Franck Y Lemiale

US Patent:

20110142880, Jun 16, 2011

Filed:

Mar 27, 2009

Appl. No.:

12/934987

Inventors:

Franck Yann Lemiale - North Potomac MD, US
Nikolay Korokhov - Germantown MD, US
Laurent M. Humeau - Germantown MD, US
Vladimir Slepushkin - Damascus MD, US

International Classification:

A61K 39/21
C12N 15/63
C12N 15/867
A61K 31/7088
C12N 5/10
A61P 37/04
A61P 35/00
A61P 25/28
A61P 9/00
A61P 25/00
A61P 3/00
A61P 19/02

US Classification:

4242071, 4353201, 435455, 514 44 R, 435325

Abstract:

The present invention provides for lentiviral vectors for vaccine delivery comprising a 5′ long terminal repeat (LTR) and a 3′ LTR, an integrated nucleic acid sequence, wherein the integrated nucleic acid sequence is expressed by the 5′ LTR; and a nucleic acid sequence encoding functional REV coding sequence and a rev response element (RRE)-containing sequence, wherein the RRE-containing sequence is located upstream of the REV coding sequence, and wherein transcription of said first nucleic acid sequence and said second nucleic acid sequence is driven by said 5′ LTR. Also provided for are pharmaceutical compositions, methods of making and using the lentiviral vectors of the present invention.

US Patent:

20070036783, Feb 15, 2007

Filed:

Jun 16, 2006

Appl. No.:

11/424637

Inventors:

Laurent Humeau - Germantown MD, US
Brian Paszkiet - Frederick MD, US
Franck Lemiale - North Potomac MD, US

Assignee:

VIRxSYS, Corporation - Gaithersburg MD

International Classification:

A61K 39/395
C07K 16/28
C07K 16/46

US Classification:

424143100, 530388220, 530391100

Abstract:

This invention is directed to a soluble complex of ligands that binds to surface molecules of hemopoietic cells and result in their activation or expansion. The complex may be used in the activation and/or expansion of hemopoietic cells, optionally in combination with their transduction. The complex of ligands bind at least two cell surface molecules, such as one that plays a role in cell-cell adhesion and one that may or may not activate or stimulate the cell to promote growth and/or proliferation after binding to a ligand. A complex of ligands that bind two hemopoietic cell stimulatory molecules is also provided. The invention further provides for the use of the complex to target vectors to hemopoietic cells.