Joseph Rainville - Uncasville CT, US Geraldine Taber - Mystic CT, US
International Classification:
C07D 487/02
US Classification:
544343000
Abstract:
The present invention relates to a new process for the preparation of substituted quinoxalines (I) by cyclization of the corresponding dianiline with 2,3 dihydroxy-1,4-dioxane. In a preferred embodiment, the invention provides a process for the preparation of compounds having the formula wherein Q is a nitrogen protecting group. Compounds of formula III and their derivatives are precursors to certain aryl fused azapolycyclic compounds which exhibit activity as agents for the treatment of neurological and psychological disorders.
Process For Preparation Of 1-(2S,3S)-2-Benzhydryl-N-(5- Tert-Butyl-2-Methoxybenzyl)Quinuclidin-3-Amine
Patricia A. Basford - Kent, GB Ronald J. Post - Mystic CT, US Julina D. Smith - Kent, GB Geraldine P. Taber - Mystic CT, US
International Classification:
C07D 453/02
US Classification:
546133
Abstract:
This invention relates to an improved process for the preparation of (2S,3S)-2-benzhydryl-N-(5-tent-butyl-2-methoxybenzyl)quinuclidin-3-amine, (hereinafter “compound of Formula I”) and its pharmaceutically acceptable salts. In particular, the invention is directed to an improved synthesis of the monohydrate citrate salt of the compound of Formula (Ia).
Stereoselective Hydrogenation Process For Preparing Cis-6-Phenyl-5-[4-(2-Pyrrolidin-1-Yl-Ethoxy)-Phenyl]-2-Methoxy-5,6,7,8-Tetrahydronaphthalene Hydrochloride
Geraldine Patricia Taber - Mystic CT, US Richard Shelton Lehner - Ledyard CT, US
International Classification:
C07D 207/06
US Classification:
548576
Abstract:
This invention provides an improved process for preparing cis-6-phenyl-5-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-2-methoxy-5,6,7,8-tetrahydronaphthalene hydrochloride which is an intermediate for the preparation of (−)-cis-6-phenyl-5-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-5,6,7,8-tetrahydronaphthalene-2-ol which is useful for the treatment of osteoporosis.
Juan Carlos Colberg - Norwich CT David Michael Pfisterer - Mystic CT Geraldine Patricia Taber - Mystic CT
Assignee:
Pfizer Inc - New York NY
International Classification:
C07C24902
US Classification:
564271
Abstract:
This invention relates to a novel improved process for preparation of N-[4-(3,4-dichlorophenyl)-3,4-dihydro-1(2H)-naphthalenylidene]methanamine from 4-(3,4-dichloro-phenyl)-3,4-dihydro-1(2H)-naphthalenone and monomethylamine.