Courtney A Ober

US Patent:

20170072051, Mar 16, 2017

Filed:

Oct 24, 2016

Appl. No.:

15/332308

Inventors:

- Auburn AL, US
Ram B. Gupta - Auburn AL, US
Erfan U. Chowdhury - Auburn AL, US
Courtney A. Ober - Carlisle PA, US

Assignee:

Auburn University - Auburn AL

International Classification:

A61K 39/39
C12N 7/00
A61K 9/16
A61K 39/12
A61K 39/118
A61K 31/472

Abstract:

Disclosed are compositions, kits, and methods for inducing an immune response against an infection or a disease. The compositions typically include biodegradable particles having an average effective diameter that such that the biodegradable particles are phagocytosed by antigen presenting cells when the biodegradable particles are administered to a subject in need thereof. Optionally, the compositions include one or more of an adjuvant, an apoptosis inhibitor, and an antigen. The compositions, kits, and methods may be utilized to induce a cell-mediated response, such as a T-helper cell response, and/or a humoral response against a pathogen or a disease. In some embodiments, the compositions, kits, and methods may be utilized to induce preferentially a Th1 response versus other types of immune responses such as a Th2 response.

US Patent:

20150297706, Oct 22, 2015

Filed:

Mar 31, 2015

Appl. No.:

14/674711

Inventors:

- Auburn AL, US
Ram B. Gupta - Auburn AL, US
Erfan U. Chowdhury - Auburn AL, US
Courtney A. Ober - Carlisle PA, US

Assignee:

Auburn University - Auburn AL

International Classification:

A61K 39/12
C12N 7/00
A61K 9/16
A61K 31/47
A61K 39/118

Abstract:

Disclosed are compositions, kits, and methods for inducing an immune response against an infection or a disease. The compositions typically include biodegradable particles having an average effective diameter of 0.5-20 μm, and optionally the compositions include one or more of an adjuvant, an apoptosis inhibitor, and an antigen. The compositions, kits, and methods may be utilized to induce a cell-mediated response, such as a T-helper cell response, and/or a humoral response against a pathogen or a disease. In some embodiments, the compositions, kits, and methods may be utilized to induce preferentially a Th1 response versus other types of immune responses such as a Th2 response.