Ge E Dai

US Patent:

6803199, Oct 12, 2004

Filed:

Nov 26, 2001

Appl. No.:

09/995007

Inventors:

Nancy Carrasco - Bronx NY
Ge Dai - Bronx NY
Orlie Levy - Bronx NY

Assignee:

Albert Einstein College of Medicine of Yeshiva University - Bronx NY

International Classification:

C12Q 168

US Classification:

435 6, 435 71, 536 231, 536 235, 536 241, 536 243, 530300, 530350, 5303871

Abstract:

The present invention provides a purified and isolated nucleic acid encoding a sodium/iodide symporter. The present invention also provides purified sodium/iodide symporter, a vector comprising nucleic acid encoding sodium/iodide symporter, a host cell transformed with the vector, and a method for producing recombinant sodium/iodide symporter. In addition, the present invention provides nucleic acid probes and mixtures thereof specific for sodium/iodide symporter nucleic acid and antibodies immunoreactive with sodium/iodide symporter. The present invention also provides a method for diagnosing and treating thyroid disorders associated with non-functional sodium/iodide symporter. Furthermore, the present invention provides a method for the selective ablation of tissue. The present invention also provides a method for identifying an iodide transport protein in non-thyroid tissue. Finally, the present invention provides a non-human, transgenic model for a thyroid disorder.

US Patent:

7320863, Jan 22, 2008

Filed:

Sep 9, 2004

Appl. No.:

10/937239

Inventors:

Nancy Carrasco - Bronx NY, US
Ge Dai - Bronx NY, US
Orlie Levy - Bronx NY, US

Assignee:

Albert Einstein College of Medicine of Yeshiva University - Bronx NY

International Classification:

C12Q 1/68
C07H 21/02
C07H 21/04

US Classification:

435 6, 536 231, 536 243, 536 2431, 536 2433

Abstract:

The present invention provides a purified and isolated nucleic acid encoding a sodium/iodide symporter. The present invention also provides purified sodium/iodide symporter, a vector comprising nucleic acid encoding sodium/iodide symporter, a host cell transformed with the vector, and a method for producing recombinant sodium/iodide symporter. In addition, the present invention provides nucleic acid probes and mixtures thereof specific for sodium/iodide symporter nucleic acid and antibodies immunoreactive with sodium/iodide symporter. The present invention also provides a method for diagnosing and treating thyroid disorders associated with non-functional sodium/iodide symporter. Furthermore, the present invention provides a method for the selective ablation of tissue. The present invention also provides a method for identifying an iodide transport protein in non-thyroid tissue. Finally, the present invention provides a non-human, transgenic model for a thyroid disorder.

US Patent:

6391579, May 21, 2002

Filed:

Feb 1, 1996

Appl. No.:

08/595553

Inventors:

Nancy Carrasco - Bronx NY
Ge Dai - Bronx NY
Orlie Levy - Bronx NY

Assignee:

Albert Einstein College of Medicine of Yeshiva University - Bronx NY

International Classification:

C12P 2106

US Classification:

435 691, 4352523, 4353201, 536 231, 536 235, 536 243, 536 2431, 530350

Abstract:

The present invention provides a purified and isolated nucleic acid encoding a sodium/iodide symporter. The present invention also provides purified sodium/iodide symporter, a vector comprising nucleic acid encoding sodium/iodide symporter, a host cell transformed with the vector, and a method for producing recombinant sodium/iodide symporter. In addition, the present invention provides nucleic acid probes and mixtures thereof specific for sodium/iodide symporter nucleic acid and antibodies immunoreactive with sodium/iodide symporter. The present invention also provides a method for diagnosing and treating thyroid disorders associated with non-functional sodium/iodide symporter. Furthermore, the present invention provides a method for the selective ablation of tissue. The present invention also provides a method for identifying an iodide transport protein in non-thyroid tissue. Finally, the present invention provides a non-human, transgenic model for a thyroid disorder.