Harley Russell Liker

US Patent:

8178137, May 15, 2012

Filed:

Mar 15, 2007

Appl. No.:

12/282800

Inventors:

Harley Liker - Los Angeles CA, US

Assignee:

Pom Wonderful, LLC - Los Angeles CA

International Classification:

A61K 36/00

US Classification:

424769, 424777, 424424, 424725

Abstract:

Pomegranate juice consumption by a patient may be used to treat prostate cancer. Prior to the present invention, it has been observed that various pomegranate compositions have cancer chemopreventive properties on various in vitro treatment of human prostate cancer cell lines and in vivo treatment of human prostate cancer cell lines xenografted in athymic nude mice. Until the discovery of the present invention, it was not known if there is an efficacy for treating prostate cancer in human patient by any route of administration. The present invention provides a method of treating a subject with prostate cancer a composition comprising a therapeutically effective amount of an extract from pomegranate fruit. The extract of pomegranate may be a juice extract of pomegranate, an extract from inner or outer peel of pomegranate, or mixture thereof. Pomegranate juice may be used to treat subjects with rising serum PSA after prostate surgery or radiotherapy.

US Patent:

8372454, Feb 12, 2013

Filed:

Mar 16, 2010

Appl. No.:

12/724661

Inventors:

Michael Aviram - Kiriat-Haim, IL
Harley R. Liker - Beverly Hills CA, US

Assignee:

Pom Wonderful LLC - Los Angeles CA

International Classification:

A61K 36/00

US Classification:

424769, 424725, 424777

Abstract:

Various processes for producing an extract containing phytochemicals from pomegranates are disclosed. The processes generally comprise providing pomegranate solids, such as the pericarp, inner membrane and seeds; creating a mixture comprising the pomegranate solids in an aqueous solution; adding enzymes to the mixture in an amount sufficient to at least partially degrade the pomegranate solids; heating the mixture to a temperature that permits the maximum rate of catalysis of the enzyme; maintaining the temperature of the heated mixture for a time sufficient to allow at least partial degradation of the pomegranate solids; and removing residual insoluble solid materials from the mixture. Compositions containing the extract may be used as a food product, beverage, pharmaceutical preparations, nutritional supplements, vitamin supplements, food additives, and food supplements. The compositions may also be used for preventing or ameliorating disease conditions by administering an effective amount of the composition to a subject in need thereof.

US Patent:

8597699, Dec 3, 2013

Filed:

May 8, 2012

Appl. No.:

13/466849

Inventors:

Harley Liker - Los Angeles CA, US

Assignee:

POM Wonderful, LLC - LA CA

International Classification:

A61K 36/00

US Classification:

424769, 424725, 424777

Abstract:

A method of increasing a prostate specific antigen (PSA) doubling time in treating a patient. A subject with rising serum PSA is selected. A composition is administered to the subject comprising a therapeutically effective amount of a pomegranate extract comprising a higher content of high molecular weight polyphenol compared to pomegranate juice from arils. The therapeutically effective amount increases a prostate specific antigen doubting time. The pomegranate extract is formed from an insoluble byproduct component obtained by placing pomegranate solids in an aqueous solution, heating the aqueous solution to between about 60 F. to about 210 F. , adding at least one enzyme to the aqueous solution, and removing residual insoluble solid materials from the aqueous solution.

US Patent:

8609152, Dec 17, 2013

Filed:

Mar 23, 2010

Appl. No.:

12/730119

Inventors:

Mohammad Madjid - Houston TX, US
Harley R. Liker - Beverly Hills CA, US

International Classification:

A61K 36/00

US Classification:

424725

Abstract:

Methods and compositions for treating at least one symptom of a viral infection, said method of treatment comprising administering to a subject with a least one symptom of a viral infection an effective dosage unit of a composition comprising pomegranate extract. The compositions comprise pomegranate extract comprising polyphenols. The composition is produced by a process comprising providing one or more pomegranate solids selected from the group consisting of a pericarp, inner membrane and seeds, creating a mixture comprising said one or more pomegranate solids in an aqueous solution, heating said mixture to a temperature that permits enzyme catalysis of said pomegranate solids, and removing residual insoluble solid materials from said mixture to provide said pomegranate extract. Compositions containing the extract may be used as a food product, beverage, pharmaceutical preparations, nutritional supplements, vitamin supplements, food additives, and food supplements.

