Bruce Thompson Violet Green

US Patent:

8568735, Oct 29, 2013

Filed:

Jun 22, 2010

Appl. No.:

13/379216

Inventors:

Annaliesa Anderson - Upper Saddle River NJ, US
Viliam Pavliak - Montebello NY, US
Kathrin Ute Jansen - Allendale NJ, US
Ingrid Lea Scully - Cornwall NY, US
Steven Morris Baker - Springwater NY, US
Jasdeep Singh Nanra - Suffern NY, US
Ellen Murphy - City Island NY, US
Bruce Arthur Green - New City NY, US
Mark Edward Ruppen - Garnerville NY, US
Yekaterina Timofeyeva - Mahwah NJ, US

Assignee:

Wyeth LLC - Madison NJ

International Classification:

A61K 39/085
A61K 39/40

US Classification:

42419711, 4241651, 4242431

Abstract:

The present invention relates to immunogenic compositions, comprising polypeptides and polysaccharides from. The present invention also relates to immunogenic compositions, comprising capsule polysaccharides conjugated to a carrier protein. In addition, the invention relates to methods of inducing an immune response in subjects against using immunogenic compositions of the polypeptides and capsule polysaccharides.

US Patent:

20120276137, Nov 1, 2012

Filed:

Jun 22, 2010

Appl. No.:

13/379291

Inventors:

Stephen John Freese - Cornwall-on-Hudson NY, US
Annaliesa Anderson - Upper Saddle River NJ, US
Viliam Pavliak - Montebello NY, US
Kathrin Ute Jansen - Allendale NJ, US
Ingrid Lea Scully - Cornwall NY, US
Tracy Dee Scott - Foristell MO, US
Jasdeep Singh Nanra - Suffern NY, US
A. Krishna Prasad - Chapel Hill NC, US
Bruce Arthur Green - New City NY, US

Assignee:

Wyeth LLC - Madison NJ

International Classification:

A61K 39/085
A61P 37/04
A61P 31/04
C07K 14/31

US Classification:

42419711, 530395

Abstract:

The present invention relates to immunogenic conjugates comprising serotype 5 and 8 capsular polysaccharides conjugated to carrier proteins and methods for their preparation and use. Methods for making the immunogenic conjugates of the invention involve covalent conjugation of the capsular polysaccharides with the carrier proteins using conjugation chemistry involving either 1,1-carboyl-di-1,2,4-triazole (CDT) or 3-(2-pyridyldithio)-propionyl hydrazide (PDPH).

US Patent:

20140017271, Jan 16, 2014

Filed:

Sep 20, 2013

Appl. No.:

14/032534

Inventors:

Viliam Pavliak - Montebello NY, US
Kathrin Ute Jansen - New York NY, US
Ingrid Lea Scully - Cornwall NY, US
Steven Morris Baker - Springwater NY, US
Jasdeep Singh Nanra - Suffern NY, US
Ellen Murphy - City Island NY, US
Bruce Arthur Green - New City NY, US
Mark Edward Ruppen - Garnerville NY, US
Yekaterina Timofeyeva - Pomona NY, US

Assignee:

Wyeth LLC - Madison NJ

International Classification:

A61K 39/085

US Classification:

4241901, 42419711

Abstract:

The present invention relates to immunogenic compositions, comprising polypeptides and polysaccharides from . The present invention also relates to immunogenic compositions, comprising capsule polysaccharides conjugated to a carrier protein. In addition, the invention relates to methods of inducing an immune response in subjects against using immunogenic compositions of the polypeptides and capsule polysaccharides.

US Patent:

42912822, Sep 22, 1981

Filed:

Sep 7, 1979

Appl. No.:

6/073441

Inventors:

Robert R. Alfano - New York NY
Bruce H. Green - Forest Hills NY

Assignee:

The Research Foundation of the City University of New York - New York NY

International Classification:

H01S 313

US Classification:

331 945S

Abstract:

A pulse producing mode-locked laser system with only passive lens and filtering elements and low cost Nd:glass laser material, or an equivalent, is stabilized and made to produce reliably output laser pulses of known characteristics and intensity without critical alignment and operating conditions. This is performed by eliminating response to spurious satellite laser pulses incited when triggering the coherent radiation in the laser materials. Several system components aid in the attainment of the better signal to noise ratio effective in making the laser system produce uniform output pulses from shot to shot, including provision of at least one mirror with a radius of curvature R meeting the criterion 3L>R>L where L is the path length through the laser material between two reflecting mirrors, and a dye mode-locking cell increased in path length by two orders of magnitude to the order of 1 cm. Also the mirrors have a wedge-shaped reflection surface at an angle of. gtoreq. 20' up to 2. degree.

