Eugene Leroy Wittle from 1200 Earhart Rd, Ann Arbor, MI 48105, Phone: 7346639444

Nonapeptides And Methods For Their Production
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US Patent:

40862194, Apr 25, 1978
Filed:

Dec 27, 1976
Appl. No.:

5/754785
Inventors:

Eugene Leroy Wittle - Ann Arbor MI
Mildred Catherine Rebstock - Ann Arbor MI
Assignee:

Parke, Davis & Company - Detroit MI
International Classification:

C07C10352
A61K 3700
US Classification:

2601125LH
Abstract:

New nonapeptides having the formula Prot Grp-R-Trp-Ser-Tyr-R. sub. 2 -Leu-Arg-Pro-Gly-R. sub. 3 ; salts thereof; wherein R is Gln, Gln (bzl), His (bzl), Ser (bzl), Pro, Leu, Tyr (bzl), Ile, Cys (bzl) or Phe, R. sub. 2 is D-Phe, D-Ala, D-Leu, D-Trp, D-Tyr, D-Tyr (Me), D-Ser, D-Met, D-Arg, D-Val, D-His, D-Gln, D-Phs, D-Thr, D-Pro or D-Asn and R. sub. 3 is NH. sub. 2, NH(lower alkyl) or N-(lower alkyl). sub. 2, methods for their production; certain peptide intermediates and their salts used in the production thereof; and the use of said nonapeptides as luteinizing hormone releasing factor antagonists.

Octapeptides And Methods For Their Production
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US Patent:

41119231, Sep 5, 1978
Filed:

Dec 27, 1976
Appl. No.:

5/754468
Inventors:

Eugene Leroy Wittle - Ann Arbor MI
Mildred Catherine Rebstock - Ann Arbor MI
Ernest D. Nicolaides - Ann Arbor MI
Alfred Campbell - Ann Arbor MI
Assignee:

Parke, Davis & Company - Detroit MI
International Classification:

C07C10352
A61K 3702
US Classification:

2601125R
Abstract:

New octapeptides having the formula Prot Grp-R-Trp-Ser-Tyr-R. sub. 2 -Leu-Arg-Pro-R. sub. 3 ; salts thereof; wherein R is Gln, Gln (bzl), His (bzl), Ser (bzl), Pro, Leu, Tyr (bzl), Ile, Cys (bzl) or Phe, R. sub. 2 is D-Phe, D-Ala, D-Leu, D-Trp, D-Tyr, D-Tyr (Me), D-Ser, D-Met, D-Arg, D-Val, D-His, D-Gln, D-Phs, D-Thr, D-Pro, D-Me. sub. 5 Phe or D-Asn and R. sub. 3 is NH. sub. 2, NH(lower alkyl), N-(lower alkyl). sub. 2, NH-benzyl, NHCH. sub. 2 CH. sub. 2 N-(lower alkyl). sub. 2 or NH-CH. sub. 2 CH. sub. 2 SO. sub. 2 NH-benzyl; methods for their production; certain peptide intermediates and their salts used in the production thereof; and the use of said octapeptides as luteinizing hormone releasing factor antagonists.

Pyroglutamyl-Histidyl-Tryptophanyl-Seryl-Tyrosyl Hydrazides
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US Patent:

41285409, Dec 5, 1978
Filed:

May 25, 1972
Appl. No.:

5/257000
Inventors:

Mildred C. Rebstock - Ann Arbor MI
Ernest D. Nicolaides - Ann Arbor MI
Thomas F. Mick - Ann Arbor MI
Francis J. Tinney - Ann Arbor MI
Eugene L. Wittle - Ann Arbor MI
Assignee:

Parke, Davis & Company - Detroit MI
International Classification:

C07C10352
US Classification:

2601125R
Abstract:

A new decapeptide having the formula, pGlu-His-Trp-Ser-Tyr-Gly-Leu-NO. sub. 2 Arg-Pro-Gly(NH. sub. 2); salts thereof; production thereof by reacting pGlu-His-Trp-Ser-Tyr(N. sub. 3) with Gly-Leu-NO. sub. 2 Arg-Pro-Gly(NH. sub. 2), by reacting pGlu-His-Trp-Ser-Tyr-Gly(N. sub. 3) with Leu-NO. sub. 2 Arg-Pro-Gly(NH. sub. 2), or by reacting pGlu-His-Trp-Ser-Tyr-Gly-Leu(N. sub. 3) with NO. sub. 2 Arg-Pro-Gly(NH. sub. 2); certain peptide intermediates and their salts used in the production thereof; and the use thereof in the preparation of luteinizing hormone releasing factor.

Hexapeptides And Methods For Their Production
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US Patent:

40874184, May 2, 1978
Filed:

Sep 15, 1976
Appl. No.:

5/723425
Inventors:

Eugene Leroy Wittle - Ann Arbor MI
Assignee:

Parke, Davis & Company - Detroit MI
International Classification:

C07C10352
A61K 3700
US Classification:

2601125LH
Abstract:

New hexapeptides having the formula X-Ser(benzyl)-Tyr(benzyl)-Ala-Leu-Arg-Pro-Y wherein X is t-butoxycarbonyl or benzyloxycarbonyl and Y is lower alkoxy, amino, lower alkylamino or di(lower alkyl)amino.

Tetrapeptides
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US Patent:

40310710, Jun 21, 1977
Filed:

Mar 1, 1976
Appl. No.:

5/662406
Inventors:

Eugene Leroy Wittle - Ann Arbor MI
Ernest D. Nicolaides - Ann Arbor MI
Assignee:

Parke, Davis & Company - Detroit MI
International Classification:

C07C10352
US Classification:

2601125LH
Abstract:

New tetrapeptides having the formula A-Ser(benzyl)-Try(benzyl)-D-Ala-Leu-R. sub. 1 wherein A is t-butoxycarbonyl, cyclohexylcarbonyl, benzyloxycarbonyl and p-nitrobenzyloxycarbonyl; Ser(benzyl) is D-Ser(benzyl) or L-Ser(benzyl); Tyr(benzyl) is D-Tyr(benzyl) or L-Tyr(benzyl); Leu is D-Leu or L-Leu, and R. sub. 1 is lower alkoxy, hydrazino, amino, lower alkylamino or di(lower alkyl)amino.

New Pentapeptides And Methods For Their Production
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US Patent:

40439941, Aug 23, 1977
Filed:

Jun 23, 1976
Appl. No.:

5/699125
Inventors:

Eugene Leroy Wittle - Ann Arbor MI
Ernest D. Nicolaides - Ann Arbor MI
Marland Paul Hutt - Saline MI
Assignee:

Parke, Davis & Company - Detroit MI
International Classification:

C07C10352
US Classification:

2601125LH
Abstract:

New pentapeptides having the formula X-R-Ser-(benzyl)-Tyr(benzyl)-R. sup. 1 -Y wherein X is t-butoxycarbonyl or benzyloxycarbonyl, R is a single amino acid fragment or a dipeptide fragment utilizing amino acids selected from the group consisting of Aze, His(benzyl) and Trp; R. sup. 1 is a single amino acid fragment or a dipeptide fragment utilizing amino acids selected from the group consisting of Ala, Leu and Pro and Y is lower alkoxy, hydrazino, amino, lower alkylamino or di(lower alkyl)amino with the priviso that the total number of amino acid units when R and R. sup. 1 are combined is three.

Eugene Leroy Wittle