Perkinelmer, Inc.
Director of Mass Spectrometry Applications
Bruker Daltonics Sep 1993 - Jan 2009
Director of Applications
Waters Corporation 1983 - 1993
Product Manager
Education:
The University of Manchester 1979 - 1982
Doctorates, Doctor of Philosophy, Chemistry
Skills:
Analytical Chemistry Biochemistry Bioinformatics Chromatography Chemistry Hplc Instrumentation Lc Ms Laboratory Automation Life Sciences Maldi Tof Mass Spectrometry Product Development Product Launch Protein Chemistry Proteomics R Training Biomarkers Strategic Planning Genomics Lifesciences Biotechnology Start Ups Management R&D
Method And Apparatus For Continuous Sample Deposition On Sample Support Plates For Liquid Chromatography-Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry
Disclosed is a method and apparatus for matrix-assisted laser desorption ionization (MALDI), whereby the components of a sample separated by the column of a chromatographic separation device such as a liquid chromatograph or capillary electrophoresis are eluted and deposited on a sample support plate in a continuous track which both concentrates the sample components and preserves the fidelity of the separation. Analysis by MALDI is thus decoupled from the requirements of the separation and deposition and is performed by moving the continuous track relative to a focused laser beam in order to ionize the sample. The deposition capillary is in relative motion to the sample support plate with a speed of motion compatible with the liquid flow rate. In order to prevent the liquid sample from spreading across the sample support plate and to focus it to a pre-defined narrow region, the deposition of the sample is made along a hydrophilic anchor track of a well-defined width of less than 1 mm on the surface of the sample plate.
Melvin Park - Billerica MA, US Taeman Kim - Westford MA, US Catherine Stacey - Boxborough MA, US Christian Berg - Roslindale MA, US
International Classification:
H01J 49/00
US Classification:
250287000, 25042300P
Abstract:
Disclosed is an improved method and apparatus for transporting ions from a first pressure region in a mass spectrometer to a second pressure region therein. More specifically, the present invention provides a segmented ion funnel for more efficient use in mass spectrometry (particularly with ionization sources) to transport ions from the first pressure region to the second pressure region.