Eugene J Vidunas

US Patent:

20040082764, Apr 29, 2004

Filed:

May 2, 2003

Appl. No.:

10/428894

Inventors:

Arthur Kunz - New City NY, US
Justin Moran - Valley Cottage NY, US
Joseph Rubino - Towaco NJ, US
Neera Jain - New City NY, US
Eugene Vidunas - Middletown NY, US
John Simpson - Upper Nyack NY, US
Paul Robbins - Upper Nyack NY, US
Nishith Merchant - Palisades Park NJ, US
John DiJoseph - Woodbridge NJ, US
Mark Ruppen - Garnerville NY, US
Nitin Damle - Upper Saddle River NJ, US
Andrew Popplewell - Staines, GB

Assignee:

Wyeth Holdings Corporation - Madison NJ

International Classification:

C07K016/46
C07K014/47

US Classification:

530/391100, 530/409000

Abstract:

Methods for preparing monomeric cytotoxic drug/carrier conjugates with a drug loading significantly higher than in previously reported procedures and with decreased aggregation and low conjugate fraction (LCF) are described. Cytotoxic drug derivative/antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described. Monomeric calicheamicin derivative/anti-CD22 antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described.

US Patent:

20040192900, Sep 30, 2004

Filed:

Nov 3, 2003

Appl. No.:

10/699874

Inventors:

Arthur Kunz - New City NY, US
Justin Moran - Valley Cottage NY, US
Joseph Rubino - Towaco NJ, US
Neera Jain - New City NY, US
Eugene Vidunas - Middletown NY, US
John Simpson - Upper Nyack NY, US
Nishith Merchant - Palisades Park NJ, US
John DiJoseph - Woodbridge NJ, US
Mark Ruppen - Garnerville NY, US
Nitin Damle - Upper Saddle River NJ, US
Paul Robbins - Derwood MD, US
Andrew Popplewell - Staines, GB

Assignee:

Wyeth Holdings Corporation - Madison NJ

International Classification:

C07K016/46
C07K014/47

US Classification:

530/391100, 530/403000, 530/409000

Abstract:

Methods for preparing monomeric cytotoxic drug/carrier conjugates with a drug loading significantly higher than in previously reported procedures and with decreased aggregation and low conjugate fraction (LCF) are described. Cytotoxic drug derivative/antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described. Monomeric calicheamicin derivative/anti-CD22 antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described.

US Patent:

20060002942, Jan 5, 2006

Filed:

Mar 15, 2005

Appl. No.:

11/080587

Inventors:

Arthur Kunz - New City NY, US
Justin Moran - Valley Cottage NY, US
Joseph Rubino - Towaco NJ, US
Neera Jain - Monroe NY, US
Erwin Raymond Boghaert - Monroe NY, US
Philip Hamann - Thiells NY, US
Mark Ruppen - Garnerville NY, US
Nitin Damle - Upper Saddle River NJ, US
Eugene Vidunas - Middletown NY, US

Assignee:

Wyeth - Madison NJ

International Classification:

A61K 39/395
C07K 16/46

US Classification:

424178100, 530391100

Abstract:

Anti-Lewis Y antibodies are described. Methods for preparing monomeric cytotoxic drug/carrier conjugates with a drug loading significantly higher than in previously reported procedures and with decreased aggregation and low conjugate fraction (LCF) are described. Cytotoxic drug derivative/antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described. Specifically, monomeric calicheamicin derivative/anti-Lewis Y antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described.

US Patent:

20070213511, Sep 13, 2007

Filed:

Mar 15, 2005

Appl. No.:

10/592438

Inventors:

Arthur Kunz - New City NY, US
Philip Hamann - Thiells NY, US
Justin Moran - Valley Cottage NY, US
Eugene Vidunas - Middletown NY, US

Assignee:

Wyeth - Madison NJ

International Classification:

C07K 16/46

US Classification:

530391100

Abstract:

The present invention provides processed for preparing a calicheamicin conjugate comprising removing glycosylation of a protein and reacting (i) an activated calicheamicin—hydrolyzable linker derivative and (ii) the deglycosylated protein. In one embodiment, the protein is an antibody, such as an anti-CD33 antibody (e.g., hp67.6), an anti-CD22 antibody (e.g., G544), an anti-Lewis Y antibody (e.g., G193), an anti-5T4 antibody (e.g., H8) or an anti-CD20 antibody (e.g., rituximab). In another embodiment, the calicheamicin derivative is an N-acyl derivative of calicheamicin or a disulfide analog of calicheamicin, such as N-acetyl gamma calicheamicin dimethyl hydrazide (N-acetyl calicheamicin DMH) and the hydrolyzable linker is 4-(4-acetylephenoxy) butanoic acid (AcBut) or (3-Acetylphenyl) acetic acid (AcPAc). Also provided are calicheamicin conjugates produced by such processes.

