Dosage forms comprising pulse release formulations for oral administration of a Methylphenidate drug are provided. The dosage forms provide a substantially immediate dose of methylphenidate upon ingestion, followed by one or more additional doses at predetermined times. By providing such a drug release profile, the dosage forms eliminate the need for a patient to carry an additional dose for ingestion during the day. The dosage forms and methods provided are useful in administering Methylphenidate and pharmaceutically acceptable salts thereof, which generally require one or more doses throughout the day.
George R. Krsek - Tucson AZ, US Enrique E. Durazo - Oro Valley AZ, US
Assignee:
Konec, Inc. - Tucson AZ
International Classification:
B01D 15/08 A61K 31/445
US Classification:
210656, 514317, 546192
Abstract:
A method to resolve the stereoisomers of an optically active compound comprising an amine moiety. The method provides a mixture comprising two stereoisomers of a compound comprising a amine moiety. The method supplies l-fenchyloxyacetic acid, treats the mixture of stereoisomers with that l-fenchyloxyacetic acid, and collects one of those two stereoisomers having greater than a 99 percent enantiomeric excess.
Pain Relief Composition, Method To Form Same, And Method To Use Same
George R. Krsek - Tucson AZ, US Enrique E. Durazo - Oro Valley AZ, US
Assignee:
Konec, Inc. - Tucson AZ
International Classification:
A61K 9/28
US Classification:
424474
Abstract:
An oral dosage form which includes a bi-layer tablet consisting of an Actives Granulation layer and an Osmagen Granulation layer is disclosed. An encapsulant is disposed over that bi-layer tablet. The encapsulated bi-layer tablet includes an orally therapeutically effective dose of oxycodone in combination with dextromethorphan, where the weight ratio of oxycodone to dextromethorphan is 1:5. The oral dosage form does not include an opioid antagonist.
Alkylated Etiocholanolones And Use As An Anti-Diabetic, Anti-Obesity And Erythropoietic Agent
16-Alkylated and 16-alkylated-7-hydroxy 5. beta. -androstan-3-ol-17-one, and the esters and ethers thereof, are used as an anti-diabetic, anti-obesity and erythropoietic agent in mammals.
5-. beta. -androstandione is produced in high yield by contacting androstendione with a palladium catalyst and thereafter recovering the 5-. beta. -androstandione thus produced.
Crosslinked Acrylamide Polymer Compositions And Shaped Articles Therefrom
An improved ostomy seal is provided by a crosslinked composition comprising a water-soluble acrylamide polymer, a plasticizing quantity of a water-miscible polyol (containing water) that provides an elastomeric gel, and a crosslinking polyaldehyde.
Process For The Production Of Alpha-6-Deoxytetracyclines
A process for the preparation of alpha-6-deoxytetracyclines from the corresponding 6-methylenetetracyclines is described using a silica-supported heterogeneous rhodium catalyst: ##STR1## The process stereospecifically produces the alpha epimers at higher yields while using lower rhodium metal levels than prior methods.