Enugurthi Brahmachary from 11795 Spruce Run Dr, San Diego, CA 92131, age 54, Phone: 8585473527

Us Patents

Selective Sphingosine 1 Phosphate Receptor Modulators And Methods Of Chiral Synthesis
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US Patent:

8362048, Jan 29, 2013
Filed:

Nov 15, 2010
Appl. No.:

12/946819
Inventors:

Esther Martinborough - San Diego CA, US
Marcus F. Boehm - San Diego CA, US
Adam Richard Yeager - San Diego CA, US
Junko Tamiya - Carlsbad CA, US
Liming Huang - San Diego CA, US
Enugurthi Brahmachary - San Diego CA, US
Manisha Moorjani - San Diego CA, US
Gregg Alan Timony - Cardiff by the Sea CA, US
Jennifer L. Brooks - Encinitas CA, US
Robert Peach - San Diego CA, US
Fiona Lorraine Scott - San Diego CA, US
Michael Allen Hanson - San Marcos CA, US
Assignee:

Receptos, Inc. - San Diego CA
International Classification:

A61K 31/4245
C07D 271/06
US Classification:

514364, 548131
Abstract:

Compounds that selectively modulate the sphingosine 1 phosphate receptor are provided including compounds which modulate subtype 1 of the S1P receptor. Methods of chiral synthesis of such compounds is provided. Uses, methods of treatment or prevention and methods of preparing inventive compositions including inventive compounds are provided in connection with the treatment or prevention of diseases, malconditions, and disorders for which modulation of the sphingosine 1 phosphate receptor is medically indicated.

Selective Heterocyclic Sphingosine 1 Phosphate Receptor Modulators
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US Patent:

8507538, Aug 13, 2013
Filed:

Nov 15, 2010
Appl. No.:

12/946828
Inventors:

Marcus F. Boehm - San Diego CA, US
Esther Martinborough - San Diego CA, US
Enugurthi Brahmachary - San Diego CA, US
Manisha Moorjani - San Diego CA, US
Junko Tamiya - Carlsbad CA, US
Liming Huang - San Diego CA, US
Adam Richard Yeager - San Diego CA, US
Assignee:

Receptos, Inc. - San Diego CA
International Classification:

A61K 31/5377
A61K 31/496
A61K 31/454
A61K 31/433
A61K 31/427
A61K 31/426
A61K 31/425
A61K 31/381
C07D 417/12
C07D 417/10
C07D 333/24
C07D 333/22
C07D 333/20
C07D 333/16
C07D 277/30
C07D 277/28
C07D 277/24
C07D 285/12
C07D 285/10
C07D 285/08
US Classification:

514363, 5142368, 514319, 514365, 51425402, 514438, 544367, 544369, 544133, 544134, 546205, 546206, 548136, 548203, 548204, 548205, 549 75, 549 78
Abstract:

Compounds that selectively modulate the sphingosine 1 phosphate receptor are provided including compounds which modulate subtype 1 of the S1P receptor. Methods of chiral synthesis of such compounds is provided. Uses, methods of treatment or prevention and methods of preparing inventive compositions including inventive compounds are provided in connection with the treatment or prevention of diseases, malconditions, and disorders for which modulation of the sphingosine 1 phosphate receptor is medically indicated.

Piperazine And Piperidine Biaryl Derivatives
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US Patent:

20070259879, Nov 8, 2007
Filed:

Mar 6, 2007
Appl. No.:

11/714539
Inventors:

Rong Lu - Chapel Hill NC, US
John Tucker - San Diego CA, US
Jason Pickens - San Diego CA, US
Tatiana Zinevitch - Moscow, RU
Sergey Sviridov - Moscow, RU
Vitaly Konoplev - Toulskaya, RU
Enugurthi Brahmachary - San Diego CA, US
International Classification:

A61K 31/505
A61K 31/497
A61P 37/00
C07D 241/36
C07D 401/02
C07D 403/02
C07D 405/02
C07D 413/02
C07D 495/02
US Classification:

514252130, 514253010, 514253060, 514254020, 514254030, 514254050, 514254080, 514255020, 514274000, 544278000, 544295000, 544360000, 544363000, 544366000, 544367000, 544369000, 544370000, 544371000, 544373000, 544374000, 544383000
Abstract:

This invention relates to piperazine and piperidine biaryl compounds of Formula (I): or a pharmaceutically acceptable prodrug, salt, polymorph, solvate, enantiomer, diastereomer, racemate, mixture of stereoisomers thereof, or derivative thereof; and to processes for preparing the compounds or pharmaceutical compositions containing the same. The compounds and pharmaceutical compositions of the present invention are provided for use in the treatment of HIV infection and/or AIDS.

Sphingosine 1 Phosphate Receptor Modulators And Methods Of Chiral Synthesis
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US Patent:

20110178056, Jul 21, 2011
Filed:

Nov 15, 2010
Appl. No.:

12/946800
Inventors:

Esther MARTINBOROUGH - San Diego CA, US
Marcus F. Boehm - San Diego CA, US
Adam Richard Yeager - San Diego CA, US
Junko Tamiya - Carlsbad CA, US
Liming Huang - San Diego CA, US
Enugurthi Brahmachary - San Diego CA, US
Manisha Moorjani - San Diego CA, US
International Classification:

A61K 31/4245
C07D 271/06
C07D 413/12
A61K 31/5377
A61K 31/454
A61P 25/00
A61P 37/06
A61P 11/00
A61P 1/00
A61P 1/04
A61P 31/16
US Classification:

51421018, 548131, 544138, 546209, 514364, 5142362, 514326
Abstract:

Compounds that selectively modulate the sphingosine 1 phosphate receptor are provided including compounds which modulate subtype 1 of the S1P receptor. Methods of chiral synthesis of such compounds is provided. Uses, methods of treatment or prevention and methods of preparing inventive compositions including inventive compounds are provided in connection with the treatment or prevention of diseases, malconditions, and disorders for which modulation of the sphingosine 1 phosphate receptor is medically indicated.

Novel Glp-1 Receptor Modulators
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US Patent:

20130178420, Jul 11, 2013
Filed:

Dec 12, 2012
Appl. No.:

13/712624
Inventors:

Esther Martinborough - San Diego CA, US
Manisha Moorjani - San Diego CA, US
Junko Tamiya - Carlsbad CA, US
Liming Huang - San Diego CA, US
Adam R. Yeager - La Mesa CA, US
Enugurthi Brahmachary - San Diego CA, US
Thomas Fowler - Melton Mowbray, GB
Andrew Novak - Nottingham, GB
Premji Meghani - Leicestershire, GB
Michael Knaggs - Burton-on-Trent, GB
Assignee:

RECEPTOS, INC. - San Diego CA
International Classification:

C07D 413/14
A61K 31/4245
C07D 413/10
A61K 31/454
A61K 31/4545
A61K 31/4709
C07D 239/26
A61K 31/505
C07D 413/12
A61K 31/506
C07D 403/12
C07D 403/04
C07D 243/08
A61K 31/551
A61K 38/26
C07D 271/06
US Classification:

514 117, 548131, 514364, 546209, 514326, 546194, 514318, 546166, 514314, 544335, 514256, 544333, 544296, 544295, 51425214, 540575, 514218, 435375
Abstract:

The invention relates to compounds that modulate the glucagon-like peptide 1 (GLP-1) receptor, methods of their synthesis, and methods of their therapeutic and/or prophylactic use. Such compounds are act as modulators or potentiators of GLP-1 receptor on their own, or with receptor ligands including GLP-1 peptides GLP-1(7-36) and GLP-1(9-36), or with peptide-based therapies, such as exenatide and liraglutide, and have the following general structure (where “” represents either or both the R and S form of the compound):where A, B, C, Y, Y, Z, R, R, R, R, R, W, n, p and q are as defined herein.

Sphingosine 1 Phosphate Receptor Modulators And Methods Of Chiral Synthesis
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US Patent:

20130196966, Aug 1, 2013
Filed:

Jan 14, 2013
Appl. No.:

13/740669
Inventors:

Marcus F. Boehm - San Diego CA, US
Adam Richard Yeager - La Mesa CA, US
Junko Tamiya - Carlsbad CA, US
Liming Huang - San Diego CA, US
Enugurthi Brahmachary - San Diego CA, US
Manisha Moorjani - San Diego CA, US
Assignee:

RECEPTOS, INC. - San Diego CA
International Classification:

C07D 271/06
A61K 45/06
A61K 31/454
A61K 31/5377
C07D 413/12
A61K 31/4245
US Classification:

51421018, 548131, 544138, 546209, 514364, 5142362, 514326, 564225, 558423
Abstract:

Compounds that selectively modulate the sphingosine 1 phosphate receptor are provided including compounds which modulate subtype 1 of the S1P receptor. Methods of chiral synthesis of such compounds are provided. Uses, methods of treatment or prevention and methods of preparing inventive compositions including inventive compounds are provided in connection with the treatment or prevention of diseases, malconditions, and disorders for which modulation of the sphingosine 1 phosphate receptor is medically indicated.

Selective Sphingosine 1 Phosphate Receptor Modulators And Methods Of Chiral Synthesis
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US Patent:

20130231326, Sep 5, 2013
Filed:

Jan 14, 2013
Appl. No.:

13/740661
Inventors:

Marcus F. Boehm - San Diego CA, US
Adam Richard Yeager - La Mesa CA, US
Junko Tamiya - Carlsbad CA, US
Liming Huang - San Diego CA, US
Enugurthi Brahmachary - San Diego CA, US
Manisha Moorjani - San Diego CA, US
Gregg Alan Timony - San Diego CA, US
Jennifer L. Brooks - Encinitas CA, US
Robert Peach - San Diego CA, US
Fiona Lorraine Scott - San Diego CA, US
Michael Allen Hanson - San Marcos CA, US
Assignee:

RECEPTOS, INC. - San Diego CA
International Classification:

C07D 271/06
A61K 31/496
A61K 31/454
A61K 31/4245
C07C 311/13
A61K 31/427
C07C 245/14
A61K 45/06
C07D 413/12
C07D 417/12
C07D 413/14
A61K 31/5377
C07C 255/58
US Classification:

51421018, 5142362, 51425403, 514326, 514364, 544138, 544367, 546209, 548131, 558413, 558418, 564246
Abstract:

Compounds that selectively modulate the sphingosine 1 phosphate receptor are provided including compounds which modulate subtype 1 of the S1P receptor. Methods of chiral synthesis of such compounds are provided. Uses, methods of treatment or prevention and methods of preparing inventive compositions including inventive compounds are provided in connection with the treatment or prevention of diseases, malconditions, and disorders for which modulation of the sphingosine 1 phosphate receptor is medically indicated.

Selective Heterocyclic Sphingosine 1 Phosphate Receptor Modulators
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US Patent:

20140039183, Feb 6, 2014
Filed:

Jul 15, 2013
Appl. No.:

13/941695
Inventors:

Esther Martinborough - San Diego CA, US
Enugurthi Brahmachary - San Diego CA, US
Manisha Moorjani - San Diego CA, US
Junko Tamiya - Carlsbad CA, US
Liming Huang - San Diego CA, US
Adam Richard Yeager - La Mesa CA, US
International Classification:

C07D 333/24
C07D 413/12
C07D 277/30
C07D 285/12
US Classification:

544134, 548136, 546209, 548205, 544369, 544133, 549 75
Abstract:

Compounds that selectively modulate the sphingosine 1 phosphate receptor are provided including compounds which modulate subtype 1 of the S1P receptor. Methods of chiral synthesis of such compounds are provided. Uses, methods of treatment or prevention and methods of preparing inventive compositions including inventive compounds are provided in connection with the treatment or prevention of diseases, malconditions, and disorders for which modulation of the sphingosine 1 phosphate receptor is medically indicated.

Resumes

Manager, Api Development And Manufacturing

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Location:

San Diego, CA

Industry:

Biotechnology

Work:

Celgene
Manager, Api Development and Manufacturing
Receptos, A Wholly-Owned Subsidiary of Celgene May 2009 - Nov 2016
Scientist Iii
Receptos, A Wholly-Owned Subsidiary of Celgene Feb 2008 - Apr 2009
Scientist Ii
Vertex Pharmaceuticals Mar 2007 - Feb 2008
Research Scientist, Medicinal Chemistry
Chembridge Research Laboratories Jan 2003 - Jan 2007
Research Scientist

Education:

University of California, Berkeley 2000 - 2003
Indian Institute of Technology, Bombay 1994 - 1999
P.g. College of Law, Basheerbagh 1992 - 1994

Skills:

Medicinal Chemistry
Drug Discovery
Drug Design
Organic Synthesis
Organic Chemistry
Pharmaceutical Industry
Biotechnology
Lead Change
Nmr
Lc Ms
Cro
Drug Development
Heterocyclic Chemistry
Synthetic Organic Chemistry
High Throughput Screening
Mass Spectrometry
Chromatography
Nmr Spectroscopy
Peptides
Molecular Modeling
Chiral Chromatography
Pharmacokinetics
Drug Metabolism
Manufacturing
Process Chemistry

Languages:

Hindi
Telugu

Certifications:

Emtrain
Preventing Workplace Harassment

Enugurthi Brahmachary

Enugurthi Brahmachary Phones & Addresses

Work

Education

Skills

Languages

Ranks

Industries

Us Patents

Selective Sphingosine 1 Phosphate Receptor Modulators And Methods Of Chiral Synthesis

Selective Heterocyclic Sphingosine 1 Phosphate Receptor Modulators

Piperazine And Piperidine Biaryl Derivatives

Sphingosine 1 Phosphate Receptor Modulators And Methods Of Chiral Synthesis

Novel Glp-1 Receptor Modulators