Jeonghan Park - Whippany NJ, US Anantha Sudhakar - East Brunswick NJ, US George S. Wong - Summit NJ, US Minzhang Chen - Plainsboro NJ, US Juergen Weber - East Windsor NJ, US Xiaojing Yang - Waterford CT, US Ingyu Jeon - Fanwood NJ, US Ramani R. Raghavan - Edison NJ, US Maria Tamarez - Rahway NJ, US Weidong Tong - Mountainside NJ, US Eugene J. Vater - Lyndhurst NJ, US
Assignee:
Schering Corporation - Kenilworth NJ
International Classification:
A61K 31/21 C07D 209/52
US Classification:
514412, 548452
Abstract:
In one embodiment, the present application relates to a process of making a compound of formula I.
Process And Intermediates For The Preparation Of (1R,2S,5S)-6,6-Dimethyl-3-Azabicyclo[3,1,0]Hexane-2-Carboxylates For Salts Thereof
Jeonghan Park - Whippany NJ, US Anantha R Sudhakar - Fremont CA, US George S. K. Wong - Summit NJ, US Minzhang Chen - Plainsboro NJ, US Juergen Weber - East Windsor NJ, US Xiaojing Yang - Waterford CT, US Ingyu Jeon - Fanwood NJ, US Ramani R Raghavan - Lexington MA, US Maria Tamarez - Rahway NJ, US Weidong Tong - Mountainside NJ, US Eugene J. Vater - Lyndhurst NJ, US
Assignee:
Schering Corporation - Kenilworth NJ
International Classification:
C07D 209/52
US Classification:
548515
Abstract:
In one embodiment, the present application relates to a process of making a compound of formula I.
Process And Intermediates For The Preparation Of (1,2,5)-6,6-Dimethyl-3-Azabicyclo[3,1,0]Hexane-2-Carboxylates Or Salts Thereof
Jeonghan Park - Whippany NJ, US Anantha R Sudhakar - Fremont CA, US George S. K. Wong - Summit NJ, US Minzhang Chen - Plainsboro NJ, US Juergen Weber - East Windsor NJ, US Xiaojing Yang - Waterford CT, US Ingyu Jeon - Fanwood NJ, US Ramani R Raghavan - Lexington MA, US Maria Tamarez - Rahway NJ, US Weidong Tong - Mountainside NJ, US Eugene J. Vater - Lyndhurst NJ, US
Assignee:
Schering Plough Corporation - Kenilworth NJ
International Classification:
C07C 69/01 C07C 211/17 C07C 235/02
US Classification:
560124, 564182, 564455
Abstract:
In one embodiment, the present application relates to a process of making a compound of formula I.
Process For The Synthesis Of 3-Amino-3-Cyclobuthylmethyl-2-Hydroxypropionamide Or Salts Thereof
Jeonghan Park - Whippany NJ, US Eugene J. Vater - Lyndhurst NJ, US Shuan Dong - Watchung NJ, US Tetsuo Iwama - Scotch Plains NJ, US Ramani R. Raghavan - Lexington MA, US Hong-Chang Lee - Livingston NJ, US George S.k. Wong - Summit NJ, US
Disclosed is a process for preparing 3-(amino)-3-cyclobutylmethyl-2-hydroxy-propionamide hydrochloride, an intermediate useful in the preparation of the HCV protease inhibitor (1R,5S)—N-[3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]-3-[2(S)-[[[(1,1-dimethylethyl)amino]carbonyl]amino]-3,3-dimethyl-1-oxobutyl]-6,6-dimethyl-3-azabicyclo[3.1.0]hexan-2(S)-carboxamide.
Process For Preparation Of 9.Alpha. -Chloro-11.Beta. Formyloxypregna-3.20-Diones
Richard W. Draper - North Caldwell NJ Eugene J. Vater - Lyndhurst NJ
Assignee:
Schering Corporation - Kenilworth NJ
International Classification:
C07J 500 C07J 700 C07J 4300 C07J 3300
US Classification:
552574
Abstract:
Disclosed is a process for producing a compound of the formula: ##STR1## by reacting a compound of the formula: ##STR2## with: (1) a chlorinating reagent selected from an N-chloroimide or an N-chloroamide; (2) an anhydrous strong acid selected from orthophosphoric acid, alkylsulfonic acids, fluoroalkylsulfonic acids or arylsulfonic acids; and (3) anhydrous dimethylformamide; at a temperature within the range of about -78. degree. to about 0. degree. C.
Richard W. Draper - North Caldwell NJ Radha V. Iyer - Edison NJ Yuelie Lu - Thousand Oaks CA Eugene J. Vater - Lyndhurst NJ
Assignee:
Schering Corporation - Kenilworth NJ
International Classification:
C07D40510 C07D40512
US Classification:
546196
Abstract:
A short practical commercial process for the efficient enantioselective synthesis of the non-steroidal antiestrogen of formula I or XIV ##STR1## or a pharmaceutically acceptable salt thereof.
Process For Preparation Of 9.Alpha.-Chloro-11.Beta.-Formyloxypregna-3,20-Diones
Richard W. Draper - North Caldwell NJ Eugene J. Vater - Lyndhurst NJ
Assignee:
Schering Corporation - Kenilworth NJ
International Classification:
C07J 7500
US Classification:
540 61
Abstract:
Disclosed is a process for producing a compound of the formula: ##STR1## by reacting a compound of the formula: ##STR2## with: (1) a chlorinating reagent selected from an N-chloroimide or an N-chloroamide; (2) an anhydrous strong acid selected from orthophosphoric acid, alkylsulfonic acids, fluoroalkylsulfonic acids or arylsulfonic acids; and (3) anhydrous dimethyl formamide; at a temperature within the range of about -78. degree. to about 0. degree. C. , under anhydrous conditions under an inert atmosphere.
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