David H Leith

US Patent:

20120325084, Dec 27, 2012

Filed:

Jul 26, 2012

Appl. No.:

13/559004

Inventors:

Kenneth G. Sexton - Pittsboro NC, US
Harvey E. Jeffries - Chapel Hill NC, US
Ilona Jaspers - Chapel Hill NC, US
David H. Leith - Chapel Hill NC, US
Glenn W. Walters - Durham NC, US
Melanie Lynn Doyle-Eisele - Albuquerque NM, US
Kim M. Lichtveld - Durham NC, US
Sandra W. Irwin - Bridgewater NJ, US
James J. Jetter - Apex NC, US
Seth M. Ebersviller - Durham NC, US
William Vizuete - Chapel Hill NC, US
Jose Zavala Mendez - Chapel Hill NC, US

International Classification:

B03C 3/34
B03C 3/155

US Classification:

95 10, 96 58, 96 19, 95 69, 95 14, 95 8

Abstract:

Electrostatic aerosol in vitro exposure systems and methods are disclosed and can be used for collecting and depositing particulate matter onto tissue without pre-concentration, and without any intermediate collection steps such as use in water or on a filter. The system can include an inlet configured to receive air containing particulate matter, a receptacle configured to hold one or more tissue samples, a porous membrane providing support for an air-liquid interface of the tissue sample, and an electrostatic precipitation area. Particulate matter contained in the air received at the inlet can be electrically charged in the electrostatic precipitation area and flowed over the tissue sample, where it can be collected and measured.

US Patent:

54151627, May 16, 1995

Filed:

Jan 18, 1994

Appl. No.:

8/183283

Inventors:

Robert A. Casper - Raleigh NC
Malcolm E. Taylor - Pelham NH
Frank A. Leith - Chapel Hill NC
David H. Leith - Chapel Hill NC
Maryanne G. Boundy - Chapel Hill NC

Assignee:

Glaxo Inc. - Research Triangle Park NC

International Classification:

A61M 1500

US Classification:

12820312

Abstract:

A breath-actuated dry powder medicament inhalator device having a housing and a conduit mounted within the housing defining an air passageway therethrough having an aperture in the sidewall thereof. A blister-type strip of sealed containers arranged in a matrix of rows and columns wherein the columns extend generally diagonally to the longitudinal axis of the strip is secured in a two-piece cage adapted for being rotatably mounted around the conduit of the inhalator device. Advancement means are provided for rotatably moving the two-piece cage and blister strip contained thereby in a generally helical pathway relative to the conduit so as to successively advance each of the sealed containers of the blister strip into registration with the conduit aperture. Piercing means are associated with the housing for successively piercing each of the sealed containers of the blister strip when advanced into registration with the conduit aperture by the advancement means in order to introduce the dry powder compound contained therein into the air passageway of the conduit.

US Patent:

53041259, Apr 19, 1994

Filed:

Mar 23, 1993

Appl. No.:

8/035916

Inventors:

David H. Leith - Chapel Hill NC

Assignee:

The University of North Carolina - Chapel Hill NC

International Classification:

A61M 3100
A61M 1100

US Classification:

604 57

Abstract:

An apparatus for administering an aerosol of a solid particulate medicament (e. g. , amiloride) to the lungs of a patient is disclosed. The apparatus comprises a solid particulate medicament aerosol generator and an impactor assembly for removing large particles of medicament from the aerosol produced by the aerosol generator. The impactor assembly comprises an enclosed chamber having an inlet opening and an outlet opening formed on opposite sides thereof. The aerosol generator is connected to the inlet opening. A first impactor plate is positioned in the chamber, with the first impactor plate adjacent the inlet opening. The first impactor plate has an uninterrupted primary impaction surface formed thereon, with the primary impaction surface substantially axially aligned with the inlet opening and having a diameter not less than the inlet opening. The first impactor plate has at least one exhaust opening formed therein in fluid communication with the outlet opening. An aerosol of solid particulate medicament is passed from the aerosol generator through the impactor assembly where large particles are removed, and then to the subject for inhalation.

