that is promoted by Hh pathway signaling, methods for treating cancers promoted by Hh pathway signaling, and methods for screening candidate agents for the ability to treat a cancer promoted by Hh pathway signaling. In addition, reagents and kits thereof that find use in practicing the subject methods are provided.

US Patent:

56416520, Jun 24, 1997

Filed:

Jun 5, 1995

Appl. No.:

8/464266

Inventors:

Anthony E. Oro - San Diego CA
Ronald M. Evans - La Jolla CA

Assignee:

The Salk Institute for Biological Studies - La Jolla CA

International Classification:

C12P 2106
C12N 500
C07K 100

US Classification:

435 691

Abstract:

The present invention relates to the discovery of novel insect receptor polypeptides, which, when complexed with certain ligands, or otherwise activated by certain compounds, modulate transcription of certain genes by binding to cognate response elements associated with the promoters of the genes. The novel receptors of the invention are substantially similar to previously discovered mammalian receptors which are activated to modulate transcription of certain genes in cells, when the cells are exposed to retinoic acid. The invention provides DNAs encoding the novel receptors, including expression vectors for expression of the receptors in cells; cells transformed with such expression vectors; cells co-transformed with such expression vectors and with reporter vectors to monitor activation of the receptors to modulate transcription, when the cells are exposed to ligand for the invention receptor; and methods of using such co-transformed cells in screening for compounds which are capable of leading to activation of the receptors and for compounds which are capable of interfering with such activation and, as such, are potentially potent insecticides. The invention also provides DNA and RNA probes for identifying DNA's encoding related receptors, of insects and other animals, of the class, to which the novel receptors of the invention belong.

US Patent:

55716962, Nov 5, 1996

Filed:

Nov 2, 1994

Appl. No.:

8/333358

Inventors:

Ronald M. Evans - La Jolla CA
David J. Mangelsdorf - San Diego CA
Estelita S. Ong - San Diego CA
Anthony E. Oro - San Diego CA
Uwe K. Borgmeyer - Hamburg, DE
Vincent Giguere - Etobicoke, CA
Tso-Pang Yao - San Diego CA

Assignee:

The Salk Institute for Biological Studies - La Jolla CA

International Classification:

C12P 2106
C12N 500
C12N 1500
C07H 1700

US Classification:

435 691

Abstract:

Novel members of the steroid/thyroid superfamily of receptors are described. DNA sequences encoding same, expression vectors containing such DNA and host cells transformed with such expression vectors are also disclosed, as are methods for the expression of the novel receptors of the invention, and various uses thereof.

US Patent:

57100047, Jan 20, 1998

Filed:

Aug 7, 1996

Appl. No.:

8/694501

Inventors:

Ronald M. Evans - La Jolla CA
David J. Mangelsdorf - San Diego CA
Estelita S. Ong - San Diego CA
Anthony E. Oro - San Diego CA
Uwe K. Borgmeyer - Hamburg, DE
Vincent Giguere - Etobicoke, CA
Tso-Pang Yao - San Diego CA

Assignee:

The Salk Institute for Biological Studies - La Jolla CA

International Classification:

C12Q 168
C12P 2106
C07K 1400

US Classification:

435 6

Abstract:

Novel members of the steroid/thyroid superfamily of receptors are described. DNA sequences encoding same, expression vectors containing such DNA and host cells transformed with such expression vectors are also disclosed, as are methods for the expression of the novel receptors of the invention, and various uses thereof.

US Patent:

62813307, Aug 28, 2001

Filed:

Jun 5, 1995

Appl. No.:

8/486403

Inventors:

Ronald M. Evans - La Jolla CA
Michael B. Mc Keown - San Diego CA
Anthony E. Oro - San Diego CA
William A. Segraves - Ambler PA
Tso-Pang Yao - La Jolla CA

Assignee:

The Salk Institute Biological Studies - San Diego CA

International Classification:

C07K 500

US Classification:

530324

Abstract:

In accordance with the present invention, it has been discovered that various members of the steroid/thyroid superfamily of receptors can interact with the insect-derived ultraspiracle receptor, to form multimeric species. Accordingly, the interaction of at least one member of the steroid/thyroid superfamily of receptors with at least the dimerization domain of the ultraspiracle receptor modulates the ability of said member of the steroid/thyroid superfamily of receptors to transactivate transcription of genes maintained under hormone expression control in the presence of the cognate ligand for said member of the superfamily.