The present invention provides polynucleotides that can specifically hybridise to Hepatitis B virus (HBV) nucleic acids from all genotypes. These polynucleotides can be used in genotype-independent detection and quantitation of HBV nucleic acids. For example, the polynucleotides can be used as primers and/or probes in amplification-based assays for either end-point detection or real-time monitoring of HBV nucleic acids in a test sample. The polynucleotides can additionally be provided as part of a kit for the detection and quantitation of HBV nucleic acids.
Jeffrey B. Huff - Park Ridge IL Barbara T. Merchant - Wilmette IL Carolyn R. Mullen - Libertyville IL Seshagiri R. Tata Venkata - Chicago IL
Assignee:
Abbott Laboratories - Abbott Park IL
International Classification:
C07H 1704 C07D31102
US Classification:
536 41
Abstract:
Fluorescent enzyme substrates are provided. The substrates are derivatives of coumarin having an enzyme cleavable group at position 7 and a hydrophilic amide group at position 4. The compounds are highly water soluble, stable at ambient and reduced temperatures and fluoresce upon cleavage by an enzyme.
Nucleic Acid Primers And Probes For Detecting Mycoplasma Pneumoniae
Carolyn R. Mullen - Libertyville IL Joann C. Sustachek - Racine WI
Assignee:
Abbott Laboratories - Abbott Park IL
International Classification:
C07H 2104 C12Q 168 C12P 1934
US Classification:
435 6
Abstract:
Nucleic acid sequences that are useful for detecting Mycoplasma pneumoniae are herein provided. These sequences can be used in hybridization assays or amplification based assays designed to detect the presence of Mycoplasma pneumoniae in a test sample. Additionally, the sequences can be provided as part of a kit.
- DES PLAINES IL, US Kevin S. Nelson - Des Plaines IL, US Shihai Huang - Des Plaines IL, US Rupinder Kular - Des Plaines IL, US Carolyn Mullen - Des Plaines IL, US James Rhoads - Des Plaines IL, US
International Classification:
C12Q 1/6886
Abstract:
Provided herein is technology relating to detecting molecular markers relevant to cancer and particularly, but not exclusively, to methods and compositions for quantifying and/or detecting EGFR mRNA and/or EGFRvIII mRNA in biological samples.
- Des Plaines IL, US Kevin S. Nelson - Des Plaines IL, US Shihai Huang - Des Plaines IL, US Rupinder Kular - Des Plaines IL, US Carolyn Mullen - Des Plaines IL, US James Rhoads - Des Plaines IL, US
International Classification:
C12Q 1/68
Abstract:
Provided herein is technology relating to detecting molecular markers relevant to cancer and particularly, but not exclusively, to methods and compositions for quantifying and/or detecting EGFR mRNA and/or EGFRvIII mRNA in biological samples.