Guy D Diana

US Patent:

20050288258, Dec 29, 2005

Filed:

Apr 23, 2003

Appl. No.:

10/511430

Inventors:

Guy Diana - Pottstown PA, US
Thomas Bailey - Phoenixville PA, US
Dorothy Young - Gainesville VA, US
Srinivas Chunduru - West Chester PA, US

International Classification:

A61K031/675

US Classification:

514089000, 546022000

Abstract:

Pyridine derivatives that exhibit antiviral activity are disclosed.

US Patent:

47677880, Aug 30, 1988

Filed:

Mar 29, 1982

Appl. No.:

6/362633

Inventors:

Guy D. Diana - Stephentown NY

Assignee:

Sterling Drug Inc. - New York NY

International Classification:

A61K 3119

US Classification:

514574

Abstract:

The process of, and compositions, articles and packages for, inactivating or destroying viruses with glutaric acid are disclosed.

US Patent:

51108216, May 5, 1992

Filed:

Jun 7, 1990

Appl. No.:

7/534917

Inventors:

Guy D. Diana - Stephentown NY

Assignee:

Sterling Drug Inc. - New York NY

International Classification:

C07D41310
A61K 3142

US Classification:

514364

Abstract:

Compounds of the formula ##STR1## wherein: Y is an alkylene bridge of 3-9 carbon atoms; R' is lower-alkyl or hydroxy-lower-alkyl or 1-5 carbon atoms; R. sub. 1 and R. sub. 2 are hydrogen, halogen, lower-alkyl, lower-alkoxy, nitro, lower-alkoxycarbonyl or trifluoromethyl; and R. sub. 8 is hydrogen or lower-alkyl of 1-5 carbon atoms, with the proviso that when R. sub. 8 is hydrogen R' is hydroxy-lower-alkyl, are useful as antiviral agents, particularly against picornaviruses, including numerous strains of rhinovirus.

US Patent:

42321611, Nov 4, 1980

Filed:

Oct 24, 1979

Appl. No.:

6/087880

Inventors:

Guy D. Diana - Stephentown NY
Philip M. Carabateas - Schodack NY

Assignee:

Sterling Drug Inc. - New York NY

International Classification:

C07D40104

US Classification:

546279

Abstract:

4-(Aryloxyalkyl)pyrazoles of the formula ##STR1## useful as antiviral agents, are prepared by reacting the corresponding diketones of the formula Ar-O-Alk-CH(COR')COR" with hydrazine or a substituted hydrazine H. sub. 2 NNHR. Mono- or bis-pyrazoles are similarly obtained from bis-diketones of the formula ##STR2##.

US Patent:

55146929, May 7, 1996

Filed:

May 24, 1995

Appl. No.:

8/449463

Inventors:

David J. Aldous - Glenmore PA
Thomas R. Bailey - Phoenixville PA
Guy D. Diana - Pottstown PA
Theodore J. Nitz - Pottstown PA
Michael Reuman - Audubon PA

Assignee:

Sterling Winthrop Inc. - New York NY

International Classification:

A61K 3147
C07D40104

US Classification:

514314

Abstract:

The invention discloses compounds of the formula ##STR1## wherein, Het. sub. 1 is chosen from the group consisting of substituted or unsubstituted furyl, oxazolyl, isoxazolyl, oxadiazolyl, tetrazolyl, thiadiazolyl Y is an alkylene bridge of 3 to 9 carbon atoms. Het. sub. 2 is quinolyl quinolyl substituted by R. sub. 1 and R. sub. 2 ; R. sub. 1 and R. sub. 2 are each individually chosen from hydrogen, halo, alkyl, alkenyl, amino, alkylthio, hydroxy, hydroxyalkyl, alkoxyalkyl, alkylthioalkyl, alkylsulfinyl alkyl, alkylsulfonylalkyl, alkoxy, nitro, carboxy, alkoxycarbonyl, dialkylaminoalkyl, alkylaminoalkyl, aminoalkyl, difluoromethyl, trifluoromethyl or cyano; R. sub. 3 is alkyltetrazolyl, or substituted or unsubstituted heterocyclyl chosen from benzoxazolyl, benzathiazolyl, thiadiazolyl, imidazolyl, dihydroimidazolyl, oxazolyl, thiazolyl, oxadiazolyl, pyrazolyl, isoxazolyl, isothiazolyl, furyl, triazolyl, tetrazolyl, thiophenyl the N-oxide thereof or a pharmaceutically acceptable acid addition salt thereof are effective antipicornaviral agents.

US Patent:

56188218, Apr 8, 1997

Filed:

May 26, 1995

Appl. No.:

8/451692

Inventors:

David J. Aldous - Glenmore PA
Thomas R. Bailey - Phoenixville PA
Guy D. Diana - Pottstown PA
Theodore J. Nitz - Pottstown PA

Assignee:

Sanofi, S.A. - Paris Cedex

International Classification:

A61K 3144
A61K 31505
C07D21316
C07D23926

US Classification:

514277

Abstract:

Compounds of the formula ##STR1## wherein Q is chosen from the group consisting of pyridyl, pyrazyl, pyrimidyl, quinolyl, indolyl and 7-azaindolyl or any of these substituted with one or two substituents; Y is an alkylene bridge of 3-9 carbon atoms; R. sub. 1 and R. sub. 2 are each independently chosen from hydrogen, halo, alkyl, alkenyl, amino, alkylthio, hydroxy, hydroxyalkyl, alkoxyalkyl, alkylthioalkyl, alkylsulfinylalkyl, alkylsulfonylalkyl, alkoxy, nitro, carboxy, alkoxycarbonyl, dialkylaminoalkyl, alkylaminoalkyl, aminoalkyl, difluoromethyl, trifluoromethyl or cyano; R. sub. 3 is alkoxycarbonyl, alkyltetrazolyl, substituted or unsubstituted phenyl or heterocyclyl, the N-oxide thereof, or a pharmaceutically acceptable acid addition salt thereof is an effective antipicornaviral agent.

US Patent:

58309055, Nov 3, 1998

Filed:

Mar 29, 1996

Appl. No.:

8/625718

Inventors:

Guy D. Diana - Pottstown PA
Thomas R. Bailey - Phoenixville PA
Theodore J. Nitz - Pottstown PA

Assignee:

Viropharma Incorporated - Malvern PA

International Classification:

A61K 31445
C07D40106

US Classification:

514322

Abstract:

Derivatives of piperidine are useful in prophylaxis and treatment of hepatitis C virus infections.

US Patent:

41196686, Oct 10, 1978

Filed:

Sep 15, 1977

Appl. No.:

5/833485

Inventors:

Guy D. Diana - Stephentown NY
Royal A. Cutler - Sand Lake NY

Assignee:

Sterling Drug Inc. - New York NY

International Classification:

C07C 8730
A61K 3114

US Classification:

2605676P

Abstract:

N,N'-Bridged-bis[(O and/or N-substituted)-2-alkyl-2-hydroxyethylamines] of the formula ##STR1## are prepared by condensing an epoxide of the formula ##STR2## and a diamine of the formula R'NH-X-NHR'. The products and dicarbanilates, acid-addition salts, N,N'-dioxides and N,N'-diammonium quaternary salts derived therefrom have antibacterial activity in vitro and are useful as antibacterial agents.