Dawn E Bowles

US Patent:

20080269149, Oct 30, 2008

Filed:

Dec 15, 2005

Appl. No.:

11/793430

Inventors:

Dawn E. Bowles - Durham NC, US
Chengwen Li - Chapel Hill NC, US
Joseph E. Rabinowitz - Secane PA, US
Josh Grieger - Chapel Hill NC, US
Richard Jude Samulski - Chapel Hill NC, US

International Classification:

A61K 31/7088
C12N 15/63
A61P 25/16
A61P 3/10
A61P 19/02
A61P 21/00
A61P 35/00

US Classification:

514 44, 4353201

Abstract:

The present invention is based, in part, on the discovery that parvovirus (including AAV) capsids can be engineered to incorporate small, selective regions from other parvoviruses that confer desirable properties. The inventors have discovered that in some cases as little as a single amino acid insertion or substitution from a first parvovirus (e.g., an AAV) into the capsid structure of another parvovirus (e.g., an AAV) to create a chimeric parvovirus is sufficient to confer one or more of the desirable properties of the first parvovirus to the resulting chimeric parvovirus and/or to confer a property that is not exhibited by the first parvovirus or is present to a lesser extent.

US Patent:

20110104119, May 5, 2011

Filed:

Jan 3, 2011

Appl. No.:

12/983547

Inventors:

Dawn E. Bowles - Durham NC, US
Chengwen Li - Chapel Hill NC, US
Joseph E. Rabinowitz - Secane PA, US
Josh Grieger - Chapel Hill NC, US
Richard Jude Samulski - Chapel Hill NC, US

International Classification:

A61K 35/76
C12N 5/00
A61P 21/00
A61P 3/10
A61P 9/00
A61P 35/00
A61P 27/02

US Classification:

424 932, 435325

Abstract:

The present invention is based, in part, on the discovery that parvovirus (including AAV) capsids can be engineered to incorporate small, selective regions from other parvoviruses that confer desirable properties. The inventors have discovered that in some cases as little as a single amino acid insertion or substitution from a first parvovirus (e.g., an AAV) into the capsid structure of another parvovirus (e.g., an AAV) to create a chimeric parvovirus is sufficient to confer one or more of the desirable properties of the first parvovirus to the resulting chimeric parvovirus and/or to confer a property that is not exhibited by the first parvovirus or is present to a lesser extent.

US Patent:

20200108109, Apr 9, 2020

Filed:

Oct 5, 2019

Appl. No.:

16/594017

Inventors:

- Durham NC, US
Carmelo Milano - Durham NC, US
Dawn Bowles - Durham NC, US

International Classification:

A61K 35/761
C12N 15/86
A01N 1/02
C12N 15/113

Abstract:

The present invention relates to methods of administering therapeutic agents to a donor organ prior to transplant comprising circulating the therapeutic agent through the donor organ while maintaining the donor organ under ex vivo perfusion conditions, as well as methods of transplanting organs, biologically modifying a donor organ prior to transplant, and treating organ failure using the methods disclosed herein.