Carl A Burtis

Author:

Carl A. Burtis

ISBN #:

0721601898

Author:

Carl A. Burtis

ISBN #:

0721637639

Author:

Carl A. Burtis

ISBN #:

0721638651

Author:

Carl A. Burtis

ISBN #:

0721644724

Author:

Carl A. Burtis

ISBN #:

0721656102

Author:

Carl A. Burtis

ISBN #:

0721686346

Author:

Carl A. Burtis

ISBN #:

3540407529

US Patent:

52428036, Sep 7, 1993

Filed:

May 5, 1992

Appl. No.:

7/878799

Inventors:

Carl A. Burtis - Oak Ridge TN
Wayne F. Johnson - Loudon TN
William A. Walker - Knoxville TN

Assignee:

Martin Marietta Energy Systems, Inc. - Oak Ridge TN

International Classification:

G01N 3353
G01N 33543

US Classification:

435 792

Abstract:

A rotor assembly for carrying out an assay includes a rotor body which is rotatable about an axis of rotation, and has a central chamber and first, second, third, fourth, fifth, and sixth chambers which are in communication with and radiate from the central chamber. The rotor assembly further includes a shuttle which is movable through the central chamber and insertable into any of the chambers, the shuttle including a reaction cup carrying an immobilized antigen or an antibody for transport among the chambers. A method for carrying out an assay using the rotor assembly includes moving the reaction cup among the six chambers by passing the cup through the central chamber between centrifugation steps in order to perform the steps of: separating plasma from blood cells, binding plasma antibody or antigen, washing, drying, binding enzyme conjugate, reacting with enzyme substrate and optically comparing the resulting reaction product with unreacted enzyme substrate solution. The movement of the reaction cup can be provided by attaching a magnet to the reaction cup and supplying a moving magnetic field to the rotor.

US Patent:

48472050, Jul 11, 1989

Filed:

Apr 8, 1987

Appl. No.:

7/036038

Inventors:

Carl A. Burtis - Oak Ridge TN
Wayne F. Johnson - Loudon TN

Assignee:

Martin Marietta Energy Systems, Inc. - Oak Ridge TN

International Classification:

B04B 502
B04B 1100
B01D 2126

US Classification:

436 45

Abstract:

A device and a method for automated processing and separation of an unmeasured sample of whole blood into multiple aliquots of plasma. Capillaries are radially oriented on a rotor, with the rotor defining a sample chamber, transfer channels, overflow chamber, overflow channel, vent channel, cell chambers, and processing chambers. A sample of whole blood is placed in the sample chamber, and when the rotor is rotated, the blood moves outward through the transfer channels to the processing chambers where the blood is centrifugally separated into a solid cellular component and a liquid plasma component. When the rotor speed is decreased, the plasma component backfills the capillaries resulting in uniform aliquots of plasma which may be used for subsequent analytical procedures.

US Patent:

48351067, May 30, 1989

Filed:

Jul 17, 1987

Appl. No.:

7/074739

Inventors:

Wayne F. Johnson - Loudon TN
Carl A. Burtis - Oak Ridge TN
William A. Walker - Knoxville TN

Assignee:

Martin Marietta Energy Systems, Inc. - Oak Ridge TN

International Classification:

G01N 110
G01N 2107

US Classification:

436 45

Abstract:

A rotor assembly for processing liquids, especially whole blood samples, is disclosed. The assembly includes apparatus for separating non-liquid components of whole blood samples from liquid components, apparatus for diluting the separated liquid component with a diluent and apparatus for transferring the diluted sample to an external apparatus for analysis. The rotor assembly employs several movable capillary tubes to handle the sample and diluents. A method for using the rotor assembly to process liquids is also described.

US Patent:

47404728, Apr 26, 1988

Filed:

Aug 5, 1985

Appl. No.:

6/762368

Inventors:

Carl A. Burtis - Oak Ridge TN
Wayne F. Johnson - Loudon TN
William A. Walker - Knoxville TN

Assignee:

The United States of America as represented by the United States
Department of Energy - Washington DC

International Classification:

B04B 502
B04B 1100
B01D 2126

US Classification:

436 63

Abstract:

A rotor and disc assembly for use in a centrifugal fast analyzer. The assembly is designed to process multiple samples of whole blood followed by aliquoting of the resultant serum into precisely measured samples for subsequent chemical analysis. The assembly requires minimal operator involvement with no mechanical pipetting. The system comprises (1) a whole blood sample disc, (2) a serum sample disc, (3) a sample preparation rotor, and (4) an analytical rotor. The blood sample disc and serum sample disc are designed with a plurality of precision bore capillary tubes arranged in a spoked array. Samples of blood are loaded into the blood sample disc in capillary tubes filled by capillary action and centrifugally discharged into cavities of the sample preparation rotor where separation of serum and solids is accomplished. The serum is loaded into the capillaries of the serum sample disc by capillary action and subsequently centrifugally expelled into cuvettes of the analytical rotor for analysis by conventional methods.

US Patent:

51732629, Dec 22, 1992

Filed:

May 30, 1989

Appl. No.:

7/359007

Inventors:

Carl A. Burtis - Oak Ridge TN
Wayne F. Johnson - Loudon TN
William A. Walker - Knoxville TN

Assignee:

Martin Marietta Energy Systems, Inc. - Oak Ridge TN

International Classification:

G01N 110
G01N 930
G01N 3500
B04B 502

US Classification:

422 72

Abstract:

A rotor assembly for performing a relatively large number of processing steps upon a sample, such as a whole blood sample, and a diluent, such as water, includes a rotor body for rotation about an axis and including a network of chambers within which various processing steps are performed upon the sample and diluent and passageways through which the sample and diluent are transferred. A transfer mechanism is movable through the rotor body by the influence of a magnetic field generated adjacent the transfer mechanism and movable along the rotor body, and the assembly utilizes centrifugal force, a transfer of momentum and capillary action to perform any of a number of processing steps such as separation, aliquoting, transference, washing, reagent addition and mixing of the sample and diluent within the rotor body. The rotor body is particularly suitable for automatic immunoassay analyses.