Donald Osvaldo Freytes

US Patent:

20110136225, Jun 9, 2011

Filed:

Dec 6, 2010

Appl. No.:

12/961309

Inventors:

Warren Grayson - New York NY, US
Qun Wan - New York NY, US
Donald Freytes - Nutley NJ, US
Nina Tandon - New York NY, US
Keith Yeager - Jersey City NJ, US
George Eng - New York NJ, US
Sarindr Bhumiratana - New York NY, US
Robert Maidhof - North Valley Stream NY, US

Assignee:

The Trustees of Columbia University in the City of New York - New York NY

International Classification:

C12N 5/071
C12M 3/00
C12M 1/34

US Classification:

435325, 4352891, 4352887

Abstract:

Disclosed are bioreactor devices, systems and methods. A bioreactor system can include one or more bioreactor modules that can be individually controllable and identifiable. A bioreactor module can be connected to one or more functional modules such as a pump module, a stimulation signal generation module, a motor module, a mechanical transmission module, a gas exchange module, a temperature module, a humidity module and/or a COmodule, among others. The bioreactor and functional modules can include standard or universal connectors to facilitate connection and movement of modules. The bioreactor system can be controlled and/or monitored by a controller that can individually identify and control each connected module and that can be adapted to collect signal data from sensors embedded in any of the modules.

US Patent:

20160053214, Feb 25, 2016

Filed:

Nov 2, 2015

Appl. No.:

14/929560

Inventors:

- New York NY, US
Warren GRAYSON - New York NY, US
Qun WAN - New York NY, US
Donald O. FREYTES - Nutley NJ, US
Nina TANDON - New York NY, US
Keith YEAGER - Jersey City NJ, US
George ENG - New York NY, US
Sarindr BHUMIRATANA - Woodside NY, US
Robert MAIDHOF - North Valley Stream NY, US

International Classification:

C12M 3/00
C12M 1/34
C12M 1/42
C12M 1/36
C12M 1/00
C12M 1/12

Abstract:

Disclosed are bioreactor devices, systems and methods. A bioreactor system can include one or more bioreactor modules that can be individually controllable and identifiable. A bioreactor module can be connected to one or more functional modules such as a pump module, a stimulation signal generation module, a motor module, a mechanical transmission module, a gas exchange module, a temperature module, a humidity module and/or a COmodule, among others. The bioreactor and functional modules can include standard or universal connectors to facilitate connection and movement of modules. The bioreactor system can be controlled and/or monitored by a controller that can individually identify and control each connected module and that can be adapted to collect signal data from sensors embedded in any of the modules.

US Patent:

20140322696, Oct 30, 2014

Filed:

Apr 4, 2014

Appl. No.:

14/245387

Inventors:

- New York NY, US
JOSHUA SONETT - HO HO KUS NJ, US
JOHN O'NEILL - NEW YORK NY, US
MATTHEW BACCHETTA - NEW YORK NY, US
DONALD O. FREYTES - SUMMIT NJ, US
GOPAL SINGH - NEW YORK NY, US
SCOTT A. KANNER - BROOKLYN NY, US

Assignee:

The Trustees of Columbia University in the City of New York - New York NY

International Classification:

A01N 1/02

US Classification:

435 12, 4352841

Abstract:

The vasculature of a donor lung is perfused with a lung preserving fluid to preserve its structure. At the same time, a decellularization fluid is perfused through the airways, which strips away donor cells. The decellularized region is then seeded with pulmonary cells of the transplant recipient, which regenerate the lung. The pulmonary cells may be derived from stem cells, and the decellularization can be targeted to reduce the quantity of cells required.