US Patent:

20100221288, Sep 2, 2010

Filed:

May 12, 2010

Appl. No.:

12/778530

Inventors:

ROBERT JOHN ZAGURSKY - NEW YORK NY, US
AMY WADHAMS MASI - CALEDONIA NY, US
BRUCE ARTHUR GREEN - NEW CITY NY, US
DEB NARAYAN CHAKRAVARTI - CLAREMONT CA, US
DAVID PARRISH RUSSELL - CANANDAIGUA NY, US
JOSEPH LAWRENCE WOOTERS - BRIGHTON MA, US

Assignee:

WYETH HOLDINGS CORPORATION - MADISON NJ

International Classification:

A61K 39/02
C12P 21/06
C12N 9/00
C12N 1/21
C12N 15/63
C40B 40/08
C07H 21/04
C07H 21/02

US Classification:

4242341, 435 691, 435183, 4352523, 4353201, 506 17, 536 237, 536 243, 536 2433

Abstract:

The present invention relates to newly identified open reading frames comprised within the genomic nucleotide sequence of , wherein the open reading frames encode polypeptides that are surface localized on . Thus, the invention relates to open reading frames that encode polypeptide antigens, polypeptides, preferably antigenic polypeptides, encoded by the open reading frames, vectors comprising open reading frame sequences and cells or animals transformed with these vectors. The invention relates also to methods of detecting these nucleic acids or polypeptides and kits for diagnosing infection. The invention finally relates to pharmaceutical compositions, in particular immunogenic compositions, for the prevention and/or treatment of bacterial infection, in particular infections with . In particular embodiments, the immunogenic compositions are used for the treatment or prevention of systemic diseases which are induced or exacerbated by . In other embodiments, the immunogenic compositions are used for the treatment or prevention of non-systemic diseases, particularly of the otitis media, which are induced or exacerbated by

US Patent:

20160022798, Jan 28, 2016

Filed:

Jul 28, 2015

Appl. No.:

14/811017

Inventors:

- New York NY, US
Annaliesa Anderson - Upper Saddle River NJ, US
Viliam Pavliak - Montebello NY, US
Kathrin Ute Jansen - New York NY, US
Ingrid Lea Scully - Cornwall NY, US
Tracy Dee Scott - Foristell MO, US
Jasdeep Singh Nanra - Suffren NY, US
A. Krishna Prasad - Chapel Hill NC, US
Bruce Arthur Green - New City NY, US

International Classification:

A61K 39/085
C08B 37/00
A61K 47/48

Abstract:

The present invention relates to immunogenic conjugates comprising serotype 5 and 8 capsular polysaccharides conjugated to carrier proteins and methods for their preparation and use. Methods for making the immunogenic conjugates of the invention involve covalent conjugation of the capsular polysaccharides with the carrier proteins using conjugation chemistry involving either 1,1-carboyl-di-1,2,4-triazole (CDT) or 3-(2-pyridyldithio)-propionyl hydrazide (PDPH).

US Patent:

20150132336, May 14, 2015

Filed:

Oct 15, 2014

Appl. No.:

14/514625

Inventors:

- New York NY, US
Viliam Pavliak - Montebello NY, US
Kathrin Ute Jansen - New York NY, US
Ingrid Lea Scully - Cornwall NY, US
Steven Morris Baker - Springwater NY, US
Jasdeep Singh Nanra - Suffern NY, US
Ellen Murphy - City Island NY, US
Bruce Arthur Green - New City NY, US
Mark Edward Ruppen - Garnerville NY, US
Yekaterina Timofeyeva - Pomona NY, US

International Classification:

A61K 39/085

US Classification:

4241901

Abstract:

The present invention relates to immunogenic compositions, comprising polypeptides and polysaccharides from . The present invention also relates to immunogenic compositions, comprising capsule polysaccharides conjugated to a carrier protein. In addition, the invention relates to methods of inducing an immune response in subjects against using immunogenic compositions of the polypeptides and capsule polysaccharides.

Author:

Bruce A. Green

ISBN #:

0823213285

Author:

Bruce Green

ISBN #:

0895530716