Dongyul Chai

US Patent:

20120330291, Dec 27, 2012

Filed:

Jun 14, 2012

Appl. No.:

13/523058

Inventors:

James V. Jester - Irvine CA, US
Tibor Juhasz - Corona del Mar CA, US
Donald J. Brown - Santa Clarita CA, US
Dongyul Chai - Costa Mesa CA, US
Moritz Winkler - Irvine CA, US

Assignee:

THE REGENTS OF THE UNIVERSITY OF CALIFORNIA - Oakland CA

International Classification:

A61F 9/01

US Classification:

606 5

Abstract:

The embodiments include method of nonlinear optical photodynamic therapy of tissue including the steps of providing pulsed infrared laser light for two-photon excited fluorescence tissue exposure, and selectively focusing the pulsed infrared laser light within the tissue at a focal plane to activate a photosensitizing agent to generate free radicals within a highly resolved axial and lateral spatial domain in the tissue. The invention is also directed to an apparatus for performing nonlinear optical photodynamic therapy of tissue including a pulsed infrared laser for providing two-photon excited fluorescence beam tissue exposure, a scanner for selectively and controllably moving the tissue and the beam relative to each other, and optics for selectively focusing the pulsed infrared laser light within the tissue at a point in a focal plane to activate a photosensitizing agent to generate free radicals within a highly resolved axial and lateral spatial domain in the tissue.

US Patent:

20150320599, Nov 12, 2015

Filed:

Jul 20, 2015

Appl. No.:

14/803451

Inventors:

- Oakland CA, US
Tibor Juhasz - Corona del Mar CA, US
Donald J. Brown - Santa Clarita CA, US
Dongyul Chai - Costa Mesa CA, US
Moritz Winkler - Irvine CA, US

International Classification:

A61F 9/008

Abstract:

The embodiments include method of nonlinear optical photodynamic therapy of tissue including the steps of providing pulsed infrared laser light for two-photon excited fluorescence tissue exposure, and selectively focusing the pulsed infrared laser light within the tissue at a focal plane to activate a photosensitizing agent to generate free radicals within a highly resolved axial and lateral spatial domain in the tissue. The invention is also directed to an apparatus for performing nonlinear optical photodynamic therapy of tissue including a pulsed infrared laser for providing two-photon excited fluorescence beam tissue exposure, a scanner for selectively and controllably moving the tissue and the beam relative to each other, and optics for selectively focusing the pulsed infrared laser light within the tissue at a point in a focal plane to activate a photosensitizing agent to generate free radicals within a highly resolved axial and lateral spatial domain in the tissue.