Brooks B Cochran

US Patent:

6927246, Aug 9, 2005

Filed:

Feb 14, 2002

Appl. No.:

10/075415

Inventors:

Glenn Noronha - Oceanside CA, US
Jonathan Reilly - Reseda CA, US
Joseph C. Walsh - Los Angeles CA, US
Brooks Cochran - Northridge CA, US
Aaron M. Heiss - Orange OH, US
Bill C. Ponder - Fort Worth TX, US
David J. Vachon - Granada Hills CA, US

Assignee:

Medtronic MiniMed, Inc. - Northridge CA

International Classification:

C08K005/55

US Classification:

524184, 525259, 436 95

Abstract:

Improved polymer matrices which incorporate fluorescent biosensor molecules as well as methods of making and using these polymer matrices are described. Such matrices can be used in fluorescent biosensors and biosensor systems, including those which are used in the detection of polyhydroxylated analytes such as glucose. The properties of the polymer matrices of the invention renders biosensors utilizing such matrices particularly well-suited for detecting and measuring in-vivo glucose concentrations.

US Patent:

20020123087, Sep 5, 2002

Filed:

Dec 29, 2000

Appl. No.:

09/753095

Inventors:

David Vachon - Granada Hills CA, US
Brooks Cochran - Sylmar CA, US
Bill Ponder - Valencia CA, US

International Classification:

C12Q001/54
C08G077/32
C08G077/388

US Classification:

435/014000, 525/054100

Abstract:

Disclosed is a biocompatible membrane comprising a hydrophilic polyurea composition. The hydrophilic polyutea composition comprises the product of a reaction mixture comprising (a) an amino terminated polysiloxane, (b) a hydrophilic polymer selected from the group consisting of a diamino terminated copolymer of polypropylene glycol and polyethylene glycol, polyethylene glycol, polypropylene glycol and diamino polyethylene glycol having an average molecular weight of from about 400 to about 2000, and (c) a diisocyanate selected from the group consisting of hexamethylene-1,6-diisocyanate, dicyclohexylmethane 4,4′-diisocyanate, and isophorone diisocyanate, and constituting about 50 mole % of the reaction mixture. In this mixture, (a) and (b) constitute a polymeric portion of the reaction mixture, and the hydrophilic polyurea composition has a ratio of its diffusion coefficient for oxygen to its diffusion coefficient for glucose of from about 2,000 to about 10,000. Also provided are biosensors coated with a membrane of the invention, and methods of using such biosensors to measure an analyte in a tissue of a subject.

US Patent:

20080026473, Jan 31, 2008

Filed:

Jul 25, 2006

Appl. No.:

11/492273

Inventors:

Yunbing Wang - Sunnyvale CA, US
Udo Hoss - Sherman Oaks CA, US
Rajiv Shah - Rancho Palos Verdes CA, US
William P. Van Antwerp - Valencia CA, US
Brooks B. Cochran - Northridge CA, US

International Classification:

G01N 33/48
A61B 5/05
C08G 77/04

US Classification:

436 63, 295921, 422 61, 528 25, 600347

Abstract:

Embodiments of the invention provide analyte sensors having elements designed to modulate their chemical reactions as well as methods for making and using such sensors. In certain embodiments of the invention, the sensor includes a hydrophilic comb-copolymer having a central chain and a plurality of side chains coupled to the central chain, wherein at least one side chain comprises a silicone moiety.

US Patent:

20110152654, Jun 23, 2011

Filed:

Dec 21, 2009

Appl. No.:

12/643790

Inventors:

Tri T. Dang - Winnetka CA, US
Brooks B. Cochran - Northridge CA, US
John J. Mastrototaro - Los Angeles CA, US
Rajiv Shah - Rancho Palos Verdes CA, US

Assignee:

MEDTRONIC MINIMED, INC. - Northridge CA

International Classification:

A61B 5/1473
G01N 27/26
C12Q 1/26
B05D 1/36

US Classification:

600347, 204415, 20440311, 204412, 427 212, 525128, 525127, 600345

Abstract:

Embodiments of the invention provide analyte sensors having elements designed to modulate their chemical reactions as well as methods for making and using such sensors. In certain embodiments of the invention, the sensor includes an analyte modulating membrane that comprises a blended mixture of a linear polyurethane/polyurea polymer, and a branched acrylate polymer.

US Patent:

20130178726, Jul 11, 2013

Filed:

Jan 5, 2012

Appl. No.:

13/344343

Inventors:

Brooks B. Cochran - Northridge CA, US
Tri T. Dang - Winnetka CA, US
Rajiv Shah - Rancho Palos Verdes CA, US

Assignee:

MEDTRONIC MINIMED, INC. - Northridge CA

International Classification:

A61B 5/1477
C08G 77/388
A61K 49/00

US Classification:

600347, 424 91, 525474

Abstract:

Embodiments of the invention provide analyte sensors having elements designed to modulate their chemical reactions as well as methods for making and using such sensors. In certain embodiments of the invention, the sensor includes an analyte modulating membrane that comprises a linear polyurethane/polyurea polymer comprising one or more agents selected for their ability to stabilize the polymers against thermal and/or oxidative degradation.