Brian Alan Bucher

US Patent:

7897796, Mar 1, 2011

Filed:

Jun 18, 2007

Appl. No.:

11/764362

Inventors:

James H. Johnson - Edenton NC, US
T. G. Sambandam - Uxbridge MA, US
Barry J. Hand - Acton MA, US
Christopher D. Howe - Beverly MA, US
Roland R. Franke - Gloucester MA, US
Brian A. Bucher - Boston MA, US
John S. Juchum - Kingston NH, US
Rex T. Gallagher - Hampton NH, US
Marc A. Plante - Middleton MA, US
Dong S. Yang - Qunicy MA, US

Assignee:

Phyton Holdings, LLC - San Antonio TX

International Classification:

C07D 305/00

US Classification:

549510, 549511

Abstract:

This invention is directed to a method for isolating and/or purifying one or more taxanes from materials comprising taxanes. In one embodiment, the method comprises the steps of: (a) treating a taxane containing material with an amino containing material attached to a solid matrix, such as a polyethyleneimine-bonded silica chromatographic resin; (b) eluting the desired taxane compound from the resin; and (c) recovering the eluted taxane compound.

US Patent:

20040186305, Sep 23, 2004

Filed:

Sep 18, 2003

Appl. No.:

10/664539

Inventors:

James Johnson - Merrimac MA, US
Barry Hand - Acton MA, US
Christopher Howe - Berverly MA, US
Roland Franke - Gloucester MA, US
Brian Bucher - Somerville MA, US
Rex Gallagher - Berverly MA, US
Marc Plant - Danvers MA, US
Edward De Simone - Indianoplis IN, US
Dong Yang - Quincy MA, US

International Classification:

C 07D 3 5/14

US Classification:

549/510000

Abstract:

This invention is directed to a method for isolating and/or purifying one or more taxanes from materials comprising taxanes. In one embodiment, the method comprises the steps of: (a) treating a taxane containing material with an amino containing material attached to a solid matrix, such as a polyethyleneimine-bonded silica chromatographic resin; (b) eluting the desired taxane compound from the resin; and (c) recovering the eluted taxane compound.

US Patent:

20060127510, Jun 15, 2006

Filed:

Jun 30, 2005

Appl. No.:

11/173477

Inventors:

Rex Gallagher - Beverly MA, US
Christopher Howe - Beverly MA, US
Edward Desimone - Indianapolis IN, US
Brian Bucher - Somerville MA, US
Barry Hand - Acton MA, US
Steven Perich - Boulder CO, US
Michael Aeschliman - Archbold OH, US
Ivan Wyse - Archbold OH, US

International Classification:

A61K 36/19
C07D 305/14

US Classification:

424769000, 264109000, 549510000

Abstract:

A process for harvesting yew biomass and a process of making Yew pellets from Yew tree material is disclosed herein. The process for harvesting comprising the steps of (i) harvesting the tops or roots of the Yew tree; (ii) washing the harvested material; (iii) drying the harvested material; and (iv) grinding the harvested material into a fine powder. The process for making Yew pellets comprising the steps of (i) adding from about 1% to about 20% w/w water to the Yew tree material; and (ii) compressing the Yew tree material in a die to form a pellet whereby the resulting pellet has a final moisture content of less than 10% by weight. The yew pellets produced herein are suitable for extracting taxane molecules from the pellets.

US Patent:

20100145080, Jun 10, 2010

Filed:

Feb 12, 2010

Appl. No.:

12/705247

Inventors:

James H. Johnson - Edenton NC, US
Barry J. Hand - Acton MA, US
Christopher D. Howe - Beverly MA, US
Roland R. Franke - Gloucester MA, US
Brian A. Bucher - Boston MA, US
John S. Juchum - Kingston NH, US
Rex T. Gallagher - Hampton NH, US
Marc A. Plante - Middleton MA, US
Dong S. Yang - Quincy MA, US

Assignee:

Phyton Holdings LLC - San Antonio TX

International Classification:

C07D 305/14

US Classification:

549510

Abstract:

Disclosed is a method of crystallizing a taxane comprising combining the taxane and methylene chloride to obtain a solution and adding an anti-solvent to the solution to obtain a crystalline taxane, wherein the anti-solvent is selected from the group consisting of hexane and heptane.

US Patent:

20150005517, Jan 1, 2015

Filed:

Feb 24, 2014

Appl. No.:

14/188416

Inventors:

- San Antonio TX, US
Barry J. Hand - Acton MA, US
Christopher D. Howe - Beverly MA, US
Roland R. Franke - Gloucester MA, US
Brian A. Bucher - Boston MA, US
John S. Juchum - Kingston NH, US
Rex T. Gallagher - Hampton MA, US
Marc A. Plante - Middleton MA, US
Dong S. Yang - Quincy MA, US

Assignee:

Phyton Holdings LLC - San Antonio TX

International Classification:

C07D 305/14

US Classification:

549510

Abstract:

Disclosed is a method of crystallizing a taxane comprising combining the taxane and methylene chloride to obtain a solution and adding an anti-solvent to the solution to obtain a crystalline taxane, wherein the anti-solvent is selected from the group consisting of hexane and heptane.