Francis Rodier

US Patent:

20180139939, May 24, 2018

Filed:

Jan 12, 2018

Appl. No.:

15/870172

Inventors:

- Novato CA, US
Francis Rodier - Novato CA, US
Judith Campisi - Berkeley CA, US

International Classification:

A01K 67/027
A61K 49/00
C12N 15/85

Abstract:

This disclosure provides non-human animal models for age-related disorders and age-sensitive traits, particularly those caused by senescence-inducing stimuli, wherein the models comprise transgenes selectively expressed by senescent cells. The disclosure further provides methods for identifying therapeutic agents effective for treating or preventing age-related disorders and age-sensitive traits using the animal models, therapeutic agents identified using such methods, pharmaceutical compositions comprising the identified therapeutic agents, and methods of treating or preventing age-related disorders and age-sensitive traits.