Harold Zappe from 505 Orvil Smith Rd, Harvest, AL 35749, age 69, Phone: 2567213946

Von Willebrand Factor- And Factor Viii-Polymer Conjugates Having A Releasable Linkage
view source
US Patent:

8349800, Jan 8, 2013
Filed:

Feb 10, 2012
Appl. No.:

13/371275
Inventors:

Mary J. Bossard - Madison AL, US
Gayle Stephenson - Decatur AL, US
Zhihao Fang - Madison AL, US
Harold Zappe - Harvest AL, US
Stacy Mitchell - Madison AL, US
Ping Zhang - Madison AL, US
Friedrich Scheiflinger - Vienna, AT
Peter Turecek - Klosterneuburg, AT
Juergen Siekmann - Vienna, AT
Katalin Varadi - Vienna, AT
Herbert Gritsch - Vienna, AT
Assignee:

Nektar Therapeutics - San Francisco CA
Baxter International Inc. - Deerfield IL
Baxter Healthcare S.A. - Wallisellen
International Classification:

C07K 14/755
C07K 14/745
C07K 17/08
US Classification:

514 141, 514 137, 530380, 530383
Abstract:

The present invention provides von Willebrand Factor-polymer conjugates and Factor VIII-polymer conjugates, each having a releasable linkage. Methods of making conjugates, methods for administering conjugates, are also provided.

Polymer Conjugates Of Nesiritide Peptides
view source
US Patent:

8449872, May 28, 2013
Filed:

Sep 17, 2009
Appl. No.:

13/119215
Inventors:

Harold Zappe - Harvest AL, US
Mary J. Bossard - Madison AL, US
Assignee:

Nektar Therapeutics - San Francisco CA
International Classification:

A61K 47/48
A61K 38/12
C07K 14/00
C07K 1/107
C08G 65/48
US Classification:

424 7817, 530317, 525 541, 514 211
Abstract:

The invention provides peptides that are chemically modified by covalent attachment of a water-soluble oligomer. A conjugate of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from the characteristics of peptide not attached to the water-soluble oligomer.

Von Willebrand Factor-And Factor Viii-Polymer Conjugates Having A Releasable Linkage
view source
US Patent:

20080234193, Sep 25, 2008
Filed:

Dec 27, 2007
Appl. No.:

12/006059
Inventors:

Mary J. Bossard - Madison AL, US
Gayle Stephenson - Decatur AL, US
Zhihao Fang - Madison AL, US
Harold Zappe - Harvest AL, US
Stacy Mitchell - Madison AL, US
Ping Zhang - Madison AL, US
Friedrich Scheiflinger - Vienna, AT
Peter Turecek - Klosterneuburg, AT
Juergen Siekmann - Vienna, AT
Katalin Varadi - Vienna, AT
Herbert Gritsch - Vienna, AT
Assignee:

Nektar Therapeutics AL, Corporation - Huntsville AL
Baxter International Inc. - Deerfield IL
Baxter Healthcare SA - Wallisellen
International Classification:

A61K 47/48
C07K 14/00
A61K 38/16
US Classification:

514 12, 527200
Abstract:

The present invention provides von Willebrand Factor-polymer conjugates and Factor VIII-polymer conjugates, each having a releasable linkage. Methods of making conjugates, methods for administering conjugates, are also provided.

Methods For Determining Active Ingredients In Pro-Drug Peg Protein Conjugates With Releasable Peg Reagents (In Vitro De-Pegylation)
view source
US Patent:

20100112607, May 6, 2010
Filed:

Oct 20, 2009
Appl. No.:

12/582497
Inventors:

Katalin Varadi - Vienna, AT
Gerald Schrenk - Vienna, AT
Hanspeter Rottensteiner - Vienna, AT
Peter Turecek - Klosterneuburg, AT
Alfred Weber - Vienna, AT
Heinz Anderle - Klosterneuburg, AT
Sean M. Culbertson - Gurley AL, US
Zhihao Fang - Madison AL, US
Harold Zappe - Harvest AL, US
Ping Zhang - Madison AL, US
Mary J. Bossard - Madison AL, US
Assignee:

BAXTER INTERNATIONAL INC. - Deerfield IL
BAXTER HEALTHCARE S.A. - Glattpark ( Opfikon)
NEKTAR THERAPEUTICS - San Carlos CA
International Classification:

G01N 33/53
C07K 14/00
US Classification:

435 792, 530350, 436 86
Abstract:

The invention relates to the development of in vitro assay systems that force the release of a water-soluble polymer, such as polyethylene glycol (PEG) and polysialic acid (PSA), from proteins modified with a reversibly-linked water-soluble polymer. The invention includes methods for analyzing the release of the water-soluble polymer and measuring regained protein activity. The invention further includes methods appropriate for the quality control of proteins modified with releasable water-soluble polymers, including polymers like PEG and PSA.

