Christopher R Vakoc from Cold Spring Harbor, NY, age 45

Compositions And Methods For Treating Leukemia
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US Patent:

20140011862, Jan 9, 2014
Filed:

Jul 3, 2013
Appl. No.:

13/934843
Inventors:

Junwei Shi - Cold Spring Harbor NY, US
Christopher R. Vakoc - Cold Spring Harbor NY, US
Assignee:

Cold Spring Harbor Laboratory - Cold Spring Harbor NY
Dana-Farber Cancer Institute, Inc. - Boston MA
International Classification:

C07D 495/14
C12Q 1/68
C12N 15/113
US Classification:

514 44 A, 435375, 435377, 506 9, 435 612, 514220
Abstract:

The invention provides compositions, methods, and kits for the treatment of acute myeloid leukemia in a subject.

Identification Of Rnai Targets And Use Of Rnai For Rational Therapy Of Chemotherapy-Resistant Leukemia And Other Cancers
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US Patent:

20120272346, Oct 25, 2012
Filed:

Mar 29, 2010
Appl. No.:

13/260540
Inventors:

Bruce Stillman - Cold Spring Harbor NY, US
Scott W. Lowe - Cold Spring Harbor NY, US
Anthony Mazurek - Cold Spring Harbor NY, US
Johannes Ekkehart Zuber - Cold Spring Harbor NY, US
Christopher Vakoc - Oyster Bay NY, US
Katherine McJunkin - Cold Spring Harbor NY, US
International Classification:

A61K 31/7088
A61K 49/00
A61P 35/02
A01K 67/027
US Classification:

800 10, 424 92, 514 44 A
Abstract:

Provided is a mosaic mouse model for use in determining the potency of an shRNA in vivo for reducing survival of cancer cells of chemotherapy-resistant leukemia. The syngeneic mouse recipient is transplanted with tet-on competent leukemia cells carrying a bicistronic nucleic acid construct comprising a promoter operably linked to a fusion gene associated with chemotherapy-resistant leukemia, and a sequence encoding a reverse tet-transactivator protein, such that both coding sequences are co-expressed from the promoter. Also provided are methods of treating soft tissue cancers.

Compositions And Methods For Hemoglobin Production
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US Patent:

20190365734, Dec 5, 2019
Filed:

Jan 30, 2018
Appl. No.:

16/478651
Inventors:

- Philadelphia PA, US
- Cold Spring Harbor NY, US
Christopher Vakoc - Cold Spring Harbor NY, US
International Classification:

A61K 31/454
A61P 7/06
A61K 31/517
Abstract:

Methods and compositions for producing fetal hemoglobin and treating a hemoglobinopathy or thalassemia are disclosed.

Compositions And Methods For Treating Leukemia
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US Patent:

20180222917, Aug 9, 2018
Filed:

Oct 17, 2017
Appl. No.:

15/786249
Inventors:

- Boston MA, US
- Cold Spring Harbor NY, US
Junwei Shi - Cold Spring Harbor NY, US
Christopher R. Vakoc - Cold Spring Harbor NY, US
Scott W. Lowe - New York NY, US
Constantine S. Mitsiades - Boston MA, US
International Classification:

C07D 495/14
C12Q 1/6886
A61K 31/5517
C12N 15/11
C12N 15/113
Abstract:

The invention provides compositions, methods, and kits for the treatment of acute myeloid leukemia in a subject.

Identification Of Rnai Targets And Use Of Rnai For Rational Therapy Of Chemotherapy-Resistant Leukemia And Other Cancers
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US Patent:

20150283101, Oct 8, 2015
Filed:

Nov 3, 2014
Appl. No.:

14/531669
Inventors:

- COLD SPRING HARBOR NY, US
Scott W. LOWE - Cold Spring Harbor NY, US
Anthony MAZUREK - Cold Spring Harbor NY, US
Johannes Ekkehart ZUBER - Cold Spring Harbor NY, US
Christopher VAKOC - Oyster Bay NY, US
Katherine MCJUNKIN - Cold Spring Harbor NY, US
International Classification:

A61K 31/185
Abstract:

Provided is a mosaic mouse model for use in determining the potency of an shRNA in vivo for reducing survival of cancer cells of chemotherapy-resistant leukemia. The syngeneic mouse recipient is transplanted with tet-on competent leukemia cells carrying a bicistronic nucleic acid construct comprising a promoter operably linked to a fusion gene associated with chemotherapy-resistant leukemia, and a sequence encoding a reverse tet-transactivator protein, such that both coding sequences are co-expressed from the promoter. Also provided are methods of treating soft tissue cancers.

Christopher R Vakoc