Gary V Desir

US Patent:

7700095, Apr 20, 2010

Filed:

Mar 21, 2005

Appl. No.:

10/593099

Inventors:

Jianchao Xu - Bethany CT, US
Gary Desir - Woodbridge CT, US

Assignee:

Yale University - New Haven CT

International Classification:

A61K 38/44
C12N 9/02
C12Q 1/00
C12P 21/04
C12N 1/20
C07H 21/04
C12Q 1/68

US Classification:

424 944, 435189, 435 4, 435 6, 435 691, 435 711, 4352523, 4353201, 435440, 536 232

Abstract:

The present invention provides for the identification, isolation and uses of mammalian Monoamine Oxidase C (MAO-C), also known as renalase.

US Patent:

7858084, Dec 28, 2010

Filed:

Nov 21, 2006

Appl. No.:

11/602409

Inventors:

Gary Desir - Woodbridge CT, US
Jianchao Xu - Bethany CT, US

Assignee:

Yale University - New Haven CT

International Classification:

A61K 38/44

US Classification:

424 944, 435189, 536 232

Abstract:

The present invention provides methods of using Monoamine Oxidase C (MAO-C), also known as renalase, as a therapeutic protein in its active and inactive forms. Administering inactive renalase protein to individuals with lower renalase levels can be used to provide them with an adequate pool of the protein that can be activated by the body as needed. Active renalase protein can be administered to individuals needing an immediate reduction of catecholamine levels. An inhibitor of renalase may be used to enhance adrenergic action.

US Patent:

7932067, Apr 26, 2011

Filed:

Jan 28, 2010

Appl. No.:

12/695843

Inventors:

Jianchao Xu - Bethany CT, US
Gary Desir - Woodbridge CT, US

Assignee:

Yale University - New Haven CT

International Classification:

C12N 9/02
C12N 15/00
C12N 1/20
C07H 21/04
C12P 21/04
C12Q 1/00
C12Q 1/68

US Classification:

435189, 435 4, 435 6, 435 691, 435 711, 4352523, 4353201, 435440, 536 232

Abstract:

The present invention provides for the identification, isolation and uses of mammalian Monoamine Oxidase C (MAO-C), also known as renalase.

US Patent:

20030032595, Feb 13, 2003

Filed:

Jun 11, 2002

Appl. No.:

10/167528

Inventors:

Gary Desir - Woodbridge CT, US
Jianchao Xu - Bethany CT, US

International Classification:

A61K048/00
A61K038/17
A61K031/47
A61K031/445
A61K031/44

US Classification:

514/012000, 514/044000, 514/019000, 514/307000, 514/313000, 514/352000, 514/355000, 514/317000, 514/419000, 514/642000

Abstract:

The present invention relates to weight control, control of body fat and food intake, and provides useful methods for treating, inter alia, obesity, diabetes and insulin insensitivity, and conditions, diseases, and disorders relating thereto. The invention also relates to methods of identifying useful compounds relating to weight loss, food intake, diabetes, and obesity, among other things, based on the discovery that inhibiting Kv1.3 activity mediates decreased food intake, weight loss, decreased body fat, increase glucose uptake, and increased insulin sensitivity, among other things.

US Patent:

20110081421, Apr 7, 2011

Filed:

Nov 15, 2010

Appl. No.:

12/946630

Inventors:

GARY DESIR - WOODBRIDGE CT, US
JIANCHAO XU - BETHANY CT, US

Assignee:

YALE UNIVERSITY - NEW HAVEN CT

International Classification:

A61K 38/44
A61K 9/14
A61P 9/00
A61P 25/00
C12N 9/02

US Classification:

424499, 424 944, 435189

Abstract:

The present invention provides methods of using Monoamine Oxidase C (MAO-C), also known as renalase, as a therapeutic protein in its active and inactive forms. Administering inactive renalase protein to individuals with lower renalase levels can be used to provide them with an adequate pool of the protein that can be activated by the body as needed. Active renalase protein can be administered to individuals needing an immediate reduction of catecholamine levels. An inhibitor of renalase may be used to enhance adrenergic action.

US Patent:

20130273023, Oct 17, 2013

Filed:

Apr 21, 2011

Appl. No.:

13/091359

Inventors:

JIANCHAO XU - BETHANY CT, US
GARY DESIR - WOODBRIDGE CT, US

Assignee:

YALE UNIVERSITY - NEW HAVEN CT

International Classification:

C12N 9/00

US Classification:

424 944, 435191, 435 74

Abstract:

The present invention provides for the identification, isolation and uses of mammalian Monoamine Oxidase C (MAO-C), also known as renalase.

US Patent:

20210355235, Nov 18, 2021

Filed:

Mar 8, 2018

Appl. No.:

16/491647

Inventors:

- New Haven CT, US
Gary Desir - Woodbridge CT, US

International Classification:

C07K 16/40
A61P 35/00
A61P 35/02
A61P 35/04
C07K 16/28
A61K 39/395

Abstract:

The invention provides compositions and methods for binding and inhibiting renalase. In one embodiment, the renalase binding molecule inhibits renalase activity. Thus, in diseases and conditions where a reduction of renalase activity is beneficial, such inhibitory renalase binding molecules act as therapeutics.

US Patent:

20190382736, Dec 19, 2019

Filed:

Jun 27, 2019

Appl. No.:

16/454223

Inventors:

- New Haven CT, US
Gary Desir - Woodbridge CT, US

International Classification:

C12N 9/02
C12Q 1/26

Abstract:

The present invention includes compositions and methods for detecting, treating and preventing renal and pancreatic diseases and disorders.