Medtronic Jun 2001 - May 2004
Principal Chemist
Medtronic Jun 2001 - May 2004
Principal Scientist
University of Minnesota Cardiovascular Division 1992 - 2001
Scientist
Education:
University of Minnesota
Bachelors, Bachelor of Science, Biochemistry, Chemistry
Skills:
Gmp Bioanalysis Fda Cross Functional Team Leadership Clinical Trials Formulation Analytical Chemistry Glp Biomedical Engineering Chemistry Design Control Biotechnology Biocompatibility Design of Experiments
Dianne Judd - Minneapolis MN, US William Ferris - Minneapolis MN, US
Assignee:
MEDTRONIC, INC. - Minneapolis MN
International Classification:
A61L 2/00
US Classification:
422 22, 424423
Abstract:
A sterilized medical device comprising minocycline and rifampin is described. The device is setrerilized by e-beam raditation such that degradation of minocycline and rifampin is minimized. Methods for sterilizing minocycline and rifampin-containing devices by e-beam radiation and methods of manufacturing devices, which methods include e-beam sterilization, are also described.
Methods For Compounding And Delivering A Therapeutic Agent To The Adventitia Of A Vessel
Patrice Tremble - Santa Rosa CA, US Dianne Judd - Minneapolis MN, US Kishore Udipi - Santa Rosa CA, US Peiwen Cheng - Santa Rosa CA, US Rangarajan Sundar - Santa Rosa CA, US Kaushik A. Patel - Windsor CA, US Eugene Tedeschi - Santa Rosa CA, US
Assignee:
Medtronic Vascular, Inc - Santa Rosa CA
International Classification:
A61M 25/10 A61M 25/06 A61K 9/14 A61P 9/02
US Classification:
604509, 604508, 424489
Abstract:
The invention provides a method of delivering a therapeutic agent to the adventitia of a vessel using a catheter-based microsyringe. A therapeutic agent is formed into microparticles, which are dispersed throughout an appropriate liquid carrier to form a therapeutic mixture. A catheter is provided that includes a microsyringe operably attached to an actuator. The microsyringe includes a hollow needle in fluid communication with a therapeutic agent delivery conduit. The catheter is introduced into a target area of a vessel. The actuator is operated to thrust the needle into a wall of the vessel. The therapeutic mixture is supplied to the therapeutic agent delivery conduit and delivered through the conduit to the needle and thereby into the adventitia of the vessel. The actuator is again operated to withdraw the needle from the wall of the vessel and to enclose it within the actuator. The catheter is then removed from the vessel.
Chimeric Natriuretic Peptide Compositions And Methods Of Preparation
William Van Antwerp - Valencia CA, US Andrew J. L. Walsh - Minneapolis MN, US Lian Luo - Plymouth MN, US Dianne L. Judd - Minneapolis MN, US
Assignee:
NILE THERAPEUTICS, INC. - San Mateo CA MEDTRONIC, INC. - Minneapolis MN
International Classification:
A61K 38/22
US Classification:
514 124
Abstract:
Therapeutic compositions containing chimeric natriuretic peptides for treating chronic kidney disease alone, heart failure alone, or chronic kidney disease with concomitant heart failure are described. The therapeutic compositions have enhanced stability characteristics to facilitate storage and delivery by provisioning apparatuses under conditions of elevated temperature and mechanical stress. Methods for increasing the stability of therapeutic compositions containing chimeric natriuretic peptides are further described.
Use Of Fatty Acids To Inhibit The Growth Of Aneurysms
David Brin - West Newbury MA, US Jack Chu - Santa Rosa CA, US Prema Ganesan - San Francisco CA, US Dianne Judd - Minneapolis MN, US Michel Letort - Prevessins, FR Patrice Tremble - Santa Rosa CA, US Eugene Tedeschi - Santa Rosa CA, US
Assignee:
Medtronic Vascular, Inc. - Santa Rosa CA
International Classification:
A61K 31/202
US Classification:
424423000, 514560000
Abstract:
Methods of treating an aneurysm in a patient in need thereof are provided. The methods comprise delivering to a treatment site an effective amount of a fatty acid inhibitor of a matrix metalloproteinase (MMP) such that the fatty acid inhibitor of the MMP causes the regression of a pre-existing aneurysm. Additionally, an implantable medical device is provided for implanting in a vessel wall of a patient comprising a structural support and a fatty acid inhibitor of an MMP.
Chimeric Natriuretic Peptide Compositions And Methods Of Preparation
Therapeutic compositions containing chimeric natriuretic peptides for treating chronic kidney disease alone, heart failure alone, or chronic kidney disease with concomitant heart failure are described. The therapeutic compositions have enhanced stability characteristics to facilitate storage and delivery by provisioning apparatuses under conditions of elevated temperature and mechanical stress. Methods for increasing the stability of therapeutic compositions containing chimeric natriuretic peptides are further described.
Urease Purification From Jack Beans Or Other Organisms
- Minneapolis MN, US Dianne L. Judd - Minneapolis MN, US Cindy Roberson - Plymouth MN, US Eric Hall - Plymouth MN, US
Assignee:
Medtronic, Inc. - Minneapolis MN
International Classification:
C12N 9/80
Abstract:
A method for the extraction and purification of urease from jack beans or other natural sources of urease. The method provides an efficient way to obtain purified urease from natural sources. The method can include defatting the natural sources of urease, extracting the urease from impurities, and further purification of the extracted urease.
Natriuretic Peptide Compositions And Methods Of Preparation
William Van Antwerp - Valencia CA, US Dianne Judd - Minneapolis MN, US Andrew Walsh - Minneapolis MN, US Lian Luo - Plymouth MN, US
Assignee:
MEDTRONIC, INC. - Minneapolis MN
International Classification:
C07K 14/58
US Classification:
514 124
Abstract:
Therapeutic compositions containing natriuretic peptides for treating chronic kidney disease alone, heart failure alone, or chronic kidney disease with concomitant heart failure are described. The therapeutic compositions have enhanced stability characteristics to facilitate storage and delivery by provisioning apparatuses under conditions of elevated temperature and mechanical stress. Methods for increasing the stability of therapeutic compositions containing natriuretic peptides are further described.