Chad E Hagedorn

US Patent:

20060216801, Sep 28, 2006

Filed:

Mar 17, 2004

Appl. No.:

10/550556

Inventors:

Harald Groger - Hanau, DE
Claudia Rollmann - Alzenau, DE
Hendrik Husken - Haltern am See, DE
Helge Werner - Bruchkobel, DE
Francoise Chamouleau - Hanau, DE
Chad Hagedorn - Bellbrook OH, US
Karlheinz Drauz - Freidericht, DE
Werner Hummel - Titz, DE

Assignee:

Degussa AG - Dusseldorf

International Classification:

C12P 7/40

US Classification:

435136000

Abstract:

The present application relates to a reaction system in which chemically valuable compounds can be obtained in high enantiomer concentrations with the aid of a coupled enzymatically operating transformation process. The coupled enzymatic reaction system comprises a cofactor-dependent enzymatic transformation of an organic compound and an enzymatic regeneration of the cofactor, wherein the reaction system operates in aqueous solution with an amount of substrate above the solubility limit thereof. In the preferred embodiments, an alcohol dehydrogenase is the cofactor-dependent enzyme, and the regeneration of the cofactor (e.g. NADH or NADPH) is acheved by means of formate dehydrogenase.

US Patent:

20080145904, Jun 19, 2008

Filed:

Aug 4, 2005

Appl. No.:

11/659291

Inventors:

Harald Groger - Erlangen, DE
Francoise Chamouleau - Hanau, DE
Chad Hagedorn - Bellbrook OH, US

International Classification:

C12P 7/04

US Classification:

435157

Abstract:

The present invention relates to a process for the production of primary alcohols from aldehydes with the said of whole-cell catalysts or isolated enzymes. Employed are an alcohol dehydrogenase and an enzyme which is capable of regenerating the cofactor, where it is preferred to have a substrate concentration of >150 mM aldehyde for the conversion.