Edith C Wolff

age ~95

from Bethesda, MD

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Connected to:

Edith Wolff Phones & Addresses

7917 Deepwell Dr, Bethesda, MD 20817 • 3013651405

Work

Company:

National institutes of health
Address:

9000 Rckvlle Pike Bldg 31, Bethesda, MD 20892
Phones:

3014964000
Position:

Biochemist ret
Industries:

Administration of Public Health Programs

Ranks

Licence:

Washington - Active
Date:

1989

Us Patents

Methods Of Inhibiting Formation Of Vascular Channels And Methods Of Inhibiting Proliferation
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US Patent:

7141589, Nov 28, 2006
Filed:

Aug 23, 2002
Appl. No.:

10/486671
Inventors:

Myung Hee Park - Potomac MD, US
Paul M Clement - Bethesda MD, US
Edith C. Wolff - Bethesda MD, US
Hynda K Kleinman - Kensington MD, US
Bernadette M Cracchiolo - Edgewater NJ, US
Assignee:

The United States of America as represented by the Department of Health and Human Services - Washington DC
University of Medicine and Dentistry of New Jersey - New Brunswick NJ
International Classification:

A61K 31/44
A61K 38/00
US Classification:

514345, 514 2
Abstract:

A method of inhibiting formation of vascular channels in tissues and a method of inhibiting proliferation of a cell of a non-vascularized intraepithelial neoplasia, both of which methods comprise administering to the tissues or the cell a compound.

Methods Of Diagnosing And Treating Hyperproliferative Disorders
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US Patent:

20090253777, Oct 8, 2009
Filed:

Sep 13, 2003
Appl. No.:

10/527453
Inventors:

Myung-Hee Park - Potomac MD, US
Edith C. Wolff - Bethesda MD, US
Bernadette M. Cracciolo - Edgewater NJ, US
Anthony Popowicz - Farmingville NY, US
Paul M.J. Clement - Heverlee, BE
International Classification:

A61K 31/7088
C07K 16/18
G01N 33/574
G01N 33/566
C12N 5/06
US Classification:

514 44 R, 5303879, 435 723, 436501, 435375
Abstract:

The invention relates to compositions and methods for diagnosing and treating hyperproliferative disorders using ligands which specifically recognize the hypusine and/or folate binding region of mature eukaryotic translation initiation factor 5A (hypusine-containing eIF-5A). The invention further relates to methods of identifying molecules which displace immunoreagents binding to mature eIF-5A. Such agents are useful for treating hyperproliferative disorders.

Method Of Preventing Survival Of Retrovirally Cells And Of Inhibiting Formation Of Infectious Retroviruses
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US Patent:

20120095058, Apr 19, 2012
Filed:

Dec 1, 2004
Appl. No.:

10/581658
Inventors:

Paul Palumbo - Westfield NJ, US
Myung-Hee Park - Potomac MD, US
Edith Wolff - Bethesda MD, US
Axel-Rainer Hanauske - Frankfurt, DE
Michael B. Mathews - Montclair NJ, US
Deepti Saxena - South Orange NJ, US
Mainul Hoque - Newark NJ, US
International Classification:

A61K 31/4418
A61K 31/4439
A61K 31/4412
A61P 31/18
A61P 31/14
C12N 5/071
A61K 31/426
A61P 31/12
US Classification:

514342, 514345, 514365, 435375, 514348
Abstract:

The present invention discloses compounds and pharmaceutical compositions which are highly effective at inhibiting the accumulation of spliced and unspliced viral transcripts and their utilization for viral protein synthesis at cellular ribosomes, and at inhibiting the formation of the hypusine residue in cellular eIF-5A precursor proteins, the cellular cofactors that render spliced and unspliced viral transcripts translatable at the ribosomes of infectled cells. The invention further relates to methods of using such compounds and pharmaceutical compositions therefrom for inhibiting or preventing viral protein synthesis. Such inhibition cause a dose-dependent release from the virally induced arrest of the otherwise genetically preprogrammed apoptosis of virally infected cells, and in consequence, triggers their apoptotic ablation and the eradication of the chronic infection-mediating provirus integrated into their genome.

Compositions And Methods For Inhibiting Deoxyhypusine Synthase And The Growth Of Cells
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US Patent:

53448464, Sep 6, 1994
Filed:

Dec 30, 1992
Appl. No.:

7/998231
Inventors:

Judit Jakus - Silver Spring MD
Myung H. Park - Potomac MD
Edith C. Wolff - Bethesda MD
John E. Folk - Derwood MD
Assignee:

The United States of America as represented by the Department of Health
and Human Services - Washington DC
International Classification:

C07C27904
A61K 31155
US Classification:

514634
Abstract:

Compositions and methods for the treatment of mammalian cells to inhibit cell growth, especially for inhibiting the proliferative cell growth associated with malignant and non-malignant disease, are provided. More particularly, a deoxyhypusine synthase inhibitor, typically, a mono- or bisguanyl diamine or polyamine, is administered to the cells. Also provided by this invention are diagnostic methods and kits for screening the cells of a patient to determine the effect of the deoxyhypusine synthase inhibitor on proliferation of the cells.

Methods Of Diagnosing And Treating Hyperproliferative Disorders
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US Patent:

20180237517, Aug 23, 2018
Filed:

Jan 2, 2014
Appl. No.:

14/146387
Inventors:

Myung-Hee Park - Potomac MD, US
Edith C. Wolff - Bethesda MD, US
Bernadette M. Cracchiolo - Edgewater NJ, US
Anthony Popowicz - Farmingville NY, US
Paul M. Clement - Heverlee, BE
Assignee:

RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY - New Brunswick NJ
International Classification:

C07K 16/28
C07K 16/30
G01N 33/68
G01N 33/574
Abstract:

The invention relates to compositions and methods for diagnosing and treating hyperproliferative disorders using ligands which specifically recognize the hypusine and/or folate binding region of mature eukaryotic translation initiation factor 5A (hypusine-containing eIF-5A). The invention further relates to methods of identifying molecules which displace immunoreagents binding to mature eIF-5A. Such agents are useful for treating hyperproliferative disorders.