Charles J Guinosso from Carlsbad, CA, age 82

Compositions And Methods For Modulating Rna
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US Patent:

6358931, Mar 19, 2002
Filed:

Aug 30, 1994
Appl. No.:

08/295744
Inventors:

Phillip Dan Cook - Carlsbad CA
Thomas Bruice - Carlsbad CA
Charles John Guinosso - Vista CA
Andrew Mamoru Kawasaki - Oceanside CA
Richard Griffey - San Marcos CA
Assignee:

ISIS Pharmaceuticals, Inc. - Carlsbad CA
International Classification:

C07H 2107
US Classification:

514 44, 536221, 536 231, 536 245
Abstract:

Compositions and methods for modulating the activity of RNA are disclosed, In accordance with preferred embodiments, antisense compositions are prepared targeting reactive portions. The reactive portions preferably comprise one or two imidazole functionalities conjugated to the targeting oligonucleotide via linkers with or without intervening intercalating moieties. Therapeutics, diagnostics and research methods also are disclosed, as are synthetic nucleosides and nucleoside fragments that can be elaborated into oligonucleotides.

Compositions And Methods For Modulating Rna
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US Patent:

6610663, Aug 26, 2003
Filed:

Oct 10, 2001
Appl. No.:

09/974326
Inventors:

Phillip Dan Cook - Carlsbad CA
Thomas Bruice - Carlsbad CA
Charles John Guinosso - Vista CA
Andrew Mamoru Kawasaki - Oceanside CA
Richard Griffey - San Marcos CA
Assignee:

ISIS Pharmaceuticals, Inc. - Carlsbad CA
International Classification:

A61K 4800
US Classification:

514 44, 536 231, 536 245, 536221, 435 6
Abstract:

Compositions and methods for modulating the activity of RNA are disclosed. In accordance with preferred embodiments, antisense compositions are prepared comprising targeting and reactive portions. The reactive portions preferably comprise one or two imidazole functionalities conjugated to the targeting oligonucleotide via linkers with or without intervening intercalating moieties. Therapeutics, diagnostics and research methods also are disclosed, as are synthetic nucleosides and nucleoside fragments that can be elaborated into oligonucleotides.

Modified Oligonucleotides
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US Patent:

6653458, Nov 25, 2003
Filed:

Nov 8, 1999
Appl. No.:

09/435806
Inventors:

Muthiah Manoharan - Carlsbad CA
Phillip Dan Cook - Fallbrook CA
Charles J. Guinosso - Vista CA
Assignee:

ISIS Pharmaceuticals, Inc. - Carlsbad CA
International Classification:

C07H 1900
US Classification:

536 231, 536 221, 536 253, 536 2531, 536 2532, 536 2533, 536 2534
Abstract:

Modified oligonucleotides containing at least one 2â,5â-internucleotide linkage are provided. The oligonucleotides of the invention may also bear additional substituents at the 2â- and 3â-positions.

Amine-Derivatized Nucleosides And Oligonucleosides
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US Patent:

6783931, Aug 31, 2004
Filed:

Sep 3, 1993
Appl. No.:

08/117363
Inventors:

Phillip Dan Cook - Carlsbad CA
Muthiah Manoharan - Carlsbad CA
Charles J. Guinosso - Vista CA
Assignee:

ISIS Pharmaceuticals, Inc. - Carlsbad CA
International Classification:

C12Q 168
US Classification:

435 6, 435 71, 435 911, 435 912, 536 221, 536 231, 536 243, 536 2431, 536 2432, 536 2433, 536 245, 536 2532
Abstract:

Nucleosides and oligonucleosides functionalized to include alkylamino functionality, and derivatives thereof. In certain embodiments, the compounds of the invention further include steriods, reporter molecules, reporter enzymes, lipophilic molecules, peptides or proteins attached to the nucleosided through the alkylamino group.

Amine-Derivatized Nucleosides And Oligonucleosides
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US Patent:

6900297, May 31, 2005
Filed:

Jun 5, 1995
Appl. No.:

08/464953
Inventors:

Phillip Dan Cook - Carlsbad CA, US
Muthiah Manoharan - Carlsbad CA, US
Charles J. Guinosso - Vista CA, US
Assignee:

ISIS Pharmaceuticals, Inc. - Carlsbad CA
International Classification:

C07H021/02
C12Q001/68
US Classification:

536 221, 536 231, 536 243, 435 6
Abstract:

Nucleotides and oligonucleosides functionalized to include alkylamino functionality, and derivatives thereof. In certain embodiments, the compounds of the invention further include steroids, reporter molecules, reporter enzymes, lipophilic molecules, peptides or proteins attached to the nucleotides through the alkylamino group.

Amine-Derivatized Nucleosides And Oligonucleosides
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US Patent:

7037646, May 2, 2006
Filed:

Sep 2, 1994
Appl. No.:

08/602862
Inventors:

Phillip Dan Cook - Vista CA, US
Muthiah Manoharan - Carlsbad CA, US
Charles J. Guinosso - Vista CA, US
Assignee:

ISIS Pharmaceuticals, Inc. - Carlsbad CA
International Classification:

C12Q 1/68
C07H 21/00
C07H 21/02
C07H 21/04
US Classification:

435 6, 514 44, 536 231, 536 245
Abstract:

Nucleosides and oligonucleosides functionalized to include alkylamino functionality, and derivatives thereof. In certain embodiments, the compounds of the invention further include steroids, reporter molecules, reporter enzymes, lipophilic molecules, peptides or proteins attached to the nucleosides through the alkylamino group.

Cycloalkyfused Indole, Benzothiophene, Benzofuran And Idene Derivatives
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US Patent:

7297704, Nov 20, 2007
Filed:

Feb 16, 2006
Appl. No.:

11/355452
Inventors:

Annmarie Louise Sabb - Pennington NJ, US
Robert Lewis Vogel - Collingswood NJ, US
Gary Paul Stack - Ambler PA, US
Deborah Ann Evrard - Hamilton Square NJ, US
Amedeo Arturo Failli - Princeton Junction NJ, US
Lalitha Krishnan - Airmont NY, US
Anita Wai-Yin Chan - Fort Lee NJ, US
Jianxin Ren - Nanuet NY, US
Charles J. Guinosso - Chestnut Ridge NY, US
Reinhardt Bernhard Baudy - Hellertown PA, US
Jean Yi-ching Sze - Monmouth Junction NJ, US
Yanfang Li - Lawrenceville NJ, US
Antonia Nikitenko - Tarrytown NY, US
Assignee:

Wyeth - Madison NJ
International Classification:

C07D 209/48
C07D 207/40
C07D 207/444
US Classification:

514291, 546 90, 548438
Abstract:

The present invention provides cycloalkylfused indole, benzothiophene, benzofuran, and indene derivatives, and methods for using them to, for example, treat, prevent and/or ameliorate central nervous system diseases by antagonizing 5-HTreceptors and modulating serotonin levels.

Process For The Synthesis C-2, C-3 Substituted N-Alkylated Indoles Useful As Cplainhibitors
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US Patent:

7582772, Sep 1, 2009
Filed:

Aug 18, 2005
Appl. No.:

11/207072
Inventors:

Ronald S. Michalak - Congers NY, US
Mahmut Levent - Bloomfield NJ, US
Frederick J. Vyverberg - Chester NY, US
Ara R. Boyajian - River Vale NJ, US
Panolil Raveendranath - Monroe NY, US
Michel Cantin - Saint-Laurent, CA
Alan Stockton - Longueuil, CA
Michael W. Winkley - Campbell Hall NY, US
Mousumi Ghosh - Elmwood Park NJ, US
Christoph Dehnhardt - New York NY, US
Charles Guinosso - Chestnut Ridge NY, US
Assignee:

Wyeth - Madison NJ
International Classification:

C07D 209/04
C07C 255/58
US Classification:

548504, 564 99
Abstract:

The present invention provides method for making a compound of formula 1:.

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Charles J Guinosso