Carl A Samuelson

US Patent:

7504497, Mar 17, 2009

Filed:

Nov 9, 2006

Appl. No.:

11/595837

Inventors:

Paul S. Watson - Carrboro NC, US
Carl A. Samuelson - Durham NC, US
Christopher S. Crean - Pittsboro NC, US

Assignee:

Inspire Pharmaceuticals, Inc. - Durham NC

International Classification:

C07H 19/16
A01N 43/04
A61K 31/70

US Classification:

536 273, 514 46

Abstract:

This invention is directed to a method of preventing or treating diseases or conditions associated with platelet aggregation. The method is also directed to a method of treating thrombosis or related disorders. The method comprises administering to a subject a pharmaceutical composition comprising an effective amount of a non-nucleotide compound, preferably a P2Yreceptor antagonist compound, wherein said amount is effective to inhibit platelet aggregation. The compounds useful for this invention include compounds of general Formulae III, IIIa, and IIIb, or salts, hydrates, and solvates thereof. The present invention also provides novel compounds of Formulae IIIa and IIIb, which are potent and have a good oral bioavailability.

US Patent:

20100160250, Jun 24, 2010

Filed:

Dec 17, 2009

Appl. No.:

12/641208

Inventors:

Sammy R. Shaver - Chapel Hill NC, US
Tomas Navratil - Carrboro NC, US
José L. Boyer - Chapel Hill NC, US
Carl A. Samuelson - Durham NC, US
Jonathan B. DeCamp - Raleigh NC, US

International Classification:

A61K 31/70
C07H 19/167

US Classification:

514 46, 536 277

Abstract:

This invention provides a method for inhibiting the release of interleukin-1β in a mammal. This invention also provides a method for preventing or treating pulmonary diseases, ophthalmic diseases, and autoimmune diseases that are associated with inflammation or inflammatory conditions. The invention also provides a method for preventing or treating neurodegenerative diseases, or pain in a mammal. The method comprises administering to a mammal in need thereof a therapeutically effective amount of a mononucleoside compound, which is an antagonist of P2Xreceptor.