The invention is directed to a phosphonate composition having flame retardant properties. The phosphonate composition of the invention has the general formula:The invention is also directed to a method of producing the phosphonate composition having flame retardant properties.
Mixtures of three types of linear, branched or cyclic phosphates are useful flame retardants, especially for thermoplastic resins or as functional additives in polymer matrices.
Francine Palmer - Hoschton GA, US James Ellis - Warwick, GB James Horn - Freehold NJ, US Eugene Anderson - Marlton NJ, US Dwight Shamblee - North Charleston SC, US Gary Woodward - Northwich, GB
International Classification:
A01N 57/20 A01P 21/00 C07F 9/38
US Classification:
504127000, 568016000
Abstract:
A method for making a plant growth regulator includes the step of reacting vinyl chloride with a phosphorous reagent.
Compounds Having One Or More Aminosulfaonyloxy Radicals Useful As Pharmaceuticals
Young S. Lo - Hockessin DE Joseph C. Nolan - Midlothian VA William J. Welstead - Richmond VA David A. Walsh - Augusta GA Dwight A. Shamblee - Richmond VA Ibrahim M. Uwaydah - Richmond VA
Assignee:
A. H. Robins Company, Incorporated - Richmond VA
International Classification:
C07C30963 A61K 3118 A61K 31315
US Classification:
514494
Abstract:
Methods of treating chronic arthritis and osteoporosis which utilize both known and novel compounds which would fall under the general formula: (HO)p--A--[--OS(O). sub. 2 NR. sup. 1 R. sup. 2 ]. sub. z wherein A encompasses a wide range of values including but not limited to aryl, loweralkyl, cycloalkyl, and carbohydrates including sucrose and fructose; p is equal to the number of unreacted hydroxy groups contained on the molecule and may be zero; z is the number of --OS(O). sub. 2 NR. sup. 1 R. sup. 2 groups and is always at least one; R. sup. 1 and R. sup. 2 are selected from hydrogen, loweralkyl, carboxy and the like; a novel process for preparing the compounds is provided wherein an appropriate sulfamic acid aryl ester is reacted with a hydroxy substituted A radical which may or may not contain thereon protected carboxyl, amino or hydroxy substituents, in an aprotic solvent containing a tertiary amine base. Pharmaceutical compositions for the treatment of chronic arthritis and osteoporosis are also provided.
David A. Walsh - Richmond VA Dwight A. Shamblee - Richmond VA
Assignee:
A. H. Robins Company, Inc. - Richmond VA
International Classification:
C07D20714 A61K 3140
US Classification:
424274
Abstract:
Cis and trans 3-amino-4-hydroxypyrrolidines and derivatives thereof are disclosed having the formula: ##STR1## wherein R. sub. 1 is hydrogen, loweralkyl or phenylcarbonyl; R. sub. 2 is hydrogen, loweralkyl, lowercycloalkyl, phenyl or phenylloweralkyl; R. sub. 3 is hydrogen, loweralkyl, phenylloweralkyl, phenylcarbonyl, diphenylmethyl, 5-yl-10,11-dihydro-5H-dibenzo[a,d]cycloheptene or naphthylcarbonyl; R. sub. 4 is hydrogen, loweralkyl, phenylloweralkyl or lowercycloalkyl; phenyl is optionally substituted and acid addition salts thereof. The compounds have antidepressant activity and methods and pharmaceutical compositions for use thereof are disclosed.
David A. Walsh - Richmond VA Dwight A. Shamblee - Richmond VA
Assignee:
A. H. Robins Company, Incorporated - Richmond VA
International Classification:
C07C14943 A61K 3124 A61K 31195
US Classification:
514539
Abstract:
Novel 2-amino-3-(alkylthiobenzoyl)phenylacetic acids, esters and metal salts have the formula: ##STR1## wherein R is hydrogen or lower alkyl, R. sup. 1 is hydrogen, lower alkyl or pharmaceutically acceptable metal cation, R. sup. 2 is hydrogen, halogen, lower alkyl or lower alkoxy, Am is primary amino (--NH. sub. 2), methylamino or dimethylamino. The compounds have anti-inflammatory activity; have effective analgesic activity, and inhibit blood platelet aggregation.
Method Of Producing An Inhibitory Effect On Blood Platelet Aggregation
James R. Shanklin - Richmond VA Dwight A. Shamblee - Richmond VA David A. Walsh - Richmond VA
Assignee:
A. H. Robins Company, Inc. - Richmond VA
International Classification:
A61K 31535 A61K 31165
US Classification:
42424856
Abstract:
Novel 2-amino-3-benzoyl-phenylacetamides are provided having the formula: ##STR1## wherein R represents hydrogen or lower alkyl, R. sup. 1 and R. sup. 2 represent hydrogen, lower alkyl, cycloalkyl, phenyl and phenyl substituted by lower alkyl, lower alkoxy, halogen, nitro and trifluoromethyl, and R. sup. 1 and R. sup. 2 when taken together with the adjacent nitrogen may form a heterocyclic residue; X represents hydrogen, lower alkyl, lower alkoxy, halogen or trifluoromethyl; Y represents hydrogen, lower alkyl, lower alkoxy, halogen, trifluoromethyl, lower alkylthio, lower alkyloxythio or lower alkyldioxythio; Am is primary amino (--NH. sub. 2), methylamino or dimethylamino, and n is 1 to 3 inclusive. The compounds exhibit anti-inflammatory, antipyretic, anti-blood platelet aggregation and analgetic pharmacological activities.