Eddy W Yue

US Patent:

6407103, Jun 18, 2002

Filed:

Dec 6, 2000

Appl. No.:

09/731304

Inventors:

David A. Nugiel - Cherry Hill NJ
David J. Carini - Wilmington DE
Susan V. Di Meo - Wilmington DE
Eddy W. Yue - Landenberg PA

Assignee:

Bristol-Myers Squibb Pharma Company - Wilmington DE

International Classification:

A61K 315377

US Classification:

5142328, 514403, 544 585, 544 586, 544121, 544130, 544131, 544140, 544 80, 544357, 544364, 544371, 546139, 546199, 546256, 5462697, 5462714, 5462721, 5462727, 5462757, 548181, 548236, 548247, 5483117, 5483591

Abstract:

The present invention relates to the synthesis of a new class of indeno[1,2-c]pyrazol-4-ones of formula (I): that are potent inhibitors of the class of enzymes known as cyclin dependent kinases, which relate to the catalytic subunits cdk1-9 and their regulatory subunits know as cyclins A-H. This invention also provides a novel method of treating cancer or other proliferative diseases by administering a therapeutically effective amount of one of these compounds or a pharmaceutically acceptable salt form thereof. Alternatively, one can treat cancer or other proliferative diseases by administering a therapeutically effective combination of one of the compounds of the present invention and one or more other known anti-cancer or anti-proliferative agents.

US Patent:

6413957, Jul 2, 2002

Filed:

Aug 15, 2000

Appl. No.:

09/639618

Inventors:

David A. Nugiel - Cherry Hill NJ
David J. Carini - Willmington DE
Susan V. Di Meo - Willmington DE
Eddy W. Yue - Landenberg PA

Assignee:

Bristol-Myers Suibb Pharma Company - Wilmington DE

International Classification:

A61K 315377

US Classification:

5142328, 514403, 5483591

Abstract:

The present invention relates to the synthesis of a new class of indeno[1,2-c]pyrazol-4-ones of formula (I): that are potent inhibitors of the class of enzymes known as cyclin dependent kinases, which relate to the catalytic subunits cdk1-7 and their regulatory subunits know as cyclins A-G. This invention also provides a novel method of treating cancer or other proliferative diseases by administering a therapeutically effective amount of one of these compounds or a pharmaceutically acceptable salt form thereof. Alternatively, one can treat cancer or other proliferative diseases by administering a therapeutically effective combination of one of the compounds of the present invention and one or more other known anti-cancer or anti-proliferative agents.

US Patent:

6593356, Jul 15, 2003

Filed:

Jul 16, 2001

Appl. No.:

09/906963

Inventors:

David Nugiel - Cherry Hill NJ
David Carini - Wilmington DE
Susan DiMeo - Wilmington DE
Anup Vidwans - Avondale PA
Eddy Yue - Landenberg PA

Assignee:

Bristol-Myers Squibb Pharma Company - Princeton NJ

International Classification:

A61K 31416

US Classification:

514403, 5483591

Abstract:

The present invention relates to the synthesis of a new class of indeno[1,2-c]pyrazol-4-ones of formula (I): that are potent inhibitors of the class of enzymes known as cyclin dependent kinases, which relate to the catalytic subunits cdk1-7 and their regulatory subunits know as cyclins A-G. This invention also provides a novel method of treating cancer or other proliferative diseases by administering a therapeutically effective amount of one of these compounds or a pharmaceutically acceptable salt form thereof. Alternatively, one can treat cancer or other proliferative diseases by administering a therapeutically effective combination of one of the compounds of the present invention and one or more other known anti-cancer or anti-proliferative agents.

US Patent:

6706718, Mar 16, 2004

Filed:

Nov 30, 2001

Appl. No.:

10/000820

Inventors:

Eddy W. Yue - Landenberg PA

Assignee:

Bristol-Myers Squibb Company - Princeton NJ

International Classification:

A61K 31427

US Classification:

51425404, 5142368, 514326, 514365, 544133, 544367, 546209, 548181

Abstract:

The present invention relates to 3-(2,4-dimethylthiazol-5-yl)indeno[1,2-c]pyrazol-4-ones of formula I: which are potent inhibitors of cyclin dependent kinases. This invention also provides a novel method of treating cancer or other proliferative diseases by administering a therapeutically effective amount of one of these compounds or a pharmaceutically acceptable salt form thereof. Alternatively, one can treat cancer or other proliferative diseases by administering a therapeutically effective combination of one of the compounds of the present invention and one or more other known anti-cancer or anti-proliferative agents.

