Caryn Y Ito from 127 Anela St, Hilo, HI 96720, age 60, Phone: 8089597274

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Localization And Characterization Of The Wilms' Tumor Gene
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US Patent:

20020082394, Jun 27, 2002
Filed:

Aug 14, 2001
Appl. No.:

09/929315
Inventors:

Katherine Call - Malden MA, US
Thomas Glaser - Belmont MA, US
Caryn Ito - Chapel Hill NC, US
Alan Buckler - Cambridge MA, US
Jerry Pelletier - Montreal, CA
Daniel Haber - Cambridge MA, US
Elise Rose - Oakland CA, US
David Housman - Newton MA, US
Wendy Bruening - Montreal, CA
Andre Darveau - St. Foy, CA
Assignee:

Massachusetts Institute of Technology - Cambridge MA
International Classification:

A61K039/395
C12N015/74
C07K016/30
US Classification:

530/387700, 424/155100, 435/320100
Abstract:

The Wilms' tumor gene associated with 11p3 locus on the human chromosome, as well as a method of analyzing cells for the gene is described and characterized. The gene encodes a transcription unit approximately 50 kb in size and a mRNA of approximately 3 kb, which is expressed in predominantly in kidney and gonadal tissue. The gene is alternative spliced producing four very similar mRNA transcripts. The polypeptides encoded by the Wilms' tumor DNA includes four “zinc fingers” and a region rich in proline and glutamine, suggesting that the polypeptide has a role in transcription regulation.

Localization And Characterization Of The Wilms' Tumor Gene
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US Patent:

20020128196, Sep 12, 2002
Filed:

Nov 12, 2001
Appl. No.:

09/993215
Inventors:

Katherine Call - Malden MA, US
Thomas Glaser - Belmont MA, US
Caryn Ito - Chapel Hill NC, US
Alan Buckler - Cambridge MA, US
Jerry Pelletier - Montreal, CA
Daniel Haber - Cambridge MA, US
Elise Rose - Oakland CA, US
David Housman - Newton MA, US
Wendy Bruening - Montreal, CA
Andre Darveau - St. Foy, CA
Assignee:

Massachusetts Institute of Technology - Cambridge MA
International Classification:

A61K039/00
A61K038/17
US Classification:

514/012000, 424/185100
Abstract:

The Wilms' tumor gene associated with 11p3 locus on the human chromosome, as well as a method of analyzing cells for the gene is described and characterized. The gene encodes a transcription unit approximately 50 kb in size and a mRNA of approximately 3 kb, which is expressed in predominantly in kidney and gonadal tissue. The gene is alternative spliced producing four very similar mRNA transcripts. The polypeptides encoded by the Wilms' tumor DNA includes four “zinc fingers” and a region rich in proline and glutamine, suggesting that the polypeptide has a role in transcription regulation.

Localization And Characterization Of The Wilms' Tumor Gene
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US Patent:

63165996, Nov 13, 2001
Filed:

Mar 9, 1998
Appl. No.:

9/037179
Inventors:

Katherine M. Call - Malden MA
Thomas M. Glaser - Cambridge MA
Caryn Y. Ito - Chapel Hill NC
Alan J. Buckler - Brookline MA
Jerry Pelletier - St. Leonard, CA
Daniel A. Haber - Cambridge MA
Elise A. Rose - Oakland CA
David E. Housman - Newton MA
Wendy Breuning - Montreal, CA
Andre Darveau - St. Foy, CA
Assignee:

Massachusetts Institute of Technology - Cambridge MA
International Classification:

C07K 1600
C12P 2108
US Classification:

5303877
Abstract:

The Wilms' tumor gene associated with 11p3 locus on the human chromosome, as well as a method of analyzing cells for the gene is described and characterized. The gene encodes a transcription unit approximately 50 kb in size and a mRNA of approximately 3 kb, which is expressed in predominantly in kidney and gonadal tissue. The gene is alternative spliced producing four very similar mRNA transcripts. The polypeptides encoded by the Wilms' tumor DNA includes four "zinc fingers" and a region rich in proline and glutamine, suggesting that the polypeptide has a role in transcription regulation.

Localization And Characterization Of The Wilms' Tumor Gene
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US Patent:

57262888, Mar 10, 1998
Filed:

Aug 2, 1993
Appl. No.:

8/102942
Inventors:

Katherine M. Call - Malden MA
Thomas M. Glaser - Belmont MA
Caryn Y. Ito - Chapel Hill NC
Alan J. Buckler - Cambridge MA
Jerry Pelletier - Montreal, CA
Daniel A. Haber - Cambridge MA
Elise A. Rose - Oakland CA
David E. Housman - Newton MA
Wendy Bruening - Montreal, CA
Andre Darveau - St. Foy, CA
Assignee:

Massachusetts Institute of Technology - Cambridge MA
International Classification:

C07K 14435
US Classification:

530350
Abstract:

The Wilms' tumor gene associated with 11p3 locus on the human chromosome, as well as a method of analyzing cells for the gene is described and characterized. The gene encodes a transcription unit approximately 50 kb in size and a mRNA of approximately 3 kb, which is expressed in predominantly in kidney and gonadal tissue. The gene is alternative spliced producing four very similar mRNA transcripts. The polypeptides encoded by the Wilms' tumor DNA includes four "zinc fingers" and a region rich in proline and glutamine, suggesting that the polypeptide has a role in transcription regulation.

Caryn Y Ito