US Patent:

63216086, Nov 27, 2001

Filed:

Apr 7, 2000

Appl. No.:

9/544221

Inventors:

Jeff Wagner - Oakland CA
David Leith - Chapel Hill NC

Assignee:

The University of North Carolina - Chapel Hill - Chapel Hill NC

International Classification:

G01N 100

US Classification:

7386321

Abstract:

A miniature, passive aerosol particle sampler comprises a scanning electron microscopy mount provided with a collection surface and a removable mesh cover comprising a spacer ring and a mesh sheet. A sampling and analysis method comprises scanning electron microscopy and image analysis to determine a particle-count size distribution. A deposition velocity model comprising a theoretical component and an empirical component is used to determine from the particle-count size distribution the average airborne mass concentration of aerosol particles to which the sampler was exposed.

US Patent:

20230105847, Apr 6, 2023

Filed:

Oct 4, 2022

Appl. No.:

17/960029

Inventors:

- Fort Collins CO, US
John Volckens - Fort Collins CO, US
David Leith - Chapel Hill NC, US
Casey Quinn - Olympia WA, US
Bonnie Young - Fort Collins CO, US
John Kodros - Fort Collins CO, US

International Classification:

G01M 3/26
A62B 27/00

Abstract:

A system may include a computer-readable storage media configured to store instructions. The system may also include one or more processors communicatively coupled to the one or more computer-readable storage media. The one or more processors may be configured to, in response to execution of the instructions, cause the system to perform operations. The operations may include measuring a pressure of a volume while a user wears a mask and breathes. The volume may be defined by an interior surface of the mask and a face of the user. The operations may also include determining a differential pressure due to the mask. The differential pressure may be equal to a difference between the pressure of the volume and an ambient pressure of an environment proximate an exterior surface of the mask. In addition, the operations may include determining a mask leakage rate of the mask based on the differential pressure.

US Patent:

20200049598, Feb 13, 2020

Filed:

Oct 15, 2019

Appl. No.:

16/653546

Inventors:

- Fort Collins CO, US
Casey William Quinn - Olympia WA, US
John Volckens - Fort Collins CO, US
David Leith - Chapel Hill NC, US

International Classification:

G01N 1/22
G01N 15/06
G01N 15/02

Abstract:

A portable sampling device includes a housing at least partially enclosing an inner chamber and an airflow assembly disposed within the inner chamber and comprising a portion of an airflow path. The airflow assembly includes a portion of a printed circuit board (PCB); a manifold configured to be sealably coupled to the portion of the PCB to define at least one airflow channel disposed between an inner surface of the manifold and an outer surface of the PCB; and one or more pumping elements positioned on the PCB.

US Patent:

20170370809, Dec 28, 2017

Filed:

Feb 25, 2017

Appl. No.:

15/442657

Inventors:

- Fort Collins CO, US
Casey William Quinn - Olympia WA, US
John Volckens - Fort Collins CO, US
David Leith - Chapel Hill NC, US

International Classification:

G01N 1/22
G01N 15/02

Abstract:

A sampling device is constructed having an airflow path from a size-selective inlet to a device outlet, without using any tubing. The size-selective inlet includes at least one of an impactor, a filter, a cyclone, and an inhalable inlet. The device includes a sampling assembly configured to be removably coupled directly to a sampling device housing (e.g., without using tubing), and an airflow assembly that may be constructed without using tubing.

US Patent:

20160109349, Apr 21, 2016

Filed:

Oct 21, 2015

Appl. No.:

14/918798

Inventors:

- Fort Collins CO, US
Kimberly Anderson - Fort Collins CO, US
David Leith - Chapel Hill NC, US
Mwangi T. Ndonga - Broomfield CO, US
Azer Yalin - Fort Collins CO, US
Christopher M. Limbach - Fort Collins CO, US

International Classification:

G01N 15/02
H01J 49/16
G01N 21/71
G01J 3/443

Abstract:

Methods and systems for characterizing particles in an aerosol are disclosed. A system includes a collection container that utilizes the principles of elutriation to collect particles of selected aerodynamic diameter ranges within a measurement region. A particle detector is used to detect and characterize particles that have settled into the measurement region.