Dawn E. Bowles - Durham NC, US Chengwen Li - Chapel Hill NC, US Joseph E. Rabinowitz - Secane PA, US Josh Grieger - Chapel Hill NC, US Richard Jude Samulski - Chapel Hill NC, US
The present invention is based, in part, on the discovery that parvovirus (including AAV) capsids can be engineered to incorporate small, selective regions from other parvoviruses that confer desirable properties. The inventors have discovered that in some cases as little as a single amino acid insertion or substitution from a first parvovirus (e.g., an AAV) into the capsid structure of another parvovirus (e.g., an AAV) to create a chimeric parvovirus is sufficient to confer one or more of the desirable properties of the first parvovirus to the resulting chimeric parvovirus and/or to confer a property that is not exhibited by the first parvovirus or is present to a lesser extent.
Dawn E. Bowles - Durham NC, US Chengwen Li - Chapel Hill NC, US Joseph E. Rabinowitz - Secane PA, US Josh Grieger - Chapel Hill NC, US Richard Jude Samulski - Chapel Hill NC, US
The present invention is based, in part, on the discovery that parvovirus (including AAV) capsids can be engineered to incorporate small, selective regions from other parvoviruses that confer desirable properties. The inventors have discovered that in some cases as little as a single amino acid insertion or substitution from a first parvovirus (e.g., an AAV) into the capsid structure of another parvovirus (e.g., an AAV) to create a chimeric parvovirus is sufficient to confer one or more of the desirable properties of the first parvovirus to the resulting chimeric parvovirus and/or to confer a property that is not exhibited by the first parvovirus or is present to a lesser extent.
Methods For The Delivery Of Therapeutic Agents To Donor Organs
- Durham NC, US Carmelo Milano - Durham NC, US Dawn Bowles - Durham NC, US
International Classification:
A61K 35/761 C12N 15/86 A01N 1/02 C12N 15/113
Abstract:
The present invention relates to methods of administering therapeutic agents to a donor organ prior to transplant comprising circulating the therapeutic agent through the donor organ while maintaining the donor organ under ex vivo perfusion conditions, as well as methods of transplanting organs, biologically modifying a donor organ prior to transplant, and treating organ failure using the methods disclosed herein.
Duke University since Oct 2004
Assistant Professor
UNC 1999 - 2004
Post doctoral fellow
Education:
Louisiana State University School of Medicine in Shreveport 1991 - 1998
PhD, Microbiology
University of Louisiana at Lafayette 1985 - 1990
B.S., microbiology
Skills:
Molecular Biology Microbiology Translational Research Animal Models Site-directed Mutagenesis DNA Molecular Cloning Research Experience Apoptosis Virology Physiology Mutagenesis Cell Biology Research Fluorescence Microscopy Protein Chemistry Biochemistry
Dawn Bowles 1985 graduate of Mifflin High School in Columbus, OH is on Memory Lane. Get caught up with Dawn and other high school alumni from Mifflin High