US Patent:

20090105461, Apr 23, 2009

Filed:

Aug 4, 2008

Appl. No.:

12/221551

Inventors:

Arthur Kunz - New City NY, US
Justin Keith Moran - Valley Cottage NY, US
Joseph Thomas Rubino - Towaco NJ, US
Neera Jain - Lexington MA, US
Erwin Raymond Arsene Boghaert - Monroe NY, US
Philip Ross Hamann - Thiells NY, US
Mark Edward Ruppen - Garnerville NY, US
Nitin Krishnaji Damle - Upper Saddle River NJ, US
Eugene Vidunas - Middletown NY, US
Lyka Kalyandrug - Congers NY, US

Assignee:

Wyeth - Madison NJ

International Classification:

C07K 16/00

US Classification:

5303919

Abstract:

Anti-Lewis Y antibodies are described. Methods for preparing monomeric cytotoxic drug/carrier conjugates with a drug loading significantly higher than in previously reported procedures and with decreased aggregation and low conjugate fraction (LCF) are described. Cytotoxic drug derivative/antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described. Specifically, monomeric calicheamicin derivative/anti-Lewis Y antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described.

US Patent:

20100028952, Feb 4, 2010

Filed:

Jun 21, 2007

Appl. No.:

12/305428

Inventors:

Eugene Joseph Vidunas - Middletown NY, US
Gow-Jen Tsai - Airmont NY, US
Ping Cai - New City NY, US
Justin Moran - Valley Cottage NY, US
Pamela Sue Fink - New City NY, US
Lourdes Jeanette Gordon - White Plains NY, US

Assignee:

WYETH - Madison NJ

International Classification:

C12P 21/00
C12N 1/20
C07K 1/00

US Classification:

435 712, 4352526, 530416

Abstract:

The present invention provides methods for production and purification of active chromoproteins produced by sp. 21G792. The chromoproteins are useful for developing pharmaceutical compositions and treating diseases such as cancer or bacterial infections.

US Patent:

20120213804, Aug 23, 2012

Filed:

Feb 13, 2012

Appl. No.:

13/372172

Inventors:

ARTHUR KUNZ - New City NY, US
Justin Keith Moran - Valley Cottage NY, US
Joseph Thomas Rubino - Towace NJ, US
Neera Jain - New City NY, US
Eugene Joseph Vidunas - Middletown NY, US
John McLean Simpson - Upper Nyack NY, US
Paul David Robbins - Upper Nyack NY, US
Nishith Merchant - Palisades Park NJ, US
John Francis Dijoseph - Woodbridge NJ, US
Mark Edward Ruppen - Garnerville NY, US
Nitin Krishnaji Damle - Upper Saddle River NJ, US
Andrew George Popplewell - Staines, GB

Assignee:

WYETH HOLDINGS CORPORATION - Madison NJ

International Classification:

A61K 39/44
A61P 35/00
A61P 29/00
C07K 17/10

US Classification:

4241811, 5303919

Abstract:

Methods for preparing monomeric cytotoxic drug/carrier conjugates with a drug loading significantly higher than in previously reported procedures and with decreased aggregation and low conjugate fraction (LCF) are described. Cytotoxic drug derivative/antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described. Monomeric calicheamicin derivative/anti-CD22 antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described.

US Patent:

20180339058, Nov 29, 2018

Filed:

Jul 30, 2018

Appl. No.:

16/048511

Inventors:

- New York NY, US
Justin Keith Moran - Valley Cottage NY, US
Joseph Thomas Rubino - Towaco NJ, US
Neera Jain - New City NY, US
Eugene Joseph Vidunas - Middletown NY, US
John McLean Simpson - Upper Nyack NY, US
Nishith Merchant - Palisades Park NJ, US
John Francis Dijoseph - Woodbridge NJ, US
Mark Edward Ruppen - Garnerville NY, US
Nitin Krishnaji Damle - Upper Saddle River NJ, US
Paul David Robbins - Drewood MD, US
Andrew George Popplewell - Staines, GB

Assignee:

Wyeth Holdings LLC - New York NY

International Classification:

A61K 47/64
C07K 16/28
A61K 47/68

Abstract:

Methods for preparing monomeric cytotoxic drug/carrier conjugates with a drug loading significantly higher than in previously reported procedures and with decreased aggregation and low conjugate fraction (LCF) are described. Cytotoxic drug derivative/antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described. Monomeric calicheamicin derivative/anti-CD22 antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described.