Conjugates Of A Cholinesterase Moiety And A Polymer
view source
US Patent:

20110135623, Jun 9, 2011
Filed:

May 15, 2009
Appl. No.:

12/991402
Inventors:

Mary J. Bossard - Madison AL, US
Harold Zappe - Harvest AL, US
Seoju Lee - Madison AL, US
Lal Ajitha Ratnapala Fernando - Hillsborough NJ, US
Assignee:

NEKTAR THERAPEUTICS - SAN CARLOS CA
International Classification:

A61K 38/46
C12N 9/96
A61P 25/00
US Classification:

424 946, 435188
Abstract:

Conjugates of a cholinesterase moiety and one or more nonpeptidic, water soluble polymers are provided. Typically, the nonpeptidic, water soluble polymer is poly(ethylene glycol) or a derivative thereof. Also provided, among other things, are compositions comprising conjugates, methods of making conjugates, and methods of administering compositions to a patient.

Polymer Conjugates Of Therapeutic Peptides
view source
US Patent:

20110166063, Jul 7, 2011
Filed:

Sep 17, 2009
Appl. No.:

13/119297
Inventors:

Mary J. Bossard - Madison AL, US
Steven O. Roczniak - Greensboro NC, US
Harold Zappe - Harvest AL, US
Yujun Wang - Madison AL, US
Ping Zhang - Madison AL, US
Dawei Sheng - Madison AL, US
C. Simone Jude-Fishburn - Redwood City CA, US
Elizabeth Louise Minamitani - Lacey's Spring AL, US
Xiaofeng Liu - Union City CA, US
Haim Moskowitz - San Diego CA, US
Dennis G. Fry - Huntsville AL, US
Cherie F. Ali - Burlingame CA, US
Christine Taylor Brew - Pacifica CA, US
Assignee:

Nektar Therapeutics - San Francisco CA
International Classification:

A61K 38/28
A61K 38/16
A61K 38/08
A61K 38/06
A61K 38/07
A61K 38/10
C07K 5/08
C07K 7/06
C07K 7/08
C07K 14/00
A61P 3/10
US Classification:

514 59, 514 213, 514 212, 514 217, 514 216, 514 219, 514 218, 514 215, 530303, 530331, 530330, 530329, 530328, 530327, 530326, 530324, 530350
Abstract:

The invention provides peptides that are chemically modified by covalent attachment of a water-soluble oligomer. A conjugate of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from the characteristics of the peptide not attached to the water-soluble oligomer.

Polymer Conjugates Of Kiss1 Peptides
view source
US Patent:

20110171160, Jul 14, 2011
Filed:

Sep 17, 2009
Appl. No.:

13/119211
Inventors:

Elizabeth Louise Minamitani - Lacey's Spring AL, US
Harold Zappe - Harvest AL, US
Mary J. Bossard - Madison AL, US
Steven O. Roczniak - Greensboro NC, US
Xiaofeng Liu - Union City CA, US
Assignee:

Nektar Therapeutics - San Francisco CA
International Classification:

A61K 47/48
C08G 65/48
A61P 35/04
US Classification:

424 7817, 525 541
Abstract:

The invention provides peptides that are chemically modified by covalent attachment of a water soluble oligomer. A conjugate of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from the characteristics of the peptide not attached to the water soluble oligomer.

Polymer Conjugates Of Thymosin Alpha 1 Peptides
view source
US Patent:

20110171162, Jul 14, 2011
Filed:

Sep 17, 2009
Appl. No.:

13/119218
Inventors:

Harold Zappe - Harvest AL, US
Mary J. Bossard - Madison AL, US
Assignee:

NEKTAR THERAPEUTICS - San Francisco CA
International Classification:

A61K 47/48
C08G 65/48
A61P 31/12
US Classification:

424 7817, 525 541
Abstract:

The invention provides peptides that are chemically modified by covalent attachment of a water soluble oligomer. A conjugate of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from the characteristics of the peptide not attached to the water soluble oligomer.