US Patent:

20060269629, Nov 30, 2006

Filed:

May 24, 2005

Appl. No.:

11/137248

Inventors:

Byron Bates - Bakersfield CA, US
Erich Fritz - Westlake Village CA, US
Yair Henig - Beverly Hills CA, US
Harley Liker - Beverly Hills CA, US

Assignee:

PomWonderful LLC - Los Angeles CA

International Classification:

A61K 36/185

US Classification:

424769000, 424777000

Abstract:

Processes for producing an extract containing phytochemicals from pomegranates are disclosed. The processes generally comprise providing pomegranate solids, such as the pericarp, inner membrane and seeds; creating a mixture comprising the pomegranate solids in an aqueous solution; adding enzymes to the mixture in an amount sufficient to at least partially degrade the pomegranate solids; heating the mixture to a temperature that permits the maximum rate of catalysis of the enzyme; maintaining the temperature of the heated mixture for a time sufficient to allow at least partial degradation of the pomegranate solids; and removing residual insoluble solid materials from the mixture. Compositions containing the extract may be used as a food product, beverage, pharmaceutical preparations, nutritional supplements, vitamin supplements, food additives, and food supplements. The composition may also be used for preventing or ameliorating disease conditions by administering an effective amount of the composition to a subject in need thereof.

US Patent:

20100009019, Jan 14, 2010

Filed:

Sep 22, 2009

Appl. No.:

12/564878

Inventors:

Byron Bates - Bakerfield CA, US
Erich A. Fritz - Westlake Village CA, US
Yair Steve Henig - Beverly Hills CA, US
Harley R. Liker - Beverly Hills CA, US

Assignee:

POM WONDERFUL LLC - Los Angeles CA

International Classification:

A61K 36/185
C12P 1/00
A61P 35/00
A61P 13/08

US Classification:

424776, 435 41

Abstract:

Processes for producing an extract containing phytochemicals from pomegranates are disclosed. The processes generally comprise providing pomegranate solids, such as the pericarp, inner membrane and seeds; creating a mixture comprising the pomegranate solids in an aqueous solution; adding enzymes to the mixture in an amount sufficient to at least partially degrade the pomegranate solids; heating the mixture to a temperature that permits the maximum rate of catalysis of the enzyme; maintaining the temperature of the heated mixture for a time sufficient to allow at least partial degradation of the pomegranate solids; and removing residual insoluble solid materials from the mixture. Compositions containing the extract may be used as a food product, beverage, pharmaceutical preparations, nutritional supplements, vitamin supplements, food additives, and food supplements. The compositions may also be used for preventing or ameliorating disease conditions by administering an effective amount of the composition to a subject in need thereof.

US Patent:

20120269887, Oct 25, 2012

Filed:

Nov 17, 2011

Appl. No.:

13/299356

Inventors:

Mark Dreher - , US
Harley Liker - Los Angeles CA, US
Yair Steve Henig - Beverly Hills CA, US

International Classification:

A61K 31/7048
A61K 9/48
A61K 9/24
A61K 9/00

US Classification:

424451, 424400, 424472, 514 23

Abstract:

A pharmaceutical composition with an active pharmaceutical ingredient including a pomegranate fruit polyphenol extract. The pomegranate fruit polyphenol extract includes at least about 3% combined punicalagin A and punicalagin B by weight, less than about 5% ellagic acid and their derivatives by weight, and less than about 1% anthocyanins by weight.

US Patent:

20140056930, Feb 27, 2014

Filed:

Oct 30, 2013

Appl. No.:

14/067754

Inventors:

Harley LIKER - Los Angeles CA, US

Assignee:

Pom Wonderful, LLC - Los Angeles CA

International Classification:

A61K 39/00

US Classification:

4241841

Abstract:

A method of increasing a prostate specific antigen (PSA) doubling time in treating a patient. A subject with rising serum PSA is selected. A composition is administered to the subject comprising a therapeutically effective amount of a pomegranate extract comprising a higher content of high molecular weight polyphenol compared to pomegranate juice from arils. The therapeutically effective amount increases a prostate specific antigen doubling time. The pomegranate extract is formed from an insoluble byproduct component obtained by placing pomegranate solids in an aqueous solution, heating the aqueous solution to between about 60 F. to about 210 F., adding at least one enzyme to the aqueous solution, and removing residual insoluble solid materials from the aqueous solution.