Chulmin Joo

US Patent:

8314399, Nov 20, 2012

Filed:

May 17, 2010

Appl. No.:

12/781206

Inventors:

Brent Allen Clothier - Clifton Park NY, US
Adrian Ivan - Niskayuna NY, US
Chulmin Joo - Niskayuna NY, US
Daniel Bruno McDevitt - Galway NY, US

Assignee:

General Electric Company - Niskayuna NY

International Classification:

G01T 3/00

US Classification:

25039001

Abstract:

A radiation detector includes a neutron sensing element comprising a neutron scintillating composite material that emits a first photon having a first wavelength and an optical waveguide material having a wavelength-shifting dopant dispersed therein that absorbs the first photon emitted by the neutron scintillating composite material and emits a second photon having a second, different wavelength, and a functionalized reflective layer at an interface between the neutron scintillating composite material and the optical waveguide material. The functionalized reflective layer allows the first photon emitted by the neutron scintillating composite material to pass through and into the optical waveguide material, but prevents the second photon emitted by the optical waveguide material from passing through and into the neutron scintillating composite material. The photons emitted from the neutron sensing element are collected and channeled through the optical waveguide material and into a photosensing element optically coupled to the neutron sensing element.

US Patent:

20070009935, Jan 11, 2007

Filed:

May 15, 2006

Appl. No.:

11/435228

Inventors:

Chulmin Joo - Cambridge MA, US
Johannes De Boer - Somerville MA, US

International Classification:

C12Q 1/68
C12M 3/00

US Classification:

435006000, 435287200

Abstract:

Systems, arrangements and methods for a molecular recognition are provided. For example, a particular radiation having wavelength that varies over time and/or a spectral width that is greater than 10 nm can be provided. For example, at least one first electro-magnetic radiation can be provided to at least one sample, and at least one second electro-magnetic radiation may be provided to a reference, with both the first and second electro-magnetic radiations being part of the particular radiation. Further, the interference between a third electro-magnetic radiation (associated with the first electro-magnetic radiation) and a fourth electro-magnetic radiation (associated with the second electro-magnetic radiation) can be detected. A change in a thickness of at least one portion of the sample based on the interference can be determined.

US Patent:

20090219544, Sep 3, 2009

Filed:

Sep 5, 2008

Appl. No.:

12/205277

Inventors:

Chulmin Joo - Schenectady NY, US
Johannes F. De Boer - Amstelveen, NL

Assignee:

The General Hospital Corporation - Boston MA

International Classification:

G01J 3/45
G01B 9/02

US Classification:

356456, 356451

Abstract:

Exemplary arrangement, apparatus, method and computer accessible can be provided. For example, using the exemplary arrangement, apparatus and method, it is possible to configured to propagate at least one electro-magnetic radiation. Indeed, it is possible to receive, using at least one first arrangement, a first portion of the at least one electro-magnetic radiation directed to a sample and a second portion of the least one electro-magnetic radiation directed to a reference, the first arrangement can be structured to at least partially reflect and at least partially allow to transmit the first and second portions. In addition, it is possible to receive, using a second arrangement, (i) a third portion of the electro-magnetic radiation associated with at least one of the transmitted first portion or the reflected first portion from the sample and (ii) a fourth portion of the electro-magnetic radiation associated with at least one of the second transmitted portion of the least one electro-magnetic radiation or the reflected second portion from the reference. The third and fourth portions can travel at least partially along substantially the same path toward the second arrangement, Further, the second arrangement can be configured to receive the reflected first and second portion(s) which interfere with one another, and generate at least one signal which includes information associated with at least one fluctuation in an uncommon path of the first and second portions prior to a receipt thereof by the at least one first arrangement. In addition or alternatively, the second arrangement can be configured to determine information regarding a spectrally resolved interference associated with the third and fourth portions.

US Patent:

20110122412, May 26, 2011

Filed:

Nov 23, 2009

Appl. No.:

12/623714

Inventors:

Chulmin Joo - Niskayuna NY, US
Anthony John Murray - Lebanon NJ, US
Masako Yamada - Niskayuna NY, US

Assignee:

GENERAL ELECTRIC COMPANY - SCHENECTADY NY

International Classification:

G01J 3/45

US Classification:

356451

Abstract:

An optical detection system for sensing one or more samples is provided. The optical detection system comprises a broadband light source that emits a beam comprising a continuous spectrum over a range of wavelengths; a fluidic cell comprising one or more channels that positions the sample so that at least a portion of the beam is directed on the sample to produce a back reflected beam; and a spectrometer that analyzes an interference spectrum of the beam back reflected from the sample.

US Patent:

20130052725, Feb 28, 2013

Filed:

Oct 31, 2011

Appl. No.:

13/285976

Inventors:

Siavash Yazdanfar - Niskayuna NY, US
Vasile Bogdan Neculaes - Niskayuna NY, US
Kenneth Roger Conway - Clifton Park NY, US
Allen Lawrence Garner - Clifton Park NY, US
Evelina Roxana Loghin - Rexford NY, US
Dmitry Vladimirovich Dylov - Schenectady NY, US
Brian Michael Davis - Albany NY, US
Chulmin Joo - Niskayuna NY, US

Assignee:

GENERAL ELECTRIC COMPANY - SCHENECTADY NY

International Classification:

C12M 1/42

US Classification:

4352891

Abstract:

A system for delivering exogenous molecules comprises a support for containing cells and exogenous molecules; an infra-red (IR) light source that generates an IR optical beam with an average power density at least greater than 10W/cm; one or more optical elements; an imaging system to image the cells in a field of view; a processor that generates a signal for localization of cells in the field of view; a light pattern shaper for temporal focusing of optical beam to generate wide field illumination on the cells to permeabilise the cell membrane for delivering the exogenous molecules; and a controller that switches optical beam from wide field illumination to a focused illumination. The processor is operatively coupled to the imaging system and the light pattern shaper and transmits the signal for the localization of cells to ensure the temporal focusing of the optical beam on the cells.

US Patent:

20130052738, Feb 28, 2013

Filed:

Aug 30, 2011

Appl. No.:

13/221161

Inventors:

Vasile Bogdan Neculaes - Niskayuna NY, US
Kenneth Roger Conway - Clifton Park NY, US
Allen Lawrence Garner - Clifton Park NY, US
Evelina Roxana Loghin - Rexford NY, US
Siavash Yazdanfar - Niskayuna NY, US
Dmitry Vladimirovich Dylov - Schenectady NY, US
Brian Michael Davis - Albany NY, US
Chulmin Joo - Niskayuna NY, US

Assignee:

GENERAL ELECTRIC COMPANY - SCHENECTADY NY

International Classification:

C12N 13/00
C12N 15/63
C12N 15/81
C12N 15/85
C12N 15/82
B82Y 5/00

US Classification:

435455, 4351735, 435468, 435471, 977773, 977902

Abstract:

A method of delivering exogenous molecules, comprising: providing a plurality of cells having a cell membrane; adding a plurality of exogenous molecules to the cells; exposing the cells to a defocused infrared (IR) light to permeabilize the cell membrane of the cells; and delivering the exogenous molecules to the cells through the permeablized cell membrane, wherein an intensity of the IR light at the optical focus is at least greater than or equal to an order of 10W/cm.