US Patent:

6844318, Jan 18, 2005

Filed:

Mar 15, 2001

Appl. No.:

09/808832

Inventors:

Robert A. Copeland - Hockessin DE, US
Charles F. Albright - West Chester PA, US
Andrew P. Combs - Kennett Square PA, US
Randine L. Dowling - Wilmington DE, US
Nilsa R. Graciani - Wilmington DE, US
Wei Han - Newark DE, US
C. Anne Higley - Newark DE, US
Pearl S. Huang - Lansdale PA, US
Eddy W. Yue - Landenberg PA, US
Susan V. DiMeo - Wilmington DE, US

Assignee:

Bristol Myers Squibb Pharma Company - Princeton NJ

International Classification:

A61K 3807
A61K 3808
A61K 3814
A61K 31704

US Classification:

514 8, 514 16, 514 17, 514 18, 514 34, 530322, 530328, 530329, 530330, 536 64

Abstract:

This invention is directed to antineoplastic agents conjugated to enzyme-cleavable peptides comprising the amino acid recognition sequence of a membrane-bound and/or cell-secreted peptidase, and to the use of such conjugated compounds as chemotherapeutic agents in the targeted treatment of cancers.

US Patent:

7250435, Jul 31, 2007

Filed:

Feb 24, 2005

Appl. No.:

11/064758

Inventors:

David A. Nugiel - Cherry Hill NJ, US
David J. Carini - Wallingford CT, US
Susan V. Di Meo - New City NY, US
Anup P. Vidwans - Chicago IL, US
Eddy Yue - Landenberg PA, US

Assignee:

Bristol-Myers Squibb Pharma Company - Princeton NJ

International Classification:

A61K 31/415
C07D 231/54

US Classification:

514403, 5483591

Abstract:

The present invention relates to the synthesis of a new class of indeno[1,2-c]pyrazol-4-ones of formula (I):This invention also provides a novel method of treating cancer or other proliferative diseases by administering a therapeutically effective amount of one of these compounds or a pharmaceutically acceptable salt form thereof. Alternatively, one can treat cancer or other proliferative diseases by administering a therapeutically effective combination of one of the compounds of the present invention and one or more other known anti-cancer or anti-proliferative agents.

US Patent:

8034953, Oct 11, 2011

Filed:

May 9, 2006

Appl. No.:

11/430441

Inventors:

Andrew P. Combs - Kennett Square PA, US
Eddy W. Yue - Landenberg PA, US

Assignee:

Incyte Corporation - Wilmington DE

International Classification:

A61K 31/4245
C07D 271/08
C07D 413/04
C07D 413/12
C07D 413/14

US Classification:

548125, 5142275, 5142362, 51425403, 514256, 514314, 514326, 514364, 514340, 544138, 544 582, 544333, 544367, 546167, 546210, 5462691, 5462694

Abstract:

The present invention is directed to modulators of indoleamine 2,3-dioxygenase (IDO), as well as compositions and pharmaceutical methods thereof.

US Patent:

8088803, Jan 3, 2012

Filed:

Jul 7, 2009

Appl. No.:

12/498782

Inventors:

Andrew P. Combs - Kennett Square PA, US
Eddy W. Yue - Landenberg PA, US
Richard B. Sparks - Boothwyn PA, US
Wenyu Zhu - Media PA, US

Assignee:

Incyte Corporation - Wilmington DE

International Classification:

A61K 31/4245
C07D 413/12
C07D 271/08

US Classification:

514364, 548125

Abstract:

The present invention is directed to 1,2,5-oxadiazole derivatives, and compositions of the same, which are inhibitors of indoleamine 2,3-dioxygenase and are useful in the treatment of cancer and other disorders, and to the processes and intermediates for making such 1,2,5-oxadiazole derivatives.

Author:

Eddy W. Yue

ISBN #:

0849337747