Christopher J Sloey

US Patent:

8314063, Nov 20, 2012

Filed:

Jul 1, 2010

Appl. No.:

12/829325

Inventors:

Tiansheng Li - Newbury Park CA, US
Christopher J. Sloey - Newbury Park CA, US

Assignee:

Amgen Inc. - Thousand Oaks CA

International Classification:

A61K 38/18
C07K 14/505

US Classification:

514 77, 530399

Abstract:

A method of stabilizing an aqueous protein or antibody formulation is disclosed herein. Additionally, stable pharmaceutical formulations are contemplated which comprise a biologically active protein, a destabilizing concentration of preservative and a stabilizing concentration of osmolyte.

US Patent:

8383114, Feb 26, 2013

Filed:

Sep 29, 2008

Appl. No.:

12/680128

Inventors:

Christopher J. Sloey - Newbury Park CA, US
Camille Vergara - Calabasas CA, US
Jason Ko - Thousand Oaks CA, US
Tiansheng Li - Newbury Park CA, US

Assignee:

Amgen Inc. - Thousand Oaks CA

International Classification:

C07K 14/00

US Classification:

4241341, 514 12, 530350

Abstract:

A stable pharmaceutical formulation is provided that comprises a biologically active protein and an excipient selected from carnitine, creatine or creatinine.

US Patent:

20030104996, Jun 5, 2003

Filed:

Aug 30, 2001

Appl. No.:

09/945517

Inventors:

Tiansheng Li - Thousand Oaks CA, US
Byeong Chang - Thousand Oaks CA, US
Christopher Sloey - Sherman Oaks CA, US

International Classification:

A61K038/22

US Classification:

514/012000

Abstract:

The present invention relates to single use and multi-dose pharmaceutical formulations comprising a biologically active agent and methionine, wherein said formulations demonstrate improved stability, and wherein said formulations do not contain human serum albumin.

US Patent:

20070053871, Mar 8, 2007

Filed:

Aug 4, 2006

Appl. No.:

11/499607

Inventors:

Tiansheng Li - Newbury Park CA, US
Christopher Sloey - Newbury Park CA, US

Assignee:

AMGEN INC. - Thousand Oaks CA

International Classification:

A61K 38/19
A61K 38/18

US Classification:

424085100, 514012000

Abstract:

A method of stabilizing an aqueous protein or antibody formulation is disclosed herein. Additionally, stable pharmaceutical formulations are contemplated which comprise a biologically active protein, a destabilizing concentration of preservative and a stabilizing concentration of osmolyte.

US Patent:

20100297117, Nov 25, 2010

Filed:

Nov 13, 2008

Appl. No.:

12/743333

Inventors:

Christopher James Sloey - Newbury Park CA, US
Jason Ko - Thousand Oaks CA, US
Tiansheng Li - Newbury Park CA, US

Assignee:

AMGEN INC. - Thousand Oaks CA

International Classification:

A61K 39/395
A61K 38/18
A61P 7/00

US Classification:

4241331, 514 77, 4241301, 4241581, 4241451

Abstract:

The present invention relates to stable aqueous protein formulations. In particular, disclosed herein are therapeutic protein formulations suitable for parenteral administration having one or more antioxidants.

US Patent:

20130071387, Mar 21, 2013

Filed:

Nov 15, 2012

Appl. No.:

13/678407

Inventors:

AMGEN INC. - Thousand Oaks CA, US
Christopher James Sloey - Newbury Park CA, US

Assignee:

AMGEN INC. - Thousand Oaks CA

International Classification:

A61K 47/10

US Classification:

4241331, 4241721

Abstract:

A method of stabilizing an aqueous protein or antibody formulation is disclosed herein. Additionally, stable pharmaceutical formulations are contemplated which comprise a biologically active protein, a destabilizing concentration of preservative and a stabilizing concentration of osmolyte.

US Patent:

20130171128, Jul 4, 2013

Filed:

Mar 1, 2011

Appl. No.:

13/582357

Inventors:

Holly Zhuohong Huang - Thousand Oaks CA, US
Dingjiang Liu - Oak Park CA, US
Christopher J. Sloey - Newbury Park CA, US
Camille Gleason - Santa Monica CA, US

Assignee:

AMGEN INC. - Thousand Oaks CA

International Classification:

A61K 47/18
A61K 47/20

US Classification:

4241301, 514 11

Abstract:

A stable pharmaceutical formulation is provided that comprises a biologically active protein and an excipient selected from taurine, theanine, sarcosine, citrulline and betaine.

US Patent:

20220226477, Jul 21, 2022

Filed:

Apr 22, 2020

Appl. No.:

17/605512

Inventors:

- Thousand Oaks CA, US
Christopher James SLOEY - Newbury Park CA, US

International Classification:

A61K 47/32
A61K 9/00
A61K 9/19

Abstract:

Disclosed herein are pharmaceutical compositions (formulations) having reduced viscosity, using a low molecular weight polyvinylpyrrolidone (povidone) in the case of high therapeutic protein concentration (≥70 mg/ml) formulations. The addition of arginine, such as arginine monohydrochloride or N-acetyl arginine, can further reduce viscosity. Appropriate therapeutic proteins include antibodies, such as monoclonal antibodies, and derivatives, fragments, and analogues thereof.