Enzo M Caruso

from Allston, MA

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Enzo Caruso Phones & Addresses

36 Ridgemont St #2, Allston, MA 02134

Us Patents

Bonding Of Cartilaginous Matrices Using Isolated Chondrocytes
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US Patent:

20010006634, Jul 5, 2001
Filed:

Feb 6, 2001
Appl. No.:

09/777790
Inventors:

David Zaleske - Weston MA, US
Giuseppe Peretti - Milan, IT
Enzo Caruso - Allston MA, US
Francesco Rossetti - Milan, IT
Mark Randolph - Chelmsford MA, US
Assignee:

The General Hospital Corporation
International Classification:

A01N063/00
US Classification:

424/093700, 435/325000
Abstract:

Methods of bonding cartilage pieces using new cartilage matrix generated by isolated chondrocytes in the presence of a biological gel. Also featured in the invention are cartilage implants used to repair cartilage defects.

Bonding Of Cartilaginous Matrices Using Isolated Chondrocytes
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US Patent:

20030099620, May 29, 2003
Filed:

Oct 16, 2002
Appl. No.:

10/272189
Inventors:

David Zaleske - Weston MA, US
Giuseppe Peretti - Milan, IT
Enzo Caruso - Allston MA, US
Francesco Rossetti - Milan, IT
Mark Randolph - Chelmsford MA, US
Assignee:

The general Hospital Corporation
International Classification:

A61K045/00
US Classification:

424/093700, 424/426000
Abstract:

Methods of bonding cartilage pieces using new cartilage matrix generated by isolated chondrocytes in the presence of a biological gel. Also featured in the invention are cartilage implants used to repair cartilage defects.

Bonding Of Cartilage Pieces Using Isolated Chondrocytes And A Biological Gel
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US Patent:

61837377, Feb 6, 2001
Filed:

Oct 29, 1998
Appl. No.:

9/182379
Inventors:

David J. Zaleske - Weston MA
Giuseppe Peretti - Milan, IT
Enzo Caruso - Allston MA
Francesco Rossetti - Milan, IT
Mark Randolph - Chelmsford MA
Assignee:

The General Hospital Corporation - Boston MA
International Classification:

A61F 200
A01N 100
C12N 500
C12N 1104
C12N 1102
US Classification:

424 937
Abstract:

Isolated chondrocytes are propagated in the presence of a biological gel such as a fibrin gel to generate a cartilage matrix that firmly bonds together two adjacent cartilage pieces. A bonding composition containing the isolated chondrocytes mixed with the biological gel is applied to a surface of one (or both) of the cartilage pieces, and the surface is contacted with the other cartilage piece. In a different order of steps, the two cartilage pieces are held in apposition, and gaps at the interface are filled with the bonding composition. In another method, either or both of the cartilage pieces are first incubated with the isolated chondrocytes, the biological gel is then applied, and the cartilage pieces are held together. Alternatively, after incubating with isolated chondrocytes, the biological gel can be applied to fill gaps at the interface between cartilage pieces held in apposition. One or both of the cartilage pieces can be depleted of endogenous chondrocytes before bonding, and the cartilage pieces can be articular cartilage, fibrocartilage or growth cartilage.