Gerry Stephen Oxford

Author:

Gerry S. Oxford

ISBN #:

0874700450

US Patent:

20150125953, May 7, 2015

Filed:

May 6, 2013

Appl. No.:

14/398664

Inventors:

- Indianapolis IN, US
Gerry Oxford - Indianapolis IN, US
Karl R. Koehler - Indianapolis IN, US

International Classification:

C12N 5/071

US Classification:

435366

Abstract:

Disclosed herein are methods and compositions for generating cultures and isolated cell populations containing preplacodal ectoderms cells, otic placode cells, and inner ear sensory hair cells derived from pluripotent cells by modulating TGFβ, BMP, and FGF signaling pathways under defined culture conditions. Also described are methods for obtaining non-otic placodal tissues from pluripotent stem cells. Methods for identifying agents that induce or enhance differentiation and generation of hair cells are also disclosed. Methods for identifying cytoprotective agents for hair cells are also described.