Christopher S Youngen

US Patent:

53915801, Feb 21, 1995

Filed:

May 10, 1993

Appl. No.:

8/059558

Inventors:

Mary B. Douglas - Holland OH
Don N. Gray - Sylvania OH
Barry Watson - Toledo OH
Christopher S. Youngen - Toledo OH

Assignee:

Anatrace Inc. - Maumee OH

International Classification:

C08G 7522
C08J 520
A61M 114

US Classification:

521 27

Abstract:

A biocompatable multi-layer article suitable for use in blood oxygenation is disclosed. The article is made up of a microporous polypropylene tube, a perm-selective, water vapor impermeable, carbon dioxide and oxygen permeable, homogeneous layer directly adhered to the polypropylene tube and active heparin linked through a covalent bond to the permselective layer. The polypropylene tube has an inside diameter from 240 to 400. mu. m, a wall thickness from 10 to 50. mu. m, and a porosity from 20 to 80 percent. The perm-selective layer is a polysulfone which has the structure ##STR1## where R is an alkyl group having 16 carbon atoms and n is 3,500 to 35,000. A method for producing a biocompatible multi-layer article suitable for use in blood oxygenation is also disclosed. The method involves the steps of immersing a microporous polypropylene tube which has an inside diameter from 240 to 400. mu. m, a wall thickness from 10 to